ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00373.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYSeven cases of adrenocortical hyperfunction associated with ACTH secreting carcinoid tumours of lung are reported. The clinical manifestations, laboratory investigations and treatment are compared with twenty‐one similar cases already recorded. The clinical picture of this disorder shows features of both pituitary dependent Cushing's syndrome and of the ectopic ACTH syndrome associated with carcinoma of lung. The problems of accurate diagnosis are described. The effects of treatment, both surgical and medical, of the adrenocortical hyperfunction are described and the problems of identifying and removing the carcinoid tumour are discusse

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00374.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYBioactive and immunoreactive corticotrophin (ACTH) concentrations in seventeen tumours from patients with the ectopic ACTH syndrome were compared with those in fourteen ‘control’tumours from patients without the syndrome. Each of the ‘control’tumours showed ACTH activity greater than in non‐tumorous tissue and the range of concentrations overlapped with the ‘ectopic ACTH’group. The presence of significant ACTH activity in every tumour studied suggests that hormone production may be a common feature of neoplasia in the absence of clinically obvious sequelae of excess circulating hormone. Tumours associated with the ectopic ACTH syndrome showed a wide range of ACTH activities: bronchial carcinoid tumours generally contained higher levels than oat cell carcinomas of the bronchus and more C‐ than N‐terminal ACTH activity. In twenty‐four patients with the clinical syndrome the plasma ACTH levels were not clearly related to tumour type; the levels ranged between 100 and 10,000 pg/ml, showed an abnormal nyctohemeral rhythm, and fell following successful re

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00375.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThirty‐three patients with Addison's disease have been investigated with particular reference to thyroid function, thyroid antibody status and serum TSH measurements.Of twenty‐seven patients with idopathic or probably idiopathic Addison's disease, fifteen had antibodies against adrenal tissue and thirteen had thyroid microsomal antibodies. No patient with tuberculous Addison's disease had evidence of thyroid disease or of either adrenal or thyroid antibodies.The response to injected TSH was usually impaired in patients who had antithyroid antibodies in their serum. This test was cumbersome but appeared to indicate the reserve capacity of the thyroid.Serum TSH levels were raised in ten of the thirteen patients who had thyroid antibodies, including six whose protein bound‐iodine levels were below 4.0μ/100 ml. Three antibody negative subjects also had an elevated TSH level.The most sensitive indication of subclinical thyroid disease appeared to be a positive thyroid antibody test. Estimation of the serum TSH level appeared to correlate with more advanced disease and with the earliest evidence of failure of thyroid function.It is suggested that serum TSH measurements are clinically helpful in patients with positive thyroid antibody testes and in patients with low or low normal proteinbound iodine

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00376.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYPlasma and urine calcium and phosphate were determined in nine patients before and after oophorectomy and in eleven patients before and after simple hysterectomy. Oophorectomy was followed by a significant rise in the mean plasma and fasting urine calcium, and a mean rise of 37 mg in the 24 hr calcium which, however, was not significant. Hysterectomy alone caused no significant change in plasma or urine calcium. In both groups only small changes were observed in plasma and urine phosphate and these did not reach the level of significance. The mean urine hydroxyproline/creatinine ratio rose significantly in six patients after oophorectomy but did not change after hysterectomy. It is suggested the rise in plasma and urine calcium following oophorectomy is due to increased bone resorption which does not occur after simple hysterectomy.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00377.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYFollowing the rapid intravenous injection of corticosteroids (cortisol, prednisolone, betamethasone and betamethasone‐17‐valerate), the blood levels of each were estimated and the results analysed in a two‐compartment open model. The kinetic analysis revealed differences in distribution and elimination which could have important therapeuticimplications. A theory is presented for the marked differences seen, and the therapeutic importance of these is disc

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00378.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThe excretion of preganediola and the 6‐oxygenated metabolites of progesterone was measured during the last 12 weeks of pregnancy in fifty‐five women. There was no significant change in pregnanediol excretion during the last 10 weeks of pregnancy but during this time there was a significant increase in the excretion of the 6‐oxygenated metabolites. There was a significant correlation between the excretion of these latter metabolites and both fetal and placental weights at term. It is suggested that the 6‐oxygenated metabolites may be arising from the fetal 6‐hydroxylation of progesterone. In some patients with severe toxaemia pregnanediol excretion was low although excretion of 6‐oxygenated metabolites was within the n

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00379.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYTen pregnant women with a history of past or present hyperthyroidism were investigated. Three of these patients had evidence of LATS activity in their serum. Two of these had infants who had LATS activity in their cord blood; a pair of twins, and a singleton. These three infants developed neonatal thyrotoxicosis. Serial samples of blood from these infants indicated a half life LATS disappearance of 4.1, 6.7 and 7.6 days respectively.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00380.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThe effect of methandrostenolone on plasma growth hormone levels was studied in twenty‐two apparently healthy prepubertal children (nineteen males and three females) with idiopathic growth retardation, following insulin hypoglycaemia (eight children) or arginine infusion (fourteen children). The tests were performed before and after 5 days or 34 months of peroral administration of methandrostenolone (0.1 54.33 or 0.03‐0.05 mg/kg/day, respective

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00381.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThe first results of serum neurphysine determinations by radioimmunoassay in normal man and in several pathological states are reported.Under baseline conditions neurophysine levels are higher in women than in men. In women, moreover, they are elevated during pregnancy and decline rapidly postpartum. During labour and suckling there is no significant change in maternal neurophysine. Neonates, and particularly premature infants, have higher serum neurophysine concentrations than adults.Under certain physiological conditions (water load, dehydration) there is a concordance between serum neurophysine and antidiuresis, whereas these two factors are discordant in states marked by endocrine alterations (anterior pituitary insufficiency, adrenal insufficiency, oestrogen ingestion). A dissociation between neurophysine levels and antidiuresis is also observed during nicotine stimulation by cigarette inhalation. The significance of this dissociation is discussed.Renal insufficiency whether or not treated by dialysis is accompanied by constatly elevated neurophysine levels, while obesity is sometimes although not always associated with a marked increase in neuropysine. A rise in serum neurophysine is seen only rarely in anterior pituitary insufficiency.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00382.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY