摘要:

SUMMARYThree patients with active acromegaly and salivary gland enlargement are described. Detailed studies of flow rate, the biochemistry of the saliva from both the parotid and submandibular salivary glands, sialography and isotope scanning of the glands showed no significant abnormality in function. The literature is reviewed and it would appear that enlargement of the submandibular salivary glands in acromegaly is a relatively common clinical finding although it is not widely known.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03290.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYA radioimmunoassay for the determination of testosterone in human plasma is described. After extraction from plasma, testosterone is separated by paper chromatography. The radioimmunoassay is performed using an antiserum to testosterone‐3‐oxime‐rabbit serum albumin and a saturated solution of ammonium sulphate is used for separation. The reliability criteria of the method in terms of precision, accuracy, sensitivity and specificity have been evaluated.The mean level of testosterone in plasma samples from nineteen normal men (age range 16–73 years) is 527±226 (±SD) ng/100 ml. In ten normal ambulatory females (in the second phase of the cycle) aged 19–35 years the mean plasma testosterone is 27±8±10±6 (±SD) ng/100 ml. In twenty‐four impotent men (aged 18–50) the testosterone level is 431±191 (mean±SD) ng/100 ml. These values are not significantly different from normal subjects.Lastly, the testosterone levels found in a few cases of male hypo

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03291.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe duration of action of 100μg of the synthetic gonadotrophin releasing hormone, the decapeptide LH/FSH‐RH, was compared in three subjects after intravenous, intramuscular and subcutaneous administration, given in random order at 7–10 day intervals. The levels of serum LH and FSH were followed over 9 hr. Each route of administration was equally effective in promoting LH and FSH release, and the magnitude of the responses and their time course were the same in each case. Two of these subjects then received 2 mg of the pure material dissolved in 0±5 or 1 ml of 0±9% NaCl by intranasal application. Although definite LH and FSH responses were seen, this route was less effective in promoting gonadotrophin release despite the higher dose used. In three further subjects blood sampling was carried out at 10 min intervals for 4 hr, following i.v., i.m. or s.c. injection of LH/FSH‐RH; pulsatile release of LH and FSH was observed in each subject but the fluctuations in LH and FSH were asynchronous. The therapeutic implications of subcutaneous and intranasal administration of the material are d

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03292.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe release of gonadotrophin following the injection of synthetic LH‐RH (Hoechst) was studied in various physiological and experimental circumstances.In the male, 25μg of LH‐RH led to simultaneous release of FSH and LH prior to and during puberty. In adults, on the other hand, the same dose led only to an increase in LH while FSH levels remained unchanged. At higher doses there was FSH release and an increase in LH proportional to the amount of LH‐RH injected. When FSH was released the increase was clearly less than that of LH and often occurred considerably later.In the female, 25μg of LH‐RH led to a clear‐cut release of FSH and a small release of LH prior to puberty. After the onset of puberty the degree of response was inverted: the increase in LH was greater than that of FSH. In normally menstruating women the FSH and LH response was greater during the luteal phase than during the preovulatory phase. Treatment with non‐sequential hormonal contraceptives blocked FSH and LH release normally produced by the injection of 50μg of LH‐RH. There was no effect when a dose of 100μg was injected.In post‐menopausal women, only LH rose following the administration of 25μg of LH‐RH. After 5 days of treatment with 200μg ethinyl oestradiol the same dose of LH‐RH led to simultaneous release of LH and of FSH.From the above studies it can be concluded that the secretory response of the gonadotrophins to LH‐RH is influenced by the endocrine equilibrium and more particularly by the interaction of the gonadal steroids which can alter the synthesis and/or the release of t

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03293.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYPlasma aldosterone, plasma cortisol and plasma renin activity were determined at short time intervals in three supine patients suffering from primary aldosteronism. The patients were studied both under normal conditions and during suppression of ACTH secretion by dexamethasone. Though abnormally high levels were found, aldosterone was secreted episodically in each patient while plasma renin activity was uniformly undetectable. In each patient the secretory episodes of aldosterone were paralleled by those of cortisol indicating that physiological variations in ACTH secretion markedly altered the secretion of aldosterone. The assumption that ACTH played an important role in the regulation of aldosterone secretion in primary aldosteronism was strengthened by the observation that, contrary to normal controls, dexamethasone produced a significant decrease in plasma aldosterone concentrations and that during suppression of ACTH secretion no secretory episodes of aldosterone were observed.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03294.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYPatients with endemic goitre in an iodine deficient area in the Territory of Papua and New Guinea (TPNG) have very little clinical evidence of hypothyroidism although serum thyroxine (T4) levels are usually very subnormal. The activities of T4‐binding proteins in both goitrous and non‐goitrous iodine deficient TPNG subjects were therefore investigated but no overall deficiencies were found to account for the low T4levels. The mean serum T4‐binding pre‐albumin (TBPA) level (169μg/100 ml as T4‐binding capacity) was less than the level seen in Australian subjects (187μg/100 ml); however, this decrease was counteracted by the increase in T4‐binding globulin (TBG) level (27±3μg) in iodine‐deficient TPNG compared with 19±9μg in Australia.Measurements of TBG and TBPA levels were also made during pregnancy in TPNG subjects, and found to increase to the same extent as in pregnancy in Australian subjects. This suggests that the pathogenesis of endemic cretinism (in TPNG) is dependent on some factor other than TBG deficien

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03295.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYE‐rosettes (T‐lymphocytes) have been demonstrated to be increased in the peripheral blood of patients with untreated Graves’disease and decreased when these patients go into remission induced by antithyroid drugs. In patients similarly treated but not in remission, a high percentage of E‐rosettes persisted. The degree of suppression by T3of the thyroidal131I uptake correlated well with the percentage of E‐rosettes. We suggest that E‐rosette counts may prove to be a useful test for detecting remissions in thyrotoxic patients treated with antith

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03296.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe effective thyroxine ratio (ETR), a single test of thyroid function which has a highly significant linear correlation with serum free thyroxine (T4) concentration, was assessed for its effectiveness in distinguishing the euthyroid state in subjects with abnormalities of T4‐binding proteins.In patients with low activity of T4‐binding proteins, the diagnostic accuracy of the ETR (80±5%) is superior to that of the free T4index (62±5%) and free T4concentration (67%). In patients with elevated T4‐binding proteins the diagnostic accuracy of ETR was even higher at 93±5% and again better than the free T4index (83%) and the free T4concentrati

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03297.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1974.tb03298.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY