摘要:

Bromocriptine (Parlodel®) was given for 2 years to 17 parkinsonian patients showing inadequate response to treatment over a mean of 7 years with levodopa combined with a decarboxylase inhibitor. 11 of the patients had developed dyskinesia and 13 the on-off phenomenon during levodopa therapy. When the dose of bromocriptine reached 30 mg daily, after 4 weeks’ treatment, a highly significant improvement (p < 0.001) was observed in the following six variables: bradykinesia, rigidity, tremor, feeding, dressing and speech. These improvements have now been maintained for 2 years. The on-off phenomenon disappeared in 9 out of 13 patients. Side effects were mild and transient. Involuntary movements existing prior to bromocriptine administration were improved by reducing the dose of levodopa. The mean daily dose – after progressive and individual adjustment – was 46 mg bromocriptine combined with 435 mg levodopa plus decarboxylase inh

ISSN:0014-3022    

DOI:10.1159/000115484

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Results of treatment with L-dopa and/or physostigmine of patients with severe head injuries were examined and discussed. This treatment given to patients still unconscious a long period after trauma resulted in clinical improvement in 29 of the 45 trials (64%). Results were poor in patients with a low motor score and no paradoxical response on the caloric oculogram. In nearly all patients motor activity increased, but did not always result in clinical improvement. The results were explained by the presence of functional, reversible dysfunctions present in the majority of patients in the course of recovery.

ISSN:0014-3022    

DOI:10.1159/000115485

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

31 children aged between 6 weeks and 15 years, who had suffered a stroke, were investigated by computer tomography (CT). 8 patients had suffered transient ischemic attacks (TIA), 17 had completed ischemic strokes and 6 had hemorrhagic strokes. The mean interval between the stroke and the first CT investigation was 5 days. In the group of 8 patients with transient ischemic attacks, 1 patient had a small infarct, 1 had atrophy and 2 exhibited A-V malformations. In the group of 17 patients with completed ischemic strokes, 14 showed an infarct, 5 had atrophy and in 1 an angioma was found. All 6 hematomas were detected by CT. In follow-up studies, 11 of 17 patients with ischemic stroke showed atrophy.

ISSN:0014-3022    

DOI:10.1159/000115486

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

A case of acute necrotic myopathy due to epsilon-aminocaproic acid (EACA) is described and compared with similar cases in the literature. This myopathy has only been noted after prolonged administration of the drug. The pathogenesis of this necrotic myopathy remains unclear, but our findings did not support a muscular vasculitis or an autoimmune reaction. Systematic preventive measures in patients with prolonged EACA therapy are proposed.

ISSN:0014-3022    

DOI:10.1159/000115487

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Tapetoretinal degeneration in 3 members of a family is documented with fundus photographs and fluorescein angiograms. Computer tomograms showed intracranial symmetrical calcifications of the central nervous system in 2 patients. Laboratory examinations also indicated a disturbance in calcium metabolism. An autosomal dominant mode of inheritance is probably present.

ISSN:0014-3022    

DOI:10.1159/000115488

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

2 patients with breast cancer developed progressive brachial plexopathy. The unusual electromyographic finding in both patients was conduction block (neuropraxia) along the medial cord of the brachial plexus. The plexus was explored in 1 patient. Constrictive connective tissue or another source of nerve entrapment was not identified. The exact cause of the conduction block remains unclear; its presence neither indicates a good prognosis nor an indication for surgical exploration.

ISSN:0014-3022    

DOI:10.1159/000115489

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Blink reflexes, elicited by flashes of light, tone bursts and electrical stimuli, as well as checkerboard reversal visual-evoked potentials and brain stem auditory evoked potentials were investigated in 55 patients with different degrees of diagnostic probability of multiple sclerosis. It was demonstrated that electrically and acoustically elicited blink reflexes are simple but rather sensitive methods of indicating brain stem lesions. They should be used complementarily with brain stem auditory evoked potentials. Flash-elicited blink reflexes, although sensitive, are thought to be of minor importance, since they give only restricted localizing information.

ISSN:0014-3022    

DOI:10.1159/000115490

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Cervical and cortical somatosensory evoked potentials (SEPs) were recorded in 45 normal subjects. Absolute peak latencies and latency differences between the components P7, N9, N11, N13, PI7 and N20 were measured. Subjects aged 40–60 years had significantly longer latencies of Nl 3 and N20 than subjects aged 15–39 years. Moreover, statistical analysis revealed a significant prolongation of N9-N13, N11-N13 and N13-N20 transit times in older subjects. Possible connections with known morphological age-related findings are discus

ISSN:0014-3022    

DOI:10.1159/000115491

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

A case of ‘palpatory’ apraxia is reported. The apraxia was characterized by clumsiness of the left hand in the manipulation of objects with preservation of power and finger motility in visual imitation. From the analysis of the patient’s behavior and associated sensory findings, a defect of a higher-order sensory system was speculated as a basis of clums

ISSN:0014-3022    

DOI:10.1159/000115492

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

IgA, IgG and IgM concentrations were determined in sera and nasal washings from 20 patients with epilepsy on single-drug treatment with carbamazepine, in 20 patients on single-drug treatment with phenobarbital and in 26 healthy subjects. There were no significant differences in immunoglobulin concentrations between the groups of patients and the controls. Symptoms of respiratory tract disease were recorded daily during 6 months both in patients and in controls. The mean number of days with symptoms from the respiratory tract was 38.5, 36.6 and 27.9 in the patients on carbamazepine, phenobarbital and the controls, respectively. The differences were not statistically significant. The individuals with the lowest immunoglobulin concentrations did not have more frequent symptoms of respiratory disease than those with higher immunoglobulin concentrations.

ISSN:0014-3022    

DOI:10.1159/000115493

出版商:S. Karger AG    

年代:1982

数据来源: Karger