ISSN:0014-3022    

DOI:10.1159/000203032

出版商:S. Karger AG    

年代:1914

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000119490

出版商:S. Karger AG    

年代:1995

数据来源: Karger

摘要:

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the basic pathophysiology has expanded, rational approaches to therapy have evolved. The frequent presence of arterial occlusion suggested that thrombolytic therapy might be a viable approach. Both clot-specific and nonspecific thrombolytic agents are currently being evaluated in clinical trials. Focal brain ischemia induces a variety of cellular consequences. Neuroprotective therapies designed to ameliorate these metabolic abnormalities are also being evaluated in clinical trials. A key feature of all these clinical trials is the rapid initiation of therapy. In the future, we can anticipate combined therapy trials with both neuroprotective and thrombolytic drugs, an approach which is likely to be more beneficial than either one in isolation.

ISSN:0014-3022    

DOI:10.1159/000117082

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000119491

出版商:S. Karger AG    

年代:1995

数据来源: Karger

摘要:

Alzheimer disease (AD), the major form of senile dementia, is rapidly becoming a major health problem in developed countries since as populations live longer the number of elderly people continues to grow. Simultaneously, the number of AD cases is increasing since AD is mainly a late-onset disorder and since no effective therapies are available. The primary causes of AD have not yet been elucidated. However, several researchers in different disciplines are actively engaged in AD research with one ultimate goal, i.e. trying to understand the disease pathology. Knowledge of the biochemical basis of the disease may eventually lead to a therapy which either prevents AD or allows AD patients to be treated. One such discipline is molecular genetics. The aim of molecular genetic studies is to identify genes that are either responsible for or contribute to the expression of AD. Once such a gene is identified, studies of its normal and/or abnormal gene product may help us understand the primary disease mechanisms and lead to more effective therapy. Currently, 3 genetic loci have been identified that predispose to AD: AD1 on chromosome 21, AD2 on chromosome 19, and AD3 on chromosome 14. This review aims at summarizing the progresses that have made in identifying genes and gene mutations that predispose to AD.

ISSN:0014-3022    

DOI:10.1159/000117083

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000119493

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000119494

出版商:S. Karger AG    

年代:1995

数据来源: Karger

摘要:

Thirty-two patients with hemispheric stroke lesions of distinct cortical functional zones (premotor, precentral, parietal) or of striatocapsular or striato-thalamic subcortical territories were scored at the acute and chronic stage for the following sensorimotor arm-hand functions: force, praxis, motor attention, sensation and dexterity. The selection criterion was that in spite of the wide variation of lesion sites all patients had hemiparesis as the presenting clinical sign. Analysis of the scores showed that most patients showed apraxia, motor neglect or disturbed sensation in addition to hemiparesis. The distribution and severity of these deficits varied, so that different lesion groups showed different patterns. The actual functional impairment of arm-hand function was determined by the combined effect of these different sensorimotor dysfunctions.

ISSN:0014-3022    

DOI:10.1159/000117084

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000119495

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000203033

出版商:S. Karger AG    

年代:1914

数据来源: Karger