摘要:

In the present work, on the basis of an unselected collection of patients suspected of epilepsy, the diagnostic value of waking and sleep recordings each after 24 h sleep deprivation are compared with one another. Indicative findings of epilepsy were found in 16.7 % of the cases in the waking EEG after sleep deprivation. In the sleep EEG after sleep deprivation this amounted to 57.1 %. These figures speak for the advantage of the second method. The result is highly significant with a x2 value of 13.01 (p < 0.01).

ISSN:0014-3022    

DOI:10.1159/000114829

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In six patients suffering from a multifocal neurological disease of the demyelinating type, a somatosensory evoked response was analyzed in the cortical and cervical area after stimulating the right index finger and the right nervus suralis. The results of the investigation with this method indicate that localization of the central nervous system pathology seems to lie within the realms of possibility, in which case this method will be a useful addition to the tools used to evaluate quantitatively the results of different treatments in this type of disease.

ISSN:0014-3022    

DOI:10.1159/000114800

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A report on a patient who developed profuse fasciculations following diphenylhydantoin therapy for 30 months with subsequent complete recovery on cessation of therapy is presented. In view of the considerable variability of spontaneous potentials generated in spinal motor neurones, in vitro studies and pathological states with respect to shape, amplitude, frequency and duration, caution is advised in the assessment of the clinical significance of fasciculations. The possibility that our patient represents an instance of a ‘reversible form of motor neuron disease’ is entertai

ISSN:0014-3022    

DOI:10.1159/000114801

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In a group of 65 epileptic outpatients the reliability of intake of prescribed medication was evaluated according to two criteria. The following results were obtained: the number of patients with no or irregular intake of antiepileptic drugs in the whole group was 28 %; the relationship between dose and observed plasma levels in patients reliable to intake could be verified; physicians were more often aware of unreliable intake by their patients than could be expected by chance.

ISSN:0014-3022    

DOI:10.1159/000114802

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Clonazepam at the average daily schedule of 3 mg in three single doses shows a satisfactory result on the tremor of about half of 15 treated parkinsonian patients.

ISSN:0014-3022    

DOI:10.1159/000114803

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The effects of di-n-propylacetic acid (DPA) on sleep, for some years used as an anticonvulsive drug, has been investigated in 11 healthy volunteers using all-night sleep EEG recordings. DPA acts by an enhancement of the gamma-aminobutyric acid (GABA) level of the brain. Its influence on sleep seemed to be of interest on account of the metabolic relationship of GABA to other short chain fatty acids. After short-term application only a shortening of the time to fall asleep and of the waking time could be found, whereas under long-term administration a decrease in deep synchronous sleep could be observed. In contrast to the results known from animal studies no marked influence on REM sleep was observed. The action of DPA on sleep is similar to that of diphenylhydantoin. No so-called matitudinal ‘hangover’ could be revealed in either d

ISSN:0014-3022    

DOI:10.1159/000114804

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In a series in 8 cats, cerebral perfusion pressure (CPP) was evaluated over a period of 5 min after production of an acute arterial hypertension. The mean percentual increase of blood pressure, CPP and ICP equalled 100%. The fact, that ICP does not play any role in acute hypertension, indicates that an abrupt elevation of filtration pressure within the capillaries must be the decisive factor leading to edema.

ISSN:0014-3022    

DOI:10.1159/000114805

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The results of the study of the activity of platdet monoamine oxidase (MAO) in patients with migraine headaches or with ‘cluster headaches’ are presented. In both types of headaches, MAO activity is lower than in normal subjects. We suggest that the low MAO activity is due to a primary constitutional def

ISSN:0014-3022    

DOI:10.1159/000114806

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219267

出版商:S. Karger AG    

年代:1904

数据来源: Karger

摘要:

A study is reported of the brain glycoproteins and the glycosaminoglycans in a case of infantile metachromatic leucodystrophy, associated with a ponto-cerebellar systemic atrophy, verified by autopsy. The glycosaminoglycan concentrations in the grey matter were within the normal range, while in the white matter they were slightly increased. The glycopeptides from the soluble and insoluble glycoproteins of white matter were altered not only in their quantity but also in their composition. In the grey matter a decrease of all sugars except the NaNa was detected in the insoluble fraction while in the soluble no change was detected, except for a threefold increase of fucose. The relationship was discussed of soluble to insoluble glycoproteins, and a mechanism for their derangement in MLD was suggested.

ISSN:0014-3022    

DOI:10.1159/000114807

出版商:S. Karger AG    

年代:1977

数据来源: Karger