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1. |
Ueber Wernickes Einfluß auf die klinische Psychiatrie. pp. 1–8 |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 1-8
H. Liepmann, Prof. Dr.,
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ISSN:0014-3022
DOI:10.1159/000203286
出版商:S. Karger AG
年代:1911
数据来源: Karger
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2. |
Third Interim Report of the Nationwide Collaborative Study on the Long-Term Effects of Bromocriptine in the Treatment of Parkinsonian Patients |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 3-8
Takao Nakanishi,
Ichiro Kanazawa,
Ikuo Goto,
Makoto Iwata,
Hisayuki Kowa,
Tohru Mannen,
Yoshikuni Mizuno,
Hiroshi Nishitani,
Norio Ogawa,
Akira Takahashi,
Kunio Tashiro,
Hideo Tohgi,
Nobuo Yanagisawa,
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摘要:
The interim results obtained up to the end of the 3rd year of the multicenter nationwide cooperative study on the long-term effects of bromocriptine in parkinsonian patients are reported. Bromocriptine monotherapy could be continued in approximately 33% of the patients at the mean maintenance dose of 11.4mg/day. The combined use of bromocriptine (11.1 mg/day) in parkinsonian patients already treated with levodopa had a favorable influence on the long-term side effects of levodopa such as the on-off phenomenon and dyskinesia. The beneficial effects of bromocriptine, levodopa and an early combination on parkinsonian symptoms such as rigidity and tremor remained at the end of the 3rd year. However, the effects of each mode of therapy on another parkinsonian symptom, akinesia, ceased by the end of the 3rd year.
ISSN:0014-3022
DOI:10.1159/000117167
出版商:S. Karger AG
年代:1990
数据来源: Karger
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3. |
Pseudotumor Cerebri following Eclampsia |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 6-8
B.S. Koppel,
A.M. Kaunitz,
A.J. Tuchman,
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摘要:
Pseudotumor cerebri, or increased intracranial pressure without a mass lesion, has been associated with hormonal activity but the exact causative relation is still obscure. We report a case of a 15-year-old girl who developed pseudotumor cerebri manifested by headache, visual symptoms and extraocular muscle palsies 3 weeks after recovering from eclampsia. Possible associations with eclampsia and postpartum changes in estrogen, progesterone and prolactin are discussed.
ISSN:0014-3022
DOI:10.1159/000116615
出版商:S. Karger AG
年代:1990
数据来源: Karger
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4. |
Ueber Wernickes Einfluß auf die klinische Psychiatrie. pp. 9–15 |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 9-15
H. Liepmann, Prof. Dr.,
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PDF (1912KB)
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ISSN:0014-3022
DOI:10.1159/000316486
出版商:S. Karger AG
年代:1911
数据来源: Karger
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5. |
Magneto-Electrical Stimulation of Central Motor Pathways Compared with Percutaneous Electrical Stimulation |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 14-18
Yoshikazu Ugawa,
Nobuo Kohara,
Tomoyuki Shimpo,
Toru Mannen,
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摘要:
The central motor conduction to the relaxed muscles was studied in 30 normal volunteers using magneto-electrical stimulation (MES) of the central motor pathways. The results were compared with those obtained by the percutaneous electrical stimulation technique (PES) described previously. None of the cortical and spinal latencies (Lcor and Lsp, respectively) and the central motor conduction time were different between MES and PES in the upper limb muscles. In some lower limb muscles, however, the Lsps of MES were significantly shorter than those of PES. This was probably because the magnetic stimulation over the lumbar spinal column activated the motor roots at their exit from the spinal canal rather than the level of conus medullaris, at which activation occurs in the electrical stimulation.
ISSN:0014-3022
DOI:10.1159/000116617
出版商:S. Karger AG
年代:1990
数据来源: Karger
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6. |
Dopamine Transporter: Biochemistry, Pharmacology and Imaging |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 15-20
Michael J. Kuhar,
Patricia M. Sanchez-Roa,
Dean F. Wong,
Robert F. Dannals,
Dimitri E. Grigoriadis,
Robert Lew,
Michele Milberger,
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摘要:
In recent years, there has been substantial progress in studying the dopamine transporter, a unique component of the functioning dopaminergic nerve terminal. The transporter has been studied by direct binding techniques using a variety of ligands which function as inhibitors of transport. Analogues of these ligands have been used as photoaffinity labels to solubilize and further characterize the transporter. While a variety of drugs bind to the transporter, it is clear that the transporter may serve as an important drug receptor, particularly for the reinforcing properties of some psychostimulants such as cocaine. An extension of the in vitro ligand-binding studies reveals that it is possible to preferentially label the transporter in vivo. The success of in vivo labeling has lead to successful positron emission tomographic scanning studies of the transporter. These studies in turn have revealed the usefulness of imaging the transporter, a measure of the presence of dopaminergic nerve terminals, as a potential diagnostic tool in Parkinson’s diseas
ISSN:0014-3022
DOI:10.1159/000117169
出版商:S. Karger AG
年代:1990
数据来源: Karger
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7. |
Ueber Wernickes Einfluß auf die klinische Psychiatrie. pp. 16–32 |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 16-32
H. Liepmann, Prof. Dr.,
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PDF (2444KB)
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ISSN:0014-3022
DOI:10.1159/000203287
出版商:S. Karger AG
年代:1911
数据来源: Karger
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8. |
Propranolol Corrects the Abnormal Catecholamine Response to Light during Migraine |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 19-22
Emilian Stoica,
Olimpia Enulescu,
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摘要:
The catecholamine (CA) response to light before and after propranolol therapy was studied in 25 migrainous subjects. Before therapy an abnormal CA response to light consisting of a rise in epinephrine excretion and a depression in norepinephrine (NE) excretion was noticed in migrainous patients. After propranolol administration (60 mg daily for 10 days) the post-photic augmentation in epinephrine excretion and the post-photic depression in NE excretion no longer occurred. As epinephrine discharge may be pathogenetic for migraine attack, the favorable effect of propranolol in migraine therapy could be due to its ability to prevent the epinephrine release induced by light or other stimuli.
ISSN:0014-3022
DOI:10.1159/000116619
出版商:S. Karger AG
年代:1990
数据来源: Karger
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9. |
Parkinson’s Disease: Neurotransmitter and Neurotoxin Receptors and Their Genes |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 21-30
George R. Uhl,
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摘要:
Studies of the changes in brain neurotransmitter and neurotoxin receptors in Parkinson’s disease now provide information about the state of many receptors. The status of dopamine receptors in the striatum, the possibility that specific neurotoxin receptors exist and the likelihood that receptors in other brain regions, including pathologically involved substantia nigra and cerebral cortex, can provide meaningful information about brain function and the disease are reviewed. Increasing information about these receptors is also available from molecular biological studies of dopamine receptors, and of genes encoding several of the putative candidate sites for possible neurotoxin action. Such approaches are providing an increasingly important perspective on Parkinson’s disease therapeutics and possible pathogene
ISSN:0014-3022
DOI:10.1159/000117170
出版商:S. Karger AG
年代:1990
数据来源: Karger
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10. |
Double-Blind Study of Nimodipine in Non-Severe Stroke |
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European Neurology,
Volume 30,
Issue 1,
1990,
Page 23-26
Julien Bogousslavsky,
Franco Regli,
Véronique Zumstein,
Werner Köbberling,
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摘要:
We evaluated the effect of nimodipine (30 mg q.i.d. orally for 14 days) on acute ischemic stroke of mild or moderate severity in a unicenter, double-blind, randomized, placebo-controlled pilot study. Treatment had to be started after CT, within 48 h of infarct in patients with a Mathew scale sum score between 50 and 75. The duration of follow-up was 4 months. Eight of the 60 randomized patients were excluded because of incorrect diagnosis. For the remaining 52 patients, 24 were allocated to nimodipine and 28 to placebo. Analysis of variance and covariance and repeated measurements of the Mathew scale scores showed no difference between the two groups, who had continuous and parallel improvement. There was no recurrent stroke, but 1 control died 4 weeks after stroke. Treatment with nimodipine was well tolerated (hypotension: 1 treated patient, 3 controls; bradycardia: 1 treated patient, 2 controls; sGPT increase: 1 treated patient, 1 control). The lack of efficacy of nimodipine in this study may be due to: (1) the neurologic deficit not being severe enough, or (2) the delay before treatment was too long.
ISSN:0014-3022
DOI:10.1159/000116620
出版商:S. Karger AG
年代:1990
数据来源: Karger
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