摘要:

Peripheral blood from 21 patients with active and 19 patients with stable multiple sclerosis (MS), and cerebrospinal fluid (CSF) from 7 of the patients with active disease were examined for T lymphocytes by rosette formation with sheep erythrocytes. Increased numbers of T cells were found in CSF in active disease (94.0 ± 0.7 compared to 71.3 ± 4.4% in controls). Decreased relative and absolute numbers of T cells were found in peripheral blood in active, but not in stable disease (mean 47 ± 3 and 957 ± 93%/mm3 compared to 66 ± 2 and 1,381 ± 93%/mm3 in cont

ISSN:0014-3022    

DOI:10.1159/000114925

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The absolute electrophoretic mobility of erythrocytes from MS patients is reduced in the presence of 0.08 mg/ml of linoleic or arachidonic acid, whilst that of normal or other neurological disease patients is increased in the presence of these acids. When an MS patient ingests γ-linolenate (in capsule form equivalent to 413.4 mg of γ-linolenic acid and 2.664 g of linoleic acid per day) the reaction of MS erythrocytes begins to change. After 3 or 4 months the reaction becomes normal with arachidonic acid (i.e. mobility is speeded up) and 2 months or so later this occurs also with linoleic acid. Very prolonged administration of γ-linolenate leads to a markedly increased sensitivity to the effect of prostaglandins (PGE2) on RBC mobility. The observations are interpreted to mean the induction of a biochemical-biophysical change in the membranes, and the significance of this in the aetiology and treatment of multiple sclerosis is discuss

ISSN:0014-3022    

DOI:10.1159/000114926

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Simultaneous serum and CSF IgM determinations were made by electroimmunodiffusion in 5 normals and 203 patients. Absent from normal CSF, IgM was found in 56 patients (27%): (1) A blood-CSF transudation was present in 25 patients (12%). IgM seems of no diagnostic value in these cases. (2) A purely local synthesis was demonstrated in 17 patients (8%), concerning proved (bacterial, viral, parasitic) or supposed (multiple sclerosis) persistent infectious aggressions. (3) In the last 14 patients with IgM in CSF, a transudation was associated with a local synthesis of IgG (meningitic pattern). (4) A ratio IgM 103 /albumin above 10 seems an argument for multiple sclerosis.

ISSN:0014-3022    

DOI:10.1159/000114927

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The concentration of cyclic adenosine 3’,5’-monophosphate (cAMP) was measured in cisternal cerebrospinal fluid (CSF) of male and female rats after electroconvulsive shock. cAMP levels were found to be increased compared to sham-treated controls for several hours following electroconvulsive shock with maximal increases of 46.8% in male and 17.2% in female rats. Old rats (300–360 g body weight) showed higher baseline concentrations than younger rats (180–250 g). In both groups female rats tended to have higher cAMP levels than ma

ISSN:0014-3022    

DOI:10.1159/000114928

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Surface markers of cerebrospinal fluid (CSF) cells have been studied in comparison with those of peripheral blood lymphocytes. The great majority (about 95%) of CSF cells bear surface markers of thymus-dependent lymphocytes (E rosettes with uncoated sheep red blood cells), while being devoid of bone-marrow derived cell markers (EAC rosettes with complement-coated red blood cells). In contrast with lymphocytes from peripheral blood, CSF cells form predominantly ‘early’ and ‘sphere’-shaped E rosettes, and bear receptors for the complement-fixing segment of immunoglobulins G. Treatment with concentrated CSF does not affect rosette forming ability of peripheral blood lymp

ISSN:0014-3022    

DOI:10.1159/000114929

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

23 patients with advanced Parkinson’s disease were allocated in a double-blind study of bromocryptine. These patients had an insufficient or deteriorating response to levodopa treatment. The dosages of levodopa were optimal and stabilized 3 months prior to and during this 5-month study. The addition of bromocryptine in high doses (average daily dose 71 mg) induced a significant improvement in the total score of the Webster and the NUDS scales. The global assessment, both by the investigator and by the patients, also showed significant improvement. The efficacy of bromocryptine in these type of parkinsonian patients in a double-blind trial has not yet been established. The conclusion of this trial is that bromocryptine significantly increases the therapeutic effectiveness in these poorly levodopa responding parkinsonian patient

ISSN:0014-3022    

DOI:10.1159/000114930

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219145

出版商:S. Karger AG    

年代:1905

数据来源: Karger

摘要:

The cerebral hemodynamic action of Vincamine is measured in 17 patients with primary or secondary cerebral circulation disorders, by use of the multiregional 133Xe clearance technique. The statistical analysis of the results justifies the grouping of all the cases and the distinction between reference, ischemic and hyperemic zones by determining for each subject a range of + or –15% of his own mean regional cerebral blood flow. The drug, in a single injection in the internal carotid artery, shows a significant beneficial hemodynamic effect on the ischemic regions of the brain. No steal phenomenon is recorded in the middle cerebral artery territory. The action of the drug leads to a decrease and an equalization of the hemodynamic resistances of the cerebral vascular be

ISSN:0014-3022    

DOI:10.1159/000114931

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A case of relapsing polyneuritis in a cirrhotic woman with a surgical splenorenal shunt is reported. The ultrastructural study of the nerve biopsy shows widespread segmental demyelinization with total myelin breakdown in most fibers; some Schwann cells are invaded by mononuclear cell processes. Such histological changes are characteristic of the Guillain-Barré syndrome. Alcohol and diabetes are unlikely to be the causative factors of the nerve damage. The possible role of unidentified toxic metabolites such as those which cause portosystemic encephalopathy, also present in our patient, is discussed

ISSN:0014-3022    

DOI:10.1159/000114932

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219146

出版商:S. Karger AG    

年代:1905

数据来源: Karger