ISSN:0014-3022    

DOI:10.1159/000118531

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

The nationwide multicenter collaborative study for evaluating the monotherapy of Parkinson’s disease with bromocriptine for a period of 5 years from 1986 was reviewed last year. The present report summarizes the follow-up in its 6th year: it includes 30 patients with Parkinson’s disease who continued to receive bromocriptine monotherapy for 6 years and 66 patients who received bromocriptine-levodopa combination therapy during the same period. The mean daily dose of bromocriptine in the 6th year was about the same in the two groups (11.9 and 12.2 mg). In terms of Hoehn-Yahr’s severity grade, severity increased in 20% of the patients undergoing bromocriptine monotherapy, whereas of the patients in the bromocriptine-levodopa combination group it was 45%. Wearing-off phenomenon was not seen in the bromocriptine monotherapy group. By contrast, 30% of the patients in the combination therapy group manifested this phenomenon which, when it occurred, invariably followed the administration of levodopa. Absence of the wearing-off phenomenon implies that bromocriptine has a direct protective action on degenerating substantia

ISSN:0014-3022    

DOI:10.1159/000118532

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

A 76-year-old, right-handed man developed posttraumatic dural arteriovenous fistula (DAVF) involving the superior sagittal sinus. He developed slow but progressive intellectual deterioration and gait disturbance after a minimal head trauma. Cerebral angiography demonstrated a DAVF of the superior sagittal sinus with sinus thrombosis supplied by branches of the bilateral external carotid arteries, and a DAVF of the right sigmoid sinus supplied by the right occipital artery. Selective embolization was carried out. He showed marked improvement on neuropsychological testing, especially on test items which are supposed to tap functions of the right cerebral hemisphere which showed an improved cerebral blood flow. We concluded that the intellectual impairment of our patient was caused by cerebral hypoperfusion, especially of the right cerebral hemisphere.

ISSN:0014-3022    

DOI:10.1159/000116889

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Idiopathic parkinsonism (Parkinson’s disease) makes up the largest diagnostic subgroup of patients with parkinsonism. Various hypotheses exist regarding the pathogenesis of idiopathic parkinsonism: these include genetic predilection, aging, environmental factors, oxidative stress, excitotoxicity, autoimmunity, and trauma. We suggest that the pathogenesis of idiopathic parkinsonism is likely to be multifactorial, deriving from environmental factor(s) acting upon a genetically predisposed individual. Because of the compelling evidence indicating common clinical and pathological findings in idiopathic parkinsonism, Alzheimer’s disease, and amyotrophic lateral sclerosis, we believe that these conditions result from pathological processes with more similarity than diversity. A primary glutamatergic cell neocortical abnormality provides an attractive unifying explanation which may explain the overlapping abnormalities found in idiopathic parkinsonism, Alzheimer’s disease, and amyotrophic lateral scle

ISSN:0014-3022    

DOI:10.1159/000118533

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We report a patient with recurrent cardioembolism and hemorrhagic infarcts, who developed a fatal intracerebral hemorrhage 3 days after intravenous anticoagulation. At autopsy, cerebral amyloid angiopathy (CAA) was found. Because CAA and anticoagulation may add up to trigger cerebral hemorrhage, the possibility of underlying CAA should be raised before anticoagulating elderly patients with stroke.

ISSN:0014-3022    

DOI:10.1159/000116890

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

A 47-year-old woman affected by systemic lupus erythematosus (SLE) presented with headache, fever, splenomegaly and edema of the lower extremities. CT showed diffuse low density in the cerebral white matter and marked splenomegaly in the abdomen. T2-weighted MR images showed diffuse high intensity lesions in the white matter. After immunosuppressive therapy with prednisolone, there was marked improvement in the cranial CT and MR appearances. The underyling pathological process was probably edema secondary to a lupus microangiopathy. SLE can be complicated by a widespread abnormality of the white matter with marked radiological changes but few neurological signs. In the present case, only an episodic mild hemiparesis for 3 weeks without seizure and psychiatric disturbance was found neurologically during the whole clinical course.

ISSN:0014-3022    

DOI:10.1159/000116891

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

A 29-year-old woman developed a seronegative myasthenia gravis. A thorax CT scan demonstrated an anterior mediastinal mass. Thoracotomy showed a lymphofollicular thymic hyperplasia and Hodgkin’s disease of the nodular sclerosing type with mediastinal lymph node localisation. This patient’s brother had been suffering as well from Hodgkin’s disease. Epidemiological similarities (genetic influences and the role of a viral agent) between Hodgkin’s disease and myasthenia gravis and the immune abnormalities found in these two diseases suggest that their association is not for

ISSN:0014-3022    

DOI:10.1159/000116892

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We report a 52-year-old man with idiopathic thrombocytopenic purpura accompanying acute oculomotor nerve palsy. At autopsy, intraneural hemorrhage was found in the cavernous portion of the oculomotor nerve. Intraneural bleeding as well as extraneural compression by hematoma formation should be considered as a cause of neuropathies occurring in patients with aggravated thrombocytopenia.

ISSN:0014-3022    

DOI:10.1159/000116893

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000203080

出版商:S. Karger AG    

年代:1913

数据来源: Karger

摘要:

To contribute to the undecided question if a retrovirus of the human T-cell lymphotropic virus (HTLV) family may be involved in the development of multiple sclerosis (MS), we investigated by the polymerase chain reaction (PCR) the presence of HTLV-I and HTLV-II sequences in the peripheral blood mononuclear cell DNAs from 30 patients affected by MS and 15 by chronic progressive myelopathy. Moreover a control group of 14 blood donors was examined. All these patients were devoid of anti-HTLV-I antibody in the serum and cerebrospinal fluid at ELISA. For the PCR, primers and probes specific for the tax region common to HTLV-I and HTLV-II, for the pol region of HTLV-I, and for the pol region of HTLV-II were used. In spite of the high sensitivity of the technique used, the three groups of subjects were negative for HTLV-I and HTLV-II genomic sequences.

ISSN:0014-3022    

DOI:10.1159/000116894

出版商:S. Karger AG    

年代:1993

数据来源: Karger