ISSN:0014-3022    

DOI:10.1159/000211559

出版商:S. Karger AG    

年代:1907

数据来源: Karger

摘要:

Heretofore unreported findings in skeletal muscle in a 4th case of pure postganglionic dysautonomia are described. They consist of variation in fiber size, Z line and myofilamentous disorganization, intracytoplasmic inclusions and honeycomb formations. The most striking alteration, however, was excess lipid accumulation without concomitant mitochondrial alterations. Sural nerve histology and cytology were normal. The mechanism of lipid accumulation in skeletal muscle of patients with dysautonomia remains unexplained.

ISSN:0014-3022    

DOI:10.1159/000115448

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000211560

出版商:S. Karger AG    

年代:1907

数据来源: Karger

摘要:

21diabetic patients were examined neurologically and neurophysiologically and were divided into two groups: one with neuropathy (10 patients) and the other without neuropathy (11 patients). Ultrastructural dimensions and density of capillaries in the gastrocnemius muscle were examined in 11 patients. Capillary basement membranes were significantly thicker in patients with neuropathy (p < 0.05), whereas there was no difference in endothelial, luminal or pericytial fractions of the total capillary area. No difference was found in capillary densities or capillary/fiber (C/F) ratios. Muscle blood flow was estimated using the 133Xe clearance method in all the patients, and was found to be reduced in the 4 patients with the most severe neuropathy (p < 0.01) even though there was no difference on the whole between the groups with or without neuropathy. The results suggest that the development of diabetic neuropathy is associated with basement membrane thickening. The causes of the basement membrane thickening are discussed.

ISSN:0014-3022    

DOI:10.1159/000115449

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Intradermal injection of 0.5 ug histamine produced equal skin reactions in normal individuals (n = 15) and in diabetic patients with (n = 10) or without (n = 9) evidence of autonomic neuropathy as well as in patients after lumbar sympathectomy (n = 5). Addition of noradrenaline (0.1 µg) resulted in a significantly smaller skin reaction (mean ± SEM) in normals (101.9 ± 10.1 vs. 136.3 ± 6.5 mm2, p < 0.005) and in diabetic patients without autonomic neuropathy (101.8 ± 8.4 vs. 123.9 ± 8.7 mm2, p < 0.05), but remained unchanged in diabetic patients with autonomic neuropathy (131.0 ± 9.0 vs. 130.7 ± 8.2 mm2, n.s.) and after lumbar sympathectomy (135.2 ± 17.5 vs. 130.2 ± 19.6 mm2, n.s.) when compared with the reaction to histamine alone. Addition of terbutaline produced similar results as observed with noradrenaline. These findings suggest a defect at the adrenoceptor level in diabetic patients with autonomic neuropathy and in patients with lumbar sympathectomy. Thus, the combined intradermal injection of histamine and the adrenoceptor agonists noradrenaline or terbutaline represents a simple and useful test for identifying patients with impaired adrenergic

ISSN:0014-3022    

DOI:10.1159/000115450

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

16 patients with transient global amnesia (TGA) have been investigated by computer tomography. 3 had a completed stroke associated with the TGA. The findings of computer tomography were normal in 7 patients. Atrophy alone was seen in 2 patients. A single hypodense lesion was found in 6 patients; a bilateral lesion in 1 patient. All 3 patients with amnesic stroke showed a hypodense lesion in the CT.

ISSN:0014-3022    

DOI:10.1159/000115451

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Adenylate kinase (AK) activity and glutathione concentration were measured in cerebrospinal fluid (CSF) on three different occasions after the ictus in 16 patients with cerebral infarction. All patients displayed an unambiguous AK activity in their CSF within 48 h after the ictus while glutathione was present in 10 of the 16 patients. The mean AK activity among these patients was reduced by about 60% after 1 week and an additional smaller reduction took place after 3–4 weeks. The glutathione concentration in CSF of these patients showed a similar curve profile with time. The 9 patients who showed clinical signs of improvement had significantly lower values on all occasions for both AK and glutathione than those who did not improve or deteriorated. A corresponding reduction in AK activity with time was not observed in 3 patients with cerebral malignancies. The possibility was excluded that the enhanced AK activity in CSF was the result of an increased transfer of the enzyme from the plasma compartment. Instead a causal relationship was suggested between the appearance of AK in CSF and a disturbed brain cell metabolism. Repeated analyses revealed different curve profiles for ischemic and neoplastic brain lesions. The importance of sampling and handling the CSF material under standardized conditions is emphasize

ISSN:0014-3022    

DOI:10.1159/000115452

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000211561

出版商:S. Karger AG    

年代:1907

数据来源: Karger

摘要:

43-year-old man developed transverse myelitis following an infection with Mycoplasma pneumoniae. Among the uncommon neurological complications following infection with this organism, transverse myelitis has been reported rarely but may be more frequent than previously thought. Posterior spinal column involvement might result in a permanent neurological deficit despite the usually good prognosis.

ISSN:0014-3022    

DOI:10.1159/000115453

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

4 cases with an identical neuromuscular disorder are presented. The disorder was characterized by slowly progressive weakness and wasting of the proximal muscles together with either ocular or bulbar symptoms, fatigability, positive tensilon test, myasthenic response on repetitive nerve stimulations, elevated serum creatine phosphokinase, and neuropathic and myopathic muscle pathology. All the patients showed a fairly good response to anti-ChE medications and steroid administration. Serum creatine phosphokinase levels returned to normal values after steroid therapy. Myasthenia, polymyositis or other neuromuscular disorders were discussed in the differential diagnosis.

ISSN:0014-3022    

DOI:10.1159/000115454

出版商:S. Karger AG    

年代:1982

数据来源: Karger