ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16054.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16055.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Developments in recent years permit us to state the following principles which relate to percutaneous absorption. (1) The entire stratum corneum junctions as the rate‐limiting barrier in the skin. (2) For penetration from weak solutions, flux is directly proportional to the concentration of the penetrant in the solution which is presented to the cutaneous surface. (3) Flux increases as the solubility of the penetrant in the stratum corneum increases. (4) Flux increases as the mobility of the penetrant in the stratum corneum (diffusion constant) increases. (5) Flux decreases as the thickness of the membrane increases. (6) When concentrations in the presenting solution reach high values, flux is not proportional to concentration. (7) Flux through dermal tissue is much more rapid than flux through the stratum corneum.For substances which penetrate relatively rapidly, the major pathway through the skin for steady‐state conditions is directly through the cells of the stratum corneum. For very slowly penetrating substances, shunts, e.g., the appendages, may be the major pathway. Strongly polar and strongly non‐polar molecules probably travel via different “molecular” pathways.Even though many of these principles have evolved fromin vitroexperiments, it is reasonable to expect them to apply equally well toin viv

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16056.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb12848.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb12839.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The epidermal barrier unit is composed of cells of the keratinocytic, transitional, and horny layers. The epidermis often contains other dendritic, leukocytic, and neural cells in the intercellular spaces. The epidermal intercellular canals and epidermal phagocytosis are 2 routes of transepidermal and transcorneal passage of materials. Individual, regional, age, and species differences in epidermis may account for variations in cutaneous permeability. Mitotic rate may be the most significant factor in barrier productio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16057.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb12840.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Fourteen patients are described who, in the course of typical facial rosacea, developed papular lesions on the limbs similar in appearance to those on the face. In some cases the lesions were small and numerous; in others the individual lesions Mere large (up to 1 cm. in diameter) dark red or mauve and deeply set. The histology of these extra‐facial lesions resembles that of the facial lesions as far as the inflammatory cellular infiltrate is concerned but there is a more prominent vascular component.The relationship of these lesions to rosacea is discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15915.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb12841.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb12850.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY