ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb07996.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb07997.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

ANTIANDBOGBNS are substances which prevent androgens from expressing their activity at target sites. The inhibitory effect of these substances, therefore, would be differentiated from compounds which decrease the synthesis and/or release of hypothalamic (releasing factors) and anterior pituitary hormones (gonadotrophins, particularly luteinizing hormone) and materials which act directly on the gonads to inhibit biosynthesis and/or secretion of androgens.Substances possessing antiandrogenic activity are of practical as well as theoretical interest. Systemically active compounds of this class would be expected to benefit women suffering from certain types of hirsutism and men suffering from androgendependentprostatic tumors or benign prostatic hypertrophy. Local use of antiandrogenic compounds also could be of use in women with hypertrichosis, in prevention of certain types of male baldness, for the inhibition of facial hair growth in men, and for the treatment and/or prevention of acne in young men and women.This communication will be concerned with the biology of antiandrogens, particularly from the viewpoint of bioassay models that are available for prediction of useful therapeutic activity on human skin.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb07998.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb07999.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—In patients with atopic dermatitis, eczema and urticaria, systemic treatment with prednisone had no effect on the serum immunoglobulin E level (IgE) but improved their clinical condition. Neither was there any effect on the IgE level after the immunosuppressive, azathioprine. The increased level of IgE found in patients with atopic dermatitis was not seen in those who had been free from symptoms for more than a year even if they had a persistent or recurring eczema of the hands or nummular eczem

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02185.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—The responses to topical application of tetrahydrofurfuryl nicotinate (Trafuril) cream were studied using a continuous skin perfusion method in clinically uninvolved skin of patients with chronic urticaria and in control patients. Trafuril causes inflammation but also renders the skin susceptible to dermographism.In non‐urticarial subjects little pharmacological activity was detected during Trafuril inflammation or after stroking the skin to induce dermographism. This suggests that Trafuril causes inflammation by a direct effect on the cutaneous vasculature. By contrast in urticarial patients histamine was recovered more frequently than in non‐urticarial patients during Trafuril inflammation, both before and after the skin was stroked. Perfusates from urticarial subjects also contained unidentified smooth muscle contracting activity which was not due to histamine, kinins, serotonin or acetyl choline. These results suggest that the skin of patients with chronic urticaria releases histamine and some other pharmacological agents more readily than that of normal subjects in response to inflammation producing st

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02186.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb08000.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–The paired costovertebral organs of the hamster are presented as an assay for distinguishing direct topical activity from indirect activity subsequent to systemic absorption. Topical chlormadinone acetate and its chemical modifications 19‐nor‐chlormadinone acetate, Δ1−chlormadinone desacetate and Δ1−chlormadinone−16–17 acetonide were without demonstrable effect. Cyproterone acetate and Δ1−chlormadinone acetate showed questionable activity which does not seem to be primarily confined to a direct

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb08001.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb07985.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—Mouse skin is highly sensitive to irritants and to carcinogenic agents. Histochemistry has been used to demonstrate that the pattern in malignant growths is distinctively different from that in hyperplasia produced by irritants. Evidence is given to indicate that the altered pattern of metabolism can be discerned after a single application of the carcinogenic 3‐methyl‐TCQ (tricycloquinazoline) but that no significant alteration is induced by the non‐carcinogenic 2‐m

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02188.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY