摘要:

SUMMARYMeasurement of the resting electrical potential difference on the surface of the skin has been made on patients with suspected basal cell carcinoma. It was demonstrated that in fifty‐five lesions from fortynine patients, the mean electrical potential difference from thirty‐six basal cell carcinomas was found to be +11 mV, from nineteen benign inflammatory lesions it was found to be +2 mV, and from normal skin, contra‐lateral to the lesions in both groups, it was found to be −3 mV. All the measurements are relative to a reference electrode placed under the tongue. The difference between the means for the inflammatory lesions and for the normal skin was found to be statistically insignificant, but the difference between these means and the mean potential difference for the basal cell carcinoma group was found to be highly significant (P<0.1%). However, the populations overlap to such an extent as to make the measurement, in its present form, useless as a diagnostic te

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03026.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYTwenty‐five patients with clinically proven, patch test positive nickel dermatitis were studied with the lymphocyte transformation test (LTT). Serial dilutions of NiSO4were present in the lymphocyte culture. None of the controls showed lymphocyte blast transformation. In fourteen patients maximal incorporation of thymidine occurred at the highest dilutions (1:50,000–1:100,000). In eleven patients the highest incorporation occurred at the lower dilutions. The nature of the antigen responsible for the specific reaction remains unkn

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03027.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYFifty‐seven subjects, forty‐three with various combinations of atopic disease and fourteen non‐atopic controls, were studied using a battery of immediate skin test allergens and a radio‐immunoassay for serum Immunoglobulin‐E (IgE).The geometric mean serum IgE level (units/ml) was 50 in strictly nonatopic controls, 170 in atopic respiratory disease (ARD) patients, 320 in atopic dermatitis (AD) patients and 772 in those patients with both AD‐ARD. The marked elevation of the serum IgE in the latter group was not associated with respiratory disease activity and not closely correlated with extent of the dermatitis, but may relate to patients with both AD‐ARD being ‘highly atopic’.Overall, there was no correlation between the serum IgE level and the frequency of positive skin tests. Compared to ARD patients, the serum of AD patients contained more IgE, yet they reacted significantly less frequently to common ex

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03028.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe interaction of Concanavalin A (Con A) and the surface membranes of the epithelial cells of human oral mucosa, epidermis and guinea‐pig lip was studied. Two methods were used: fluorescent Con A and Con A in combination with horse radish peroxidase. With both methods the surface coat of epithelial cells was stained. The specificity of the staining methods could be demonstrated. The interaction between pemphigus antibodies and the surface membranes of epithelial cells could be blocked by Con

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03029.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYAntireticulin antibody was present in 17% of sera from thirty‐five patients with dermatitis herpetiformis, 45% from twenty‐eight patients with adult coeliac disease and none of thirty healthy controls.There was a higher incidence of antireticulin antibody (a) in patients on normal diets than in those on gluten free diets, and (b) in patients with subtotal villous atrophy than in those with partial villous atrophy. Two patterns of tissue staining were demonstrated, one of which was almost invariably associated with jejunal subtotal villous atrophy. The Ig class of the antibody was IgG in all instances but in 64% antibody of the IgA class was also pres

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03030.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYPlasma β‐MSH levels and sebum excretion rates (SER) were measured in thirty male and twelve female patients with acne vulgaris. The mean SER in both male and female patients was significantly increased as compared to normal control levels.Plasma β‐MSH levels were normal in male and female patients with acne and showed no correlation with the SER. The SER that occurs in acne cannot therefore be explained by an increased secretion of

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03031.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe reactions to monochromatic radiation of the skin of ten patients with xeroderma pigmentosum were investigated, and eight were abnormal. The abnormalities consisted of papular and vesicular reactions and delay in the development of the minimal erythema dose reaction with wavelengths principally in the 290‐320 nm range. Three patients were too young for full action spectra to be obtained but of those patients in whom all wavelengths were tested only one showed a reaction to radiation above 320 nm and this was at 340 nm only. In only one patient was the minimal erythema dose at 300 nm at 24 h lower than normal.In six patients the repair synthesis of deoxyribonucleic acid after ultraviolet radiation was estimated. Reduced levels were seen in five but repair was normal in one patient. The patient with normal repair also had normal reactions to monochromatic radiation.The abnormal reaction of the skin to artificial radiation and the abnormal deoxyribonucleic acid repair synthesis may enable the diagnosis of xeroderma pigmentosum to be made at a very early age. In one of the patients the diagnosis was made at the age of 6 months in a child with photosensitivity but with no other clinical signs of the disease. It is suggested that, by making the diagnosis as early as possible and by protecting the skin from natural sunlight, cutaneous malignancies may be prevente

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03032.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYApplication of dithranol confined to the normal skin surrounding thirty‐six psoriatic lesions produced improvement in twenty‐four lesions, which was significantly more than the improvement noted in four of thirty‐six control lesions left untreated. Such healing was temporary and slower than in lesions treated conventionally. It is suggested that the apparently normal skin around a psoriatic lesion under treatment influences the psor

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03033.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYDequalinium chloride is a topical antiseptic, whose use may be attended by skin necrosis. Since microcirculatory changes are an early and distinct manifestation of tissue injury, the tissue damaging effect of dequalinium chloride on the microcirculation was examined.The immediate vascular reactions were studied by vital microscopy of the hamster cheek pouch and the late effects were visualized by microangiography of the rabbit ear. An aqueous solution of dequalinium chloride in concentrations well below those used in clinical practice induced severe microcirculatory disturbances.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03034.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYNo significant difference was found between the plasma vitamin A levels of patients with dyskeratoti skin disease and those of comparable control subjects.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03035.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY