摘要:

SUMMARYThe main types of underlying mechanism in Raynaud's phenomenon were tested separately in thirty‐six patients. Within each of three groups of patients who were clinically classified according to strict definitions as having primary Raynaud's disease, systemic sclerosis or rheumatoid arthritis, there was pathophysiological heterogeneity. It is therefore suggested that in studies of treatment, at least when it is aimed primarily at one pathophysiological mechanism, the patients should be selected according to the mechanism rather than what is commonly done now, according to the associated disorde

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05664.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYBlood flow was measured in patients with Raynaud's phenomenon, systemic sclerosis and in normal controls by venous occlusion plethysmography on the forearm and calf, and changes in blood flow in the finger were followed by calorimetry.Intravenous naftidrofuryl oxalate (praxilene) improved blood flow to the skin of the finger as measured calorimetrically in seven of sixteen patients with Raynaud's phenomenon and systemic sclerosis. The drug markedly reduced blood flow in the finger in all ten normal control subjects. However, naftidrofuryl increased blood flow as measured by venous occlusion plethysmography in the leg both of normal subjects and of those with Raynaud's phenomenon. In addition to these findings, no significant change in blood flow in response to the drug was observed in the forearm. The reasons for these regional differences are discussed and considered to be due to redistribution of blood flow as a result of differences in pharmacological receptor activity in different parts of the body and possibly also due to effects of central control.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05665.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYT and B lymphocyte populations were evaluated in forty‐one patients with multiple recurring warts. Active rosettes (T‐Ea) and total T lymphocytes (T‐Et) were significantly decreased.Thein vitroeffect of a calf thymus extract (TP‐1) on peripheral blood lymphocytes was evaluated in thirty‐three patients. A statistically significant increase in E‐rosette forming cells was observed in twenty‐three patients (69%). Serum blocking factors were not found in the patients with a positive response to TP‐1, which suggests the possibility of a thymic hormone deficiency. In the case of non‐responders to TP‐1, on the other hand, an anti‐lymphocyte antibody capable of directly blocking the hormone receptors on the undifferentiated lymphocy

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05666.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYThe lysosomal enzymes, acid‐phosphatase and β‐glucuronidase, were released from rat liver lysosome when exposed to 400 nm irradiation in the presence of haematoporphyrin, and the release was prevented by adding vitamin E., diazabicyclo‐octane, bovine serum albumin, superoxide dismutase ord‐mannitol to the reaction mixture. Monochromatic irradiation with wavelengths from 380 to 410 nm caused no significant differences in the release of lysosomal enzymes, but 420 nm irradiation caused three fifths of that of 400 nm irradiation. The malondialdehyde level in rat liver homogenate increased after 400 nm irradiation in the presence of haematoporphyrin. Reduction of nitroblue‐tetrazolium was not observed when haematoporphyrin was excited by 400 nm; it was considered that superoxide anion radical (O–2) was not primarily generated.The following mechanism was assumed: that porphyrin which had been excited by 400 nm, converted ground‐state molecular oxygen (3O2) to excited singlet oxygen (1O2), which formed lipid peroxides in lysosomal membrane resulting in destruction of the membrane; skin changes would occur from these released lys

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05667.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYFifty patients with dermatitis artefacta were investigated psychiatrically over several years and twenty‐six of these were seen independently by a clinical psychologist.The psychological investigations suggest a personality structure characterized by inward‐looking self‐centred attitudes leading to increasing isolation.The psychiatric investigations suggest a background of emotional disturbances during the formative years and in later life often resulting in feelings of isolation and insecurity. The onset of dermatitis artefacta is very frequently related to definable precipitating events which vary according to age and life situations. The visible skin lesions can be understood as an attempt at non‐verbal communication subserving an appeal function.Therapeutic methods and prognosis are discussed in some

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05668.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYFour corticosteroids were testedin vitrofor effect on the proliferation of four strains of fibroblasts from scleroderma skin, four strains from normal adult skin and four strains of rheumatoid synovial cells.Significant effects on fibroblasts occurred only at the highest steroid concentration tested (10 μg/ml) where the inhibitory ranking of the steroids was clobetasol propionate>clobetasone butyrate>betamethasone valerate>hydrocortisone. Hydrocortisone and betamethasone valerate stimulated proliferation of two normal strains, had no certain effect on the scleroderma group, and inhibited growth of synovial cells. Clobetasone butyrate and clobetasol propionate inhibited growth of all cells. All four steroids substantially reduced acid mucopolysaccharide secretion by scleroderma fibroblasts.These results suggest that fibroblasts from normal and abnormal skin show only small differences in their responses to corticosteroidsin vitro, but contrast sharply with the mouse L‐929 fibroblasts previously used in some assays of topical corticosteroid poten

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05669.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYThe occurrence of low molecular weight (<500 dalton) eosinophil chemotactic factor (ECF) was studied in the blister fluid of patients with various dermatological diseases by anin vitrochemotaxis method. After chromatographic separation of the test substance on a small Sephadex G 25 column, ECF was demonstrated in blisters of five patients with bullous pemphigoid, in three patients with systemic drug reactions and in one patient with blisters after contact with primula. ECF was not found in blisters of patients with epidermolysis bullosa and herpes gestationis or in DNCB‐induced blisters. Fluid obtained from suction blisters was negative in normal controls and on unaffected skin of patients with atopic eczema, but contained ECF in eczematous areas. The demonstration of ECF in tissue fluid suggests that this factor plays a role in the local accumulation of eosinophils at sites of certain inflammatory reaction

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05670.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYNeutrophil function was studied in several patients with recurrent infections, mainly of the skin. Twelve patients showed impairment of neutrophil functions, either chemotaxis or bacterial killing and phagocytosis.Levamisole was given in four cases: improvement of neutrophil function and long‐lasting clinical remission occurred in three of them, whilst in the fourth the drug was not tolerated.Ascorbic acid was administered to three other patients, with satisfactory improvement of neutrophil function and long‐lasting clinical remiss

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05671.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYSerum total IgE levels were found to be increased in thirty‐nine of ninety‐four patients with scabies investigated at the time of clinical presentation. One hundred and fifty‐four patients were found to have a significantly lower serum concentration of IgA during infection than when measured 6 weeks and 9 months following successful treatment (P<0.05). The serum concentration of IgA at 6 weeks and 9 months after treatment did not differ significantly. The serum concentration of IgG during infection was significantly higher than 6 weeks later (P<0.05), and than 9 months later P<0.001). The 6 weeks levels were significantly higher than the results at 9 months (P<0.01). The serum concentration of IgM during infection was higher than 6 weeks later (P<0.1). The 6 weeks levels were lower than those at 9 months (P<0.1), whereas there was no difference between the pretreatment and 9 months levels. No differences were noted in the concentration of C3 and C4. Antinuclear antibodies (ANA) and rheumatoid factor (RF) were not found in any of the patients. In thirty‐two patients with lichen planus no changes in immunoglobulins or complement were observed.This suggests that scabies infection may be associated with a humoral immunological response against the scabies in

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05672.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYA technique for the isolation of human stratum corneum cells from any depth within the horny layer is described. Examination of the cells by light, scanning and transmission electron microscope permits a detailed morphological profile of the plasma membrane to be constructed. It is suggested that the technique will be of particular value in determining the effect of chemical agents on the cellular components of the horny layer.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb05673.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY