摘要:

SUMMARYFor the first time a method for culturing human hair follicle cells is described. The bovine eye lens capsule, a basement membrane‐like structure, is used as the substrate for the cultures. In a culture medium supplemented with hydrocortisone and insulin about 70% of the original follicles will form growing colonies of diploid keratinocyte

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01704.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe light, polarization and electron microscopic changes in the liver of four cases of erythropoietic protoporphyria (EPP) are described. In one of these cases liver involvement resulted in death, whereas in the other three there were no symptoms referable to hepatic disease. In two cases hepatic pigment was readily visible on light and polarization microscopy and corresponded to characteristic crystalline aggregates seen ultrastructurally. Pronounced micronodular cirrhosis and cholestasis were present in the fatal case, while in the other only mild periportal fibrosis and mononuclear inflammatory cell infiltrate occurred. The third and fourth cases showed no evidence of hepatic involvement on light microscopy. Electron microscopy, however, revealed characteristic crystal‐containing vacuoles indicative of protoporphyrin deposition. The need for early detection of the hepatic lesion is emphasize

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01705.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYMicroscopic studies have been performed on skin biopsies from five patients with occupational argyria.Small brown‐black granules were present in the dermis on light microscopy and were intensely refractile with dark‐field illumination. Electron microscopy showed that the granules were electron‐dense, round or oval in shape and varied in size from 30 nm to 100 nm. They were most numerous in relation to the basal lamina of the eccrine sweat glands, but were also present in relation to the basal lamina of the epidermis and dermal elastic fibres. X‐ray microanalysis confirmed that many of the granules contained silver and sulphur. However, selenium, mercury, titanium and iron were also identified and it is probable that these elements were deposited in the skin also as a result of occupational e

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01706.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYNo change in the weal and flare response to histamine was found after placebo and ‘aggro’, the former given double‐blind, the latter in a blind study. Placebo and ‘aggro’ actions may involve mechanisms other than the final response to mediators of inf

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01707.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYActivity of the enzyme acid α‐naphthyl acetate esterase (ANAE) in T lymphocytes and histiocytes in cutaneous tissue sections of patients with histologically confirmed lichen planus, chronic discoid eczema and mycosis fungoides was compared with results obtained using anin situimmunohistochemical technique employing an antiserum against the human T lymphocyte surface antigen (HTLA). In lichen planus and chronic discoid eczema, most of the cells in the cutaneous infiltrate exhibited both positive ANAE activity and the presence of HTLA. In mycosis fungoides, cells identified as T lymphocytes by the presence of HTLA often showed no ANAE activity. ANAE activity appears to be a useful marker of T lymphocytes in benign cutaneous infiltrates but is less reliable in labelling abnormal T cel

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01708.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe effects of the aromatic retinoid Ro 10‐9359 on the fine structure of psoriatic dermis were investigated by electron microscopy in five patients after 1, 2, and 3 weeks of treatment (1 mg/kg/day). Our findings show that aromatic retinoid, additionally to its epidermal effects, exerts a distinct influence on dermal components in psoriasis. Ultrastructural evidence is provided suggesting that this drug stimulates lymphocytes and monocytes, promoting their differentiation into Sézary‐like lymphocytic cells, activated macrophages and dermal Langerhans cells. The appearance of these immunocompetent cell lines may modulate the cell‐mediated immune response in psoriasis, obviously reflecting a pharmacological action of the drug additional to its definite influence on epidermal keratini

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01709.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYA quantitative study of 8‐methoxypsoralen plasma profiles in patients with psoriasis undergoing photochemotherapy shows that a poor response to the treatment may be explained in terms of abnormal pharmacokinetic behaviour. However, not all ‘poor responders’ exhibit an abnormal pattern and for these an alternative explanation is req

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01710.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYDapsone yielded excellent therapeutic results in certain forms of lupus erythematosus (LE), whereas discoid lesions and the maculo‐papular rash of the systemic and disseminated chronic forms of discoid LE remained uninfluenced by the drug. On the basis of these observations, we suggest the following indications for dapsone treatment in LE:1Vasculitic urticaria2Oral ulceratino3Non‐scarring form of chronic LE4Chloroquine intolera

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01711.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYA new human model for the evaluation of the atrophogenicity of topical corticosteroids is proposed. Formulated corticosteroids (creams and ointments) were applied occlusively to normal forearm skin of human volunteers for 3 weeks using Duhring chambers. Visible atrophy and telangiectasia were rated under a stereomicroscope on a histologically validated five‐point scale. There was a close correlation between the parameters of atrophy and telangiectasia. Atrophogenicity varied considerably among the tested corticosteroids, ranging from none (1% hydrocortisone) via moderate (0.1% betamethasone valerate) to very severe (0.05% clobetasol propionate). A dose‐response relationship with exposure time and concentration of the corticosteroid could be demonstrated. Furthermore, the vehicle influenced the resulting atrophy and telangiectasia. Fatty ointments seem to pose less risk than oil in water cre

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01712.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYFive patients with Behçet's disease were satisfactorily treated with colchicine. Oral aphthosis, erythema nodosum‐like lesions and genital erosions improved greatly within a month as did laboratory findings. We believe colchicine to be the first choice in the management of the cutaneous and ocular lesions of Behçet's dise

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb01713.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY