摘要:

SUMMARYPatients withTrichophyton mentagrophytesandT. rubruminfections were compared in terms of cutaneous responses andin vitrolymphocyte reactivity to trichophytin and other antigens. Twelve out of fourteenT. mentagrophytespatients exhibited delayed cutaneous hypersensitivity to trichophytin. MostT. rubrumpatients (thirty‐seven out of forty‐nine) lacked delayed reactions to trichophytin specifically, but these patients frequently manifested immediate weal reactions to this antigen. Positive lymphocyte responses correlated with the presence of delayed but not immediate cutaneous reactions. Serum from chronicT. rubrumpatients failed to inhibit lymphocyte responses. Possible mechanisms for selective anergy in chronicT. rubrumpatients are discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06355.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe replacement time of the human stratum corneum of fifteen body regions was determined by measuring the days required for a strongly substantive fluorescent marker, Dansyl chloride, to disappear. Tbe horny layer was stained by a 24‐h patch exposure to 5% Dansyl chloride (5‐dimethylamino‐ 1‐naphthalene‐sulphonyl chloride) in petrolatum.In most body regions the renewal time for the horny layer was about 2 weeks, in agreement with the findings of other investigators.The advantage of Dansyl chloride over another compound, tetrachlorosalicylanilide, which has been used for this purpose, is that it is not an

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06356.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe relationship between Civatte bodies and epithelial cells in mitosis was investigated in lichen planus lesions of the oral mucosa. The nuclear material in Civatte bodies was often very similar to that in normal dividing basal epithelial cells. In addition, cells were found with clearly identifiable chromosomes, but with cytoplasmic changes of Civatte bodies. These results suggest that Civatte bodies are probably the outcome of degenerative changes affecting epithelial cells in various stages of mitosis.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06357.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYExperimental scratching induced phloxinophilic eosinophilic bodies in unaffected skin of ten patients with active lichen planus. This reaction was inhibited by concomitant local injection of methylprednisolone acetate and could not be induced in patients with inactive lichen planus, in patients with other dermatoses, nor in healthy subjects. The findings are consistent with a viral aetiology for lichen planus.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06358.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYStandard wounds were produced on the palates of streptozotocin‐induced ‘diabetic’ and normal rats. Healing, as estimated by the extent of epithelial migration after 24 h, was found to be identical in the two groups. The accumulation of glycogen and PAS positive, diastase‐resistant material in the epithelium at the wound margins was far greater in the diabetic animals than in the controls. Indirect evidence is presented suggesting that the passage of glucose into epithelial cells is independent of insulin control.The investigation was planned to assess two aspects of wound healing in the mouths of ‘diabetic’ rats compared with normal controls:(1) The ability of epithelium to migrate across a wound.(2) The accumulation of glycogen in the epithelium at the wo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06359.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYCrude human skin extracts having tissue‐specific mitotic inhibitory activity (chalone), were studied by ethanol precipitation and disc gel electrophoresis. Precipitates obtained at various ethanol concentrations were dialyzed, lyophilized and tested for their mitotic inhibitory activity. It was found that the greatest inhibitory activity was concentrated in the precipitate formed in 81% ethanol, the active principle being concentrated about 200 times. Proteins in crude extracts were separated by disc gel electrophoresis, and at least eight bands were identified. Groups of bands were extracted from the electrophoretic gels and tested for their mitotic inhibitory activity. Fraction II, containing two bands, had the highest activity. Disc gel electrophoretic analysis of the 81% ethane precipitate revealed only two major bands, one of which could also be found in fraction II of the crude extract. This protein band, which is present in both of the mitotic inhibitory samples, may represent the human epidermal chalon

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06360.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYA 50‐year‐old woman, who probably had pre‐existing quiescent porokeratosis of Mibelli, suffered an abrupt and extensive eruption of porokeratosis in a systematized pattern 2 weeks after renal transplantation, while being treated with prednisolone and azathio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06361.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYA method is presented for simultaneous in vitro growth and measurement of permeability of human skin. During culture of specimens, the parakeratotic layer formed is shown to possess considerable barrier function. Maximum barrier capacity of this layer in vitro is attained at 14–17 days’ incubation. When the stratum corneum is removed prior to incubation, the maximum barrier capacity is reached in 3–4 days. The difference in behaviour between intact and stripped skin is reflected in the pattern of DNA synthesis of the basal cells, which show an enhanced proliferation after stripping. Barrier regeneration of stripped skin is seen closely to resemble the parallel situation in

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06362.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe numbers of dermatophytes isolated from specimens sent to a mycological diagnostic service in the West of England from i960 to 1970 are reported.An increasing rate of failure to culture from microscopically positive specimens is noted. One reason for this was the large number of nail clippings sent in unaccompanied by scrapings from skin lesions. The cultural failure rate from nail clippings makes the diagnosis of the causal fungi in onychomycosis very unsatisfactory. For treatment purposes, means of deducing the nature of these uncultured fungi by combining clinical and laboratory observations are proposed.It is suggested that two features of mycological diagnostic services—(a) failure to culture from a proportion of microscopically positive specimens, and (b) the fact that only the more severe, widespread and recalcitrant lesions are usually seen by dermatologists—result in a very misleading picture if these figures are used to assess the incidence of the various dermatophyte species in the general populat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06363.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe infected fingers in chronic paronychia were mostly on the dominant hand. Little fingers were less and middle fingers more affected than expected. Oral Candida albicans carriage was significantly less when the first finger to be infected was the middle finger. The duration of the disease was related to the number of infected fingers, but not to oral C. albicans carriage. The second finger to be infected was an opposite* or adjacent finger more often than expected.The following conclusions are drawn: (i) The mouth and the bowel, but not the vagina, of the patient, or her family, are sources of C. albicans in chronic paronychia. (2) Mechanical trauma that destroys the cuticle is responsible for the invasion of C. albicans into the nail‐fold. (3) This trauma in our patients is mostly due to rubbing during hand‐washing of clot

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06364.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY