ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06666.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA woman manifested lichen amyloidosus of the right lower limb and macular amyloidosis of her left leg with congenitally impaired cutaneous sensation. Another patient had bilateral lichenoid amyloidosis of her legs. Unilateral triamcinolone injections produced the picture of macular amyloidosis in the treated leg. Light and electron microscopic studies of biopsies from both patients showed similar amyloid deposits in the papillae; the significant difference was epidermal hyperplasia in the lichenoid lesions. We suggest the term biophasic for the existence of both macular and lichenoid amyloidosis in the same patient.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06667.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYDiffuse loss of scalp hair occurs in some women when they stop taking mixed oestrogen/progestogen oral contraceptives. Nine women had diffuse alopecia while still continuing to take the pill. The relationship between the hair thinning and oral contraceptives is discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06668.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe epidermis in lichen planus presents an apparently paradoxical situation. There are on the one hand epidermal hypertrophy acanthosis and hypergranulosis, and on the other, destruction of the generative compartment with erosion of the basal layer. In order to understand how the two processes can co‐exist, thirty‐five lichen planus papules from twenty‐five patients were injected intracutaneously with IO μ Ci of tritiated thymidine. Sixteen of these lesions were removed after 50‐60 min and nineteen were removed after longer intervals of up to 10 days. Autoradiographs prepared from biopsied lesions demonstrated that keratinocytes had migrated into the lichen planus lesion from the intact margins, replaced the eroded basal layer and repopulated the epidermis of the lesion. It is concluded that the changes observed in the epidermis seen in lichen planus can be interpreted as the result of a continuous process of (1) erosion and (2) repopulation in an attempt at healing of the woun

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06669.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYWe report inhibition ofin vitrosynthesis of prostaglandins by skin in the presence of aspirin and indomethacin. In the presence of aspirin significant inhibition of enzymic synthesis of prostaglandin F2α, but not prostaglandin E2, was demonstrated. Indomethacin also caused a significant inhibition of synthesis of prostaglandin F2α, but had no effect on prostaglandin E2synthesis. Since there is increasing evidence that prostaglandins mediate some types of inflammation, the possibility arises that inhibition of prostaglandin biosynthesis explains at least part of the anti‐inflammatory activity of these dr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06670.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe effect of polyphloretin phosphate (PPP) on the human cutaneous reaction induced by prostaglandin E1(PGE1) has been studied in thirty subjects. Pre‐treatment of the skin with three intradermal injections of 1oo μg PPP reduced by 37% the magnitude of the erythema induced by intradermal injection of 1 μg PGE1. The PGE1induced weal, which is probably mainly due to PGE1‐induced endogenous histamine release, was not reduced. The specific nature of the PG‐blocking activity of PPP was supported, since PPP did not block the erythema and weal induced by intradermal injection of histamine and bradykinin. Intravenous injection of 100 mg PPP did not reduce the erythema due to intradermal injection of PGE1probably because of too low tissue concentration

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06671.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYEighty‐four patients with alopecia areata of varying degree have been treated by intralesional injections of triamcinolone acetonide, using a needleless injector (Porto‐Jet). Results indicate that, in limited alopecia, a high proportion will produce a rapid regrowth of hair. In established alopecia totalis, lasting hair growth is exceptio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06672.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe spread of a drug from the site of application to other areas of skin may give rise to false interpretations in paired comparison tests of efficacy. In infected dermatoses treated with topical neomycin the placebo treated site improved clinically and there was almost as great a reduction in theStaphylococcus aureuspopulation. Applied to one axilla, topical penicillin engendered resistance among cocci in both axillae. Similarly, washing one axilla with a bacteriostatic soap greatly reduced the microflora in the opposite axilla. When potent antibacterial agents such as chloramphenicol or sodium pyridinethione were applied to a small area of forearm skin, there was sufficient translocation to the opposite side to prevent the great increase in the resident organisms which normally follows wrapping with impermeable plastic film.For highly potent substances, spread to distant untreated areas has to be considered as a source of error in therapeutic trials.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06673.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe dorsal skin of the hairless mouse when ‘stripped’ with sticky tape proved to be a suitable model for a study of the antimitotic effect of betamethasone‐17‐valerate and hydrocortisone. The application of 1%, betamethasone‐17‐valerate and 1%, hydrocortisone creams under occlusive dressings for 24 h produced a three‐ to four‐fold drop in the colcemid‐induced mitotic index as compared to a control application.The antimitotic effect of the betamethasone‐17‐valerate preparation started at or before 5 h and continued for at least 4 days after removal of the active material. It was shown in addition, that 1% betamethasone‐17‐valerate also reduced the number of cells entering DNA synthesis. The antimitotic effect of hydrocortisone was detected at a concentration of 10‐2and that of betamethasone‐17‐valerate was detected at a concentration of 10‐4. It is suggested that the animal model used is a useful one for assaying the potency of

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06674.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYEpidermal aryl hydrocarbon hydroxylase activity of homogenates from mice treated for 7 days with various topical corticosteroid ointments was significantly higher than in preparations from animals receiving steroid‐free ointment bases, or no treatment. As determined by 3,4‐benzopyrene oxidation, enzyme activity was also greatly increased 24 h after small doses of various polycyclic hydrocarbons given by the intraperitoneal route. Inhibition of enzyme activity was observed in skin homogenates from both control and treated animals following additionin vitroof 7,8‐benzoflavone, but not with dimethylsulph

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb06675.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY