ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05177.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYPositive tests for anti‐nuclear factor were found in 7% of 101 patients with psoriatic arthritis. In only one case was this at a significantly high titre. The overall prevalence is that expected in the community, though there was a high prevalence in those with Sjögren's syndrome. This is a further differentiating feature from rheumatoid arthrit

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05178.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe periodontal membrane is markedly involved in about 30% of patients with systemic sclerosis and some widening occurs in about 20% of the teeth at risk. Thickening of the periodontal membrane is not specific to systemic sclerosis and can occur with clinically obvious chronic periodontal disease and, to a mild extent, in normal individuals in whom it mainly involves the coronal third of the teeth. In systemic sclerosis the whole root is more likely to be involved. There is no direct relationship in systemic sclerosis between widening of the periodontal membrane and other systemic changes, and prognosis.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05179.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYA specially designed frame is being used in this laboratory to facilitate the isolation and handling of human cadaveric stratum corneum of the upper back. Although it is in the early stages of use, the ease of isolation and subsequent handling of the stratum corneum has prompted the writing of this short report.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05180.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05181.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYA survey of the incidence of molluscum contagiosum virion antigens in patients with single or multiple lesions showed that all lesions contain virus antigen. The virion antigens were detected in the prickle cell, granular and keratin layers. Hyperimmune sera against vaccinia, rabbit‐pox and mouse‐pox failed to stain the inclusion bodies in molluscum contagiosum lesions. Virus‐specific antibodies were present in 69% of the patients. Although virus‐specific IgG antibody was predominant, virus‐specific IgM and virus‐specific IgA were found in a few patients. An IgM staining in the prickle cell, granular and keratin layers of normal skin adjoining the molluscum contagiosum lesion was observed. The virusspecific antibody response was induced in a few patients after th

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05182.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYFour cases of herpes gestationis are reported and the immunopathological findings in these patients described. Complement deposition at the basement membrane zone of the patients' peri‐bullous skin was seen in all patients, immunoglobulin deposition in two. A circulating factor capable of fixing complement on the basement membrane zone of normal human skin was present in three patients. These findings are discussed and compared with the immunopathological findings in bullous pemphigoi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05183.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe appearance of the epidermis and epidermal autoradiographic labelling indices were compared in actinic keratoses and paralcsional skin in seventeen patients after injection of tritiated thymidine. The skin of the buttock area was also studied as a ‘non‐sun exposed’ control. Labelling indices obtained from skin removed after i h were as follows: actinic keratoses 17.4%; paralesional skin 11.2%; buttock skin 5.4%.Many of the epidermal cells in the keratoses that incorporated tritiated thymidine were bizarre and not restricted to the basal or suprabasal regions but were scattered through the thickness of the epidermis. Paralesional skin also showed epidermal thickening and cytological abnormalities including the formation of multinucleate epidermal cells. These findings suggest that the development of actinic keratoses takes place in epidermis that is itself abnormal. The changes suggest that there is a gradual stepwise progression of sun damaged epidermis via the clinically obvious keratosis to squamous cell epithe

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05184.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYA patient with epidermolysis bullosa hereditaria letalis had the characteristic electron microscopic lesions not only in the skin, but also in the gastro‐intestinal, genito‐urinary and respiratory tracts. Administration of dexamethasone to this patient resulted in a significant decrease in the blistering. Although the patient died, long term survival in this disease is not rare. We report that staining tissue specimens from patients with epidermolysis bullosa with fluorescein‐labelled bullous pemphigoid antibody is a reliable method for differentiating between junctional and dystrophic di

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05185.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYVery early skin lesions from four patients with pityriasis lichenoides chronica were examined by electron microscopy. Aggregates of tubular structures, which resembled those reported in endothelium in lupus erythematosus and are currently being observed in an increasing variety of conditions, were noticed in the epidermal cells of all patients. These cells also showed intracytoplasmic desmosomes, and isolated mitochondria and myelin‐like figures in intercellular spaces, in addition to the occurrence of vacuoles and lysosomes in the cytoplasm, dilatation of endoplasmic reticulum and alteration of mitochondria. Occasionally, epidermal cells were seen to be individually filled with fibrils. These ultrastructural findings seem to indicate that in pityriasis lichenoides chronica some injury to epidermal cells occurs at the early stage of pathological processes, as suggested by light microscope studie

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb05186.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY