摘要:

summaryA specific peptidoleukotriene receptor antagonist, Ro 23‐3544, was tested for its efficacy in modulating DNFB‐induced allergic and croton oil‐induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB‐induced ear swelling in a dose‐dependent fashion. Daily pre‐treatment of the ears for 1 week caused a more marked reduction of DNFB‐induced ear swelling during the first 48 h after elicitation. No reduction, but rather an increase in ear swelling was observed with croton oil‐induced dermatitis. These results indicate that peptidoleukotrienes play a role in the early stages of elicitation of murine allergic, but not irritant contact dermatitis and that a specific receptor antagonist can only partially reverse the effect of peptidoleukotrienes once the dermatitis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01743.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryThirty‐six patients with bullous pemphigoid (BP) and 15 with cicatricial pemphigoid (CP) were studied for evidence of mucosal involvement both clinically and by direct immunofluorescence. Twenty‐one patients with BP and all those with CP had lesions of the mucous membranes. Eighteen patients with BP and 14 patients with CP had involvement of the oral mucosa. Lesions of the eyes, nose, pharynx, vulva and urethra also occurred in both groups. The lesions tended to be more widespread in CP patients. Twenty‐one patients with BP and 14 with CP were examined by an ophthalmologist. Fine scarring of the tarsal conjunctiva was found in both groups, but also in elderly controls. However, symblepharon occurred in one patient with BP as well as in three patients with CP, but was not seen in a group of 20 controls. Direct immunofluorescence (IF) studies showed linear deposition of IgG or C3or both in the basement membrane zone of the skin, oral mucosa and conjunctival mucosa in both groups. The frequency of positive immunofluorescence was higher in the conjunctiva than in the lip mucosa or skin in both BP and CP patients. The significance of these findings and the relationship between BP and CP is disc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01744.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryImmunofluorescence showed that cultured skin fibroblasts from 15 out of 17 patients with Ehlers‐Danlos syndrome type IV retained abnormal amounts of type III collagen within the cytoplasm. This was not shown by fibroblasts from normal subjects or from patients with other inherited connective tissue diseases. The diagnosis of Ehlers‐Danlos syndrome type IV may be facilitated by this find

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01745.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryWe report the first observation of neutrophils in the dermal inflammatory infiltrate in human skin soon after moderate ultraviolet‐B (UVB) irradiation. Thus human UVB‐induced cutaneous inflammation, in this as in other respects, appears to resemble other human acute inflammatory responses to inj

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01746.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryHuman skin and mucous membranes were used to detect circulating auto‐antibodies by indirectimmunofluorescence in 20 patients with bullous pemphigoid and eight with cicatricial pemphigoid. The tissue substrate was used intact and after chemical separation through the basement membrane zone (BMZ) by incubation with i m NaCl. Chemically split skin and oral mucosa provided a more sensitive assay for demonstrating circulating anti BMZ antibodies. Use of a battery of substrates increased the number of positives in bullous pemphigoid from 30% detected on monkey oesophagus to 100% (tissue battery). In cicatricial pemphigoid there was an increase in the proportion of positive sera from 13% (monkey oesophagus) to 88% (tissue battery). In addition, a different class of antibody was frequently detected on split tissue substrate suggesting that new antigens are exposed by this procedur

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01747.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryA study of autoimmune related phenomena in 350 women with histologically confirmed lichen sclerosus et atrophicus revealed that 21.5% had one or more autoimmune related diseases, 21% had one or more first degree relatives with an autoimmune‐related disease, 42% had an autoantibody at a titre>1:20, and 59.5% had one or more of these autoimmune‐relateda phenomena. No statistically significant differences in the natural history of lichen sclerosus et atrophicus were demonstrated between those patients with autoimmune‐related phenomena and those wi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01748.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryNail infections caused byCandidaspecies are normally associated with chronic paronychia or chronic mucocutaneous candidiasis (CMCC). However, the role ofCandidain the pathogenesis of other primary nail dystrophies has been questioned in view of their response to antifungal therapy alone. In the present study of 86 patients with primary nail dystrophies from whichCandidawas isolated, three patterns of nail involvement were found. Nineteen patients, of whom 17 had CMCC, had total dystrophic onychomycosis of at least two nails. The second group consisted of 27 patients with paronychia and lateral onycholysis. In a further 40 patients, who did not have paronychia,Candidawas isolated from nails showing primary distal and lateral onycholysis. These changes were mainly seen in patients with peripheral vascular disease, particularly Raynaud's disease, or Cushing's syndrome. Nail biopsies from patients in the latter two groups confirmed the presence of yeasts and mycelium in the nail plate and 17 (46%) of those receiving antifungal therapy with ketoconazole or itraconazole showed complete clearance of the nail dystrophy. Good responses to therapy were seen more frequently in patients with peripheral vascular disease or Cushing's syndrome of whom 15 (72%) recovered; distal erosion of the nail plate, mycelium in the nail plate on biopsy or direct microscopy together with the isolation ofC. albicanswere all associated with good responses to antifungals. In addition to patients with CMCC or paronychia, therefore,Candidaappears to be a significant pathogen in some patients with primary onycholysis of the finger nails, particularly where there is underlying peripheral vascular disease or Cushing's syndrome.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01749.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryThe distribution of L1 antigen in four common skin tumours was examined immunohistochemically in 40 samples of formalin‐fixed routine biopsy material. Presence of L1 in the dermis depended on the extent and composition of the inflammatory infiltrate; L1 was found mainly in reactive histiocytes and neutrophils. Intense epidermal staining was seen adjacent to squamous cell carcinoma, basal cell carcinoma and malignant melanoma, but not adjacent to melanocytic naevi. In specimens of melanocytic naevi, L1 staining around pilosebaceous units was weak or absent. Around the three malignant types of lesion, epidermal L1 positivity faded distally‐thereby indicating the extent of the tumour. L1 was, in addition, expressed by the most highly differentiated cells in squamous cell carcinomas, whereas the other neoplasms were negative. Antibody to L1 may, thus, be a useful adjunct for distinction between various types of skin tumo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01750.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryWe have measured oestrogen and progesterone binding in specimens of histopathologically confirmed lentigo maligna (LM) lesions excised from five elderly white men, using a dextrancoated charcoal method. Oestrogen binding was observed in four of the five specimens, and progesterone binding in all five. Marginal normal skin showed only non‐specific binding for oestrogen and progesterone. The presence of steroid hormone receptors in LM suggests the possibility that hormone responsiveness may be relevant in the transformation of a lentigo maligna into malignant melanom

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01751.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

summaryWe describe seven patients, four female and three male, who developed intense pruritus on sun‐exposed skin without visible change. The clinical features resembled those of polymorphic light eruption (PLE) without rash. Four patients also occasionally developed typical PLE upon sun exposure, but sun‐induced pruritus alone occurred most frequently. No patient was taking any drug therapy. One patient developed similar pruritus following solar simulated irradiation, and one following PUVA therapy. All other laboratory investigations were negative. Treatment with low dose UVB phototherapy or PUVA therapy was effective. The condition, which we have called polymorphic light eruption sine eruptione (PLESE), appears to be a variant of PLE not previously repor

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb01752.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY