摘要:

AbstractIt is known that dichloroethylamines in which the two chloroethyl groups are bound to different N atoms at a given distance from each other retain their activity and considerably lower their toxicity. It was assumed that by controlling the distance between the two chloroethyl substituents to the polymer chain a product of analogous action could be obtained. Two possibilities of binding monochloroethylamine (MCA) to a polymer were investigated: (1) Copolymerization ofN‐vinyl pyrrolidone (VP) with monochloroethylamide of methacrylic acid (MCAMA). The constants of copolymerization of this pair:r1= 3.88 ± 0.31 andr2= 0.089 ± 0.017 were determined, as well as the mean length of the elementary link of the copolymer chain. It was found that at a ratio of VP:MCAMA = 1:3 a copolymer of statistically probable structure could be obtained in which the distance between two monochloroethylamine groups is the most appropriate: about 6 atoms. (2) A polymer‐analogous reaction of the copolymer of VP with maleic anhydride (MA) permitting the binding of MCA to the polymer chain by severing the MA ring. It was established that the reaction proceeded best in a medium of dimethylformamide at 80°C for 1 hr. Water‐soluble products characterized by their C1 content and ir spectra were obtained. These products showed a physiological

ISSN:0360-8905    

DOI:10.1002/polc.5070660103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractComplex formation in poly(vinylpyrrolidone)‐poly(itaconic acid monomethylester) and poly(vinylpyrrolidone)‐copolymer of maleic anhydride and monomethylitaconate systems has been investigated. It is shown that the interpolymer complexes are formed at interaction of macromolecular components. Data of conductometric, potentiometric, and viscometric titrations indicate that the molar composition of complexes is PVP:PMMI = 1:1 and PVP:MA/ MMI = 3:2. The complex particles are very compact with the intrinsic viscosity in water about 0.05‐0.10 dl/g not depending upon the molecular weight of polymer components. Complexes are destroyed both by inadequate organic solvent (30‐40 vol %) in mixed solvent water ‐dimethylsulfoxide, and by therm

ISSN:0360-8905    

DOI:10.1002/polc.5070660104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractPolymeric amine (Ia) was prepared by reacting a copolymer ofN‐(2‐hydroxypropyl) methacrylamide (HPMA) andN‐methacryloyl ρ‐aminocaproyl L‐leucinep‐nitrophenyl ester with 1,6‐diaminohexane in excess. The rate of reaction of (Ia) with reactive copolymers of HPMA andp‐nitrophenyl esters of methacryloylated amino acids was investigated. The results indicate that interpenetration of polymeric coils occurs in dimethylsulfoxide solution! .A study of the stability of cross‐links towards chymotrypsinin vitroshowed that in addition to steric factors, subsite interactions between substrate and chymotrypsin must also be borne in mind. An aimed synthesis of crosslinks allowing such interactions leads to an increase in the enzymatic degradability of th

ISSN:0360-8905    

DOI:10.1002/polc.5070660105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractResults are reported obtained by the ESR study of the mobility of spin labels bonded at the side‐chain ends of copolymers of the polymethacrylamide type. The correlation times, γ, characterizing the mobility of the spin label were determined by analyzing the EPR spectra of 1% methanolic solutions of copolymers. The log γ vs 1/Tdependences within the temperature interval 233‐313 K studied are linear and are characterized by the same activation energy,Ea= 3 kcal/mole (12.5 kJ/mole), for both types of the side chains. The mobility of the spin label bonded at the end of the side chain of the oligoglycine type is lower than that of the spin label bonded at the end of the equally long side chain of the methylene

ISSN:0360-8905    

DOI:10.1002/polc.5070660106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractPolymerizable derivatives of an antidiabeticN‐(4‐aminobenzenesulfonyl)‐N′‐butylurea were prepared. Hypoglycemic effects of sodium salts of the starting drug, the monomers, and their copolymers withN‐(2‐hydroxypropyl) methacrylamide were

ISSN:0360-8905    

DOI:10.1002/polc.5070660107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractPossibilities of polymer‐analogous labeling of soluble polymers with covalently bound fluorochrome in the side chain were investigated, usingN(2‐aminoethylcarbonyl)‐5(6)‐aminofluorescein (I), 4‐aminomethyl‐7‐hydroxycoumarine (II), and fluoresceinisothiocyanate (FITC) as labels. The properties of polyaspartamides labeled with I and FITC were compared with regard to their bond stability and intensity of

ISSN:0360-8905    

DOI:10.1002/polc.5070660108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA simple method has been suggested for the fractionation of polysuccinimide (PSI); the intrinsic viscosities of fractions were measured and the parameters of the Mark‐Houwink equation were determined. The possibilities of reactions of PSI with primary amines such as histamine, tyramine, tryptamine, mono‐BOC‐ethylenediamine, glycine nitroanilide, and ethanolamine were checked; the reaction rate constants and the effect of some catalysts were deter

ISSN:0360-8905    

DOI:10.1002/polc.5070660109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe molecular weight of polysuccinimide prepared by thermal polycondensation depends mostly on the reaction temperature. Antioxidants have no effect. Proteolytic enzymes do not degrade the main chain ofN‐substituted polyaspartamides tested. Bacteria are capable of utilizing about 4% of aspartic acid from the 2‐hydroxyethyl derivative. Side chains are sensitive to enzymes as in the previously studied polyolefinic polym

ISSN:0360-8905    

DOI:10.1002/polc.5070660110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractRat liver β‐D‐glucuronidase was inhibitedin vitroby a 1% concentration of dextran and polyvinylpyrrolidone at low enzyme concentrations. Pentosan polysulphate showed a similar effect, while three derivatives of the polyaspartamide were inactive. Microsomal aniline hydroxylase was inhibited by a 0.75% concentration of all polymers tested, the most active being the lysine derivative of polyaspartamide. No effect on the cytochrome P‐450 ‐ carbon monoxide reaction was detected. Microsomal aminopyrine demethylase activity was only slightly depressed by polymers, except for pentosan polysulphate, which showed stimulation. The carboxyethyl derivative of polyaspartamide inducedin vivothe activity ofN‐acetylt

ISSN:0360-8905    

DOI:10.1002/polc.5070660111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractGiven certain peculiarities of polysaccharides in comparison to synthetic polymers, a survey is made of the application of polysaccharides in the field of nutrition for calory‐reduced food, in pharmacy, and as auxiliary products in surgery, stressing to some extent recent results of the authors in cellulose and starch chemistry. In dealing with nutritional uses in calory‐reduced food, the problem of persorption of cellulose powders is discussed as well as properties and uses of recently developed starch products obtained by partial hydrolysis. In reviewing pharmaceutical uses of polysaccharides, we mention the active therapeutic effects of these substances, with detailed emphasis on the application of starch and cellulose products as carrier compounds. A survey of polysaccharide products as surgical auxiliaries is centered on their application as plasma expanders, as internal surgical dressings, and as external aids (glove powders). Finally, the need for further progress in polysaccharide chemistry is stressed as a prerequisite for finding and realizing new applications in restoring human hea

ISSN:0360-8905    

DOI:10.1002/polc.5070660112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY