ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03226.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTBetween 1980 and 1983 a total of 89 patients with infiltrating transitional cell carcinoma of the bladder were entered in a multi centre randomised controlled clinical trial with either misonidazole or placebo added to the first 40.00 Gy of radiotherapy. Depending on their referring clinican, patients then completed treatment with either further radiotherapy to a radical dose, or surgery four weeks later. All patients have been followed up for a minimum of three years, and no significant difference has been found in local control, survival, or pathological downstaging of the tumour. The neurotoxicity was considerable, with 43% of patients receiving misonidazole developing a peripheral neuropathy, starting five weeks on average after beginning treatment, and with a mean duration of 27 months. Eighty per cent of patients affected still had peripheral neuropathy at three years or their prior death. There is a suggestion that alcohol may predispose to the neuropathy. This study failed to show any benefit of misonidazole in tumour control and produced unacceptably high levels of toxicity.

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03227.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTImproved localisation of central nervous system (CNS) tumours resulting from newer diagnostic imaging techniques may allow the therapeutic irradiation of smaller volumes than currently practiced with the possibility of less normal tissue injury and/or the use of higher radiation doses. The influence of radiation dose and volume on the control rates for various types of CNS tumour and on the radiation tolerance of CNS tissue is imperfectly understood. Available data on these fundamental issues in the radiation treatment of CNS tumours is reviewed.

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03228.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTThe FIGO classification for the clinical staging of carcinoma of the cervix does not adequately express primary tumour extent or volume, and contains anomalies which probably lead to a wide variation in therapeutic results between centres (particularly in Stages II and III). A box diagram method of recording primary tumour extent is proposed and was applied to a retrospective study of 191 women aged 35 years and under with invasive carcinoma of the cervix. Patients who scored one or two boxes (Stages IB, IIA and IIB with unilateral parametrial infiltration) have a similar actuarial 5 years survival rate: 70% and 69% respectively. Those with 3 boxes (Stage IIA and B, bilateral Stage IIB and unilateral IIIB) and 4 boxes or more (Stages IIA and B, bilateral IIIB) involved had a substantially worse survival: 44% and 22% respectively. No patient, with more than five boxes involved was cured. The further study of this system, its potential in clinical research, and as part of a possible revised staging system are discussed.

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03229.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03230.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTThere are currently many computed tomographic units with differing performance capabilities, resulting in confusion over protocols for contrast medium usage. Additionally, the development of the safer but more expensive low osmolar contrast agents has increased interest in evolving clearer indications for contrast medium usage in C.T. scanning.Rationales for the use of intravenous agents in C.T. scanning are proposed. These include the labelling of normal structures for anatomic clarification, the assessment of perfusion, the characterisation of a specific lesion, CT Angiography, demonstration of defects in the blood brain barrier and the phenomenon of neovascularity. The logical use of contrast agents should involve the deliberate invocation of one or more of these mechanisms coupled with the appropriate technique of administration.

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03231.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03232.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTThe planning and installation of a Superconductive Magnetic Resonance Imaging (M.R.I.) installation is described at the Royal Adelaide Hospital, Adelaide, South Australia. Tender specification, assessment of offers via criteria weighted analysis of technical and economic factors and the final recommendation for a 1.0 Tesla unit are discussed. Building and installation considerations are noted including fringe field effects, magnetic shielding, radiofrequency shielding, cryogens, metallic screening and specific considerations in the Magnet room.

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03233.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTIn the evaluation of tumours of the cerebellopontine angle MRI has a sensitivity and a specificity slightly greater than that of CT. At present it does not appear justified to displace CT as the standard means of investigation of a CPA tumour. The role of MRI is analagous to that of air‐C

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03234.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT50 patients underwent myelography on an outpatient basis; the incidence and severity of side effects were compared, in a prospective study, with 180 inpatient examinations over the same period. In addition, in the initial 200 myelograms (36 outpatient and 164 inpatient) iohexol and iopamidol were compared in a double blind trial.Headache was the most common side effect in both patient groups, recorded in 50% of outpatients and 25% of inpatients. Other side effects were of comparable incidence. 84% of outpatients undergoing myelography found it “acceptable”, and did not consider a night in hospital necessary after the procedure. No difference in side effects was demonstrated between the two contrast media.This pilot study suggests that outpatient myelography is practical and safe, with considerable cost saving implicati

ISSN:0004-8461    

DOI:10.1111/j.1440-1673.1989.tb03235.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY