摘要:

Summary.By paraneural injection of Trypanblue the presence of a blood‐brain‐barrier has been demonstrated in some common freshwater teleo

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01455.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Zusammenfassung.1. Mischungen von mehr oder weniger hochmolekularen Eiweissabbauprodukten werden von Gewebezellen unter Wachstumserscheinungen ausgenutzt. Die Produkte derhomologen Eiweissesind wirksamer als die derheterologen.2. Die mit Erepsin weiter abgebautenhomologen Eiweissesind weniger wirksam als die mit Pepsin abgebauten. Umgekehrt verhalten sich dieheterologenmit Erepsin abgebauten Eiweisse, indem sie im allgemeinen relativ wirksamer als die entsprechenden mit Pepsin abgebauten sind.3. Der Artunterschied der Eiweisse macht sich auch in der Wirkung der Polypeptide deutlich bemerkbar. Dies steht wahrscheinlich mit Verschiedenheiten im Bauplan der entsprechenden Peptide in Verbindung, d. h. damit, wie sich die einzelnen Aminosäuren in der Peptidkette in bestimmten Abständen periodisch wiederholen.4. Mit Hilfe der höheren Eiweisspaltprodukte verschiedener Eiweisse lassen sich Gewebezelltypen innerhalb derselben Tierart unterscheid

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01456.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01457.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.Phosphate esters are accumulated in the intact livers of rats and rabbits during assimilation of hexoses and glycerol, which latter was examined on rats only.During absorption of fructose the fructose ester accumulated showed qualities similar to those offructose‐1‐phosphoric acid; no fructose‐6‐phosphoric acid was accumulated. The amounts of fructosephosphoric acid accumulated in the liver and in the intestinal mucosa of the same rabbit seem to be equal with regard to quantity and synthetising intensity. The amounts of ester may be calculated at about 100 mgs of the ester per 100 g of liver tissue; this amount was rebuilt almost completely within 4 minutes as shown in an experiment with radioactive phosphorus.The phosphate esters accumulated in livers of rats during absorption of glucose and galactose are probably to some extent aldose‐esters i. e. glucose‐6‐phosphoric acid (and galactose‐6‐phosphoric acid?). Some of the esters accumulated during absorption of glucose and galactose in the livers of rats and rabbits were very sensitive to acid hydrolysis and relatively resistant to hydrolysis with alkali; the possibility exists that these esters are glucose‐1‐ and galactose‐1‐esters respectively.During absorption of glycerol an amount of glycerol representing about 100 mgs glycerol per 100 g liver tissue of rats was esterified; as phosphoglyceric acid and triosephosphoric acid could be excluded, the ester in believed to be (α‐ ?)‐glycerophosphoric acid.No accumulation of fructose‐1‐phosphoric acid was observed in the kidneys or muscular tissue of rabbits during assimilation of fructose, but the contents of fructose‐6‐ester of the preexisti

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01458.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.When reticulocytes in vitro are suspended in physiological salt water and incubated at 40° the reticulocytes disappear only very slowly.The rate of disappearance can be accelerated considerably by adding liver extract to the salt solution or when the reticulocytes are suspended in plasma.The youngest and most unripe types disappear first. The disappearance thus must be due to a maturation of the reticulocytes into “adult” erythrocytes and this process must be accelerated by some unknown ripening substances found in plasma and liver extract.The ripening process follows the monomolecular equation.The monomolecular constant is proportional to the concentration of ripening substances in the suspending solution.The monomolecular constant increases with increasing temperature.When reticulocytes from the same animal are used, the monomolecular constant found at different times is the same if the same concentration of ripening substances is used in the experiments.The monomolecular constant can vary ± 25 per cent when reticulocytes from different animals are used. The proportion between two tested solutions is, however, always the same, independent of the animals

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01459.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.The reticulocyte ripening principle in liver extracts consists of a thermolabile fraction which can be absorbed by floridin and a thermostable fraction which cannot be absorbed by floridin.The latter fraction has only little effect by itself but activates the effect of the thermostable component.The thermostable activating component is identical with 1‐tyrosine which is found in the liver extract

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01460.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.None of the 13 most common amino acids show any activating effect on the reticulocyte ripening principle. Only tyrosine has this effect. Investigations on some tyrosine derivatives show that the phenol group is essential to the effect of tyrosine. The phenol group must be in para position to the side chain. The amino group can be replaced by an oxo‐, an oxy‐. or a methyl‐amino group. Minor changes in the molecule not affecting the OH group give only some reduction in the act

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01461.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.Carbon‐monoxide‐hemoglobin methods of determination that deal with strongly diluted blood must give too low values owing to the fact that carbon‐monoxide‐hemoglobin dissociates on dilution. A simple method, sufficiently accurate for clinical use, has been worked out from which these sources of error have been eliminated.The determination is easy to carry out and takes only a few minutes. An important advantage of the method is that it enables determination on a micro‐scale, so that blood may be taken from the tip of the finger. Samples can be sent in capillary tubes, as for instance is done in the case of blood‐tests for alcohol according to Widma

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01462.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.1. A unit for antithrombin is defined as the amount of antithrombic substance which inactivates one unit of thrombin.2. A method for the quantitative measurement of antithrombin in plasma and serum is described. Its relation to earlier unsatisfactory methods is discussed.3. The normal antithrombin of ox plasma is investigated and its properties found in accordance with those described by other authors.4. The amount of normal antithrombin in plasma and serum generally ranges from 100 to 150 antithrombin units per ml.Thanks are due to “Danmarks tekniske Højskoles Fond for teknisk Kemi” and to “Løvens kemiske Fabrik”, Copenhagen, for grants in aid of

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01463.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.The milk prothrombin level was studied in cows and human beings. In the months before and directly after calving one can demonstrate considerable amounts of prothrombin in cow's milk. The woman colostrum also contains prothrombin but only in small amounts. At other times in the lactation period the cow's milk and human milk contain only negligible amounts of prothrombin.The prothrombin content in the cow's colostrum is of no importance to the increase of the prothrombin in the blood of the new‐born cal

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01464.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY