摘要:

Abstract:Human leukocyte antigen (HLA) class II allogenotyping has been applied to investigate the polymorphism of the DRB, DQB1, DQB2, DQA1, and DQA2 genes in Aborigines from the East Coast of Australia and in Melanesians from the Papua New Guinea North‐East Coast and Highlands. Three new DR/DQ arrangements were observed, DRw14/DQB1‐2b/DQA1‐1a and DRw5Nauru/DQB1‐3a/DQA1‐2 (in Australian Aborigines), and DR wSNauru/DQB1‐1a/DQA1‐1b (in Madang). DQA2 and DQB2 allogenotyping with TaqI and PstI digested genomic DNA revealed little polymorphism among the Papua New Guineans, with DQA2‐Xa1 and DQB2‐Xb1 the most common alleles in all the groups. However, the presence of DQA2‐Xa2 in Papuans and Australian Aborigines reflects the degree of admixture with Caucasoids while the DQA2‐Xa4 allele in Madang is probably a marke

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02147.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:We have investigated the HLA‐class I and class II polymorphism in a population of 83 Romanians using conventional serology together with PCR amplification and oligonucleotide typing of HLA‐class II genes. Romanians show a higher frequency of HLA‐A11, B13, B18, B37, B39, B51 and DR2 than other European populations. HLA‐DRB1*1501 and 1601 account for the high frequency of the serologic specificity DR2. In Romanians, HLA‐DR2 is in linkage disequilibrium with HLA‐B18 and HLA‐Bw52 rather than with HLA‐B7 as is the case in other Europeans. Unexpected HLA‐DR2 haplotypes include HLA‐DRB1*1502, DQA1*0102, DQB1*0601; HLA‐DRB1*1602, DQA1*0102, DQB1*0502. Other unusual haplotypes include HLA‐DRB1*0405, DQA1*03, DQB1*0302; HLA‐DRB1*1305, DQA1*0103, DQB1*0603; and HLA‐DRB1*1405, DQA1*0101, DQB1*05032. Analysis of the genetic distance between Romanians and other Europeans who have been studied serologically are consistent with the hypothesis that Romanians descend from Roman ancestors who colonized Dacia between the 1st centu

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02148.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:HLA‐DP polymorphism was examined in 71 rheumatoid arthritis patients and 148 controls, using dot‐blot analysis with 14 synthetic oligonucleotide probes specific for the variable region of the DPB1 second exon. The DPB1 0401 allele was found to be significantly more frequent in RA patients than in controls (77.46% vs 55.40%, p<0.002, pc<0.03, relative risk value:2.74). An association between DPB1 0401 and seropositivity for rhumatoid factors was also observed: 44 of the 55 seropositive RA patients were DPB1 0401 (p<0.001). Analyzing the HLA DPB1 alleles frequencies in 57 HLA‐DR‐typed RA patients did not show any linkage between the DPB1 0401 and the DR4 specificities. Furthermore, the DPB1 0401 homozygous frequency was increased in DR4‐negative RA patients. Our findings suggest an independent role of the DPB1 0401 allele in the genetic susceptibil

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02149.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:I. Levin, B. Klein, S. Segal, A. Eyal, J. Gopas, J. Kaneti, M. Saadon, O. Kuperman. Expression of HLA class I‐encoded cell surface antigens in transitional cell carcinoma of the urinary bladde

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02150.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02151.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02152.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02153.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:J. D. Bignon, M. L. Cheneau, P. Herry, F. Bonneville, A. Cesbron, J. Y. Muller. Strong linkage disequilibrium of HLA DPw11 with the HLA B44‐DR7‐DQw2 extended haplotype. Tissue Antigens 1992: 39: 35

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02154.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:Oligotyping for HLA‐DRB1, DQA1 and DQB1 specificities has been performed on PCR‐amplified DKA from 55 Italian celiac children, living in Rome. and 50 blood donors. 52.6% of CD patients were DR3;DQ A1 *0501; DQB 1 *0201 ‐positive versus 14% of controls (RR = 6.85) and 34.5% were DR5,7;DQA1*0501;DQB1*0201‐positive versus 2% of controls (RR = 25.86). 7 patients (12.7%) were negative for the DQA1 *0501/B1 *0201 dimer: 3 of them were DR4 (5.4%) and the others typed as DR1,5; 1,7: 5,7 and w6,7. No patient was negative for both DQA1*0501 and DQB1*0201

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02155.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1992.tb02156.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY