摘要:

The HL–A groups of 138 Kel Diniq Twaregs were determined by the platelet complement fixation microtechnique. Their HL–A characteristics, compared to those of Caucasoid populations, are: decrease in HL–A2, 9, W17 and W15; increase in W28, W32, HL–A7, W5, W10 and second locus blank; absence of Da25 (W30 + W31), HL–A13, W15, W18, W27. This genetic structure is in accordance with the isolated condition of this population.The most frequent haplotypes are: W28,HL–A7, common to both the Kel Diniq and the Kel Kummer Twaregs previously studied; W32,W10 and HL–A3, HL–A5, Kel Diniq only.These two populations are both isolates, with a common origin in the seventeenth century, but separated as from that date. Genealogical studies have enabled the haplotype W28,HL–A7 to be attributed to the two brothers who founded the populations in the seventeenth century.A comparison of these two populations constitutes a model for the study of genetic drift and t

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00519.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00520.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Plasma samples from 28 renal allograft recipients were studied for the presence of alloanti‐bodies blocking MLC response. MLC blocking antibodies were found in plasma samples obtained from 19 recipients, six with rejected allograft and 13 with long‐term surviving transplant. In many instances, these antibodies were found in the absence of detectable lym‐phocytotoxic antibodies. The MLC blocking activity resides in IgG fractions of plasma samples and was decreased only after absorption with lymphocytes, no effect on blocking was observed by absorption with platelets and fibrob

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00521.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The second series antigen W27 has been found to have an increased frequency in ankylosing spondylitis (82 % of 17 patients) and juvenile rheumatoid arthritis (Still's disease) (29 % of 24 patients). Three family studies are presented, including one in which the antigen W27 occurs both in the absence and the presence of ankylosing spondylitis. It is suggested that this family illustrates that the relationship between W27 and sacro‐iliitis is affected by non‐HL–A genes. The development of clinical disease depends upon the coincidence of several factors in one individual, some of which are genetically controlled by two or more loci which are not necessarily l

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00522.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

A comparison of immunogenic strength among 23 HL–A antigens was made by studying HL–A antibodies formed in primiparous women. In this setting of single pregnancies, each one of the incompatible fetal antigens would have an equal opportunity (one gestational period) to sensitize the mother. Three hundred pairs of primiparous women and newborns were HL–A typed and the serum of each mother was tested for antibody activity against the child's lymphocytes.The test was positive in 24 instances; 19 sera were reactive with only one antigen of paternal origin, one serum was reactive with both antigens, and in four instances the children's incompatible antigens were not identified. When the frequencies of different antibody specificities were statistically analysed, HL–A5 and W14 were found to be distinctly more immunogenic than the other a

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00523.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

HL–A phenotypes were determined in 60 patients with primary thyrotoxicosis and in 60 age‐sex matched controls living in the same region in order to establish the frequencies of ten HL–A antigens in the two populations. HL–Al was present in 28 patients and 18 controls (X2 = 2.86, P>0.05). HL–A13 was present in eight patients and only one control (X2 = 4.32, 0.05>P>0.025). These findings suggest that HL–A phenotypes may be of value in studies on the aetiology of primary thyrotoxicosis. The statistical significance of these results is discussed as these findings may be due to chance

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00524.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

One out of four rabbits injected with partially purified soluble HL–A antigen from serum produced cytotoxic antibodies to human lymphocytes. These antibodies appear to be directed tc the specificity W24 as determined by correlation studies with HL–A alloantisera and by absorption‐inhibition experiments with human platelets and with serum soluble HL–A antigens.In the sera from the other three immunized rabbits, no antibodies to human lymphoid cells could be detected by the cytotoxic test, blocking of T cell rosette formation, stimulation of DNA synthesis and inhibition of mixed lymphocyte r

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00525.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00526.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Studies were carried out on the distribution of HL–A antigens in 33 patients with Burkitt lymphoma from several tribal groups in Kenya. The frequency of distribution of the HL–A antigens was not significantly different in these patients from that in a selected control population. Difficulty was experienced in the precise identification of some HL–A antigen in Africans using a Caucasoid serum panel, in particular those associated wlth HL–A7 and to a lesser extent, the “W19

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00527.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Thirty‐one Burkitt's patients and forty‐eight matched controls from Uganda were HL–A typed to investigate possible antigen frequency differences which could suggest association of an HL–A antigen with disease susceptibility. Cells were shipped in tissue culture medium from Uganda to Oxford where they were HL–A typed using sera from the Fifth International Histocompatibility Workshop in the cytotoxic fluorochromatic assay. No significant frequency differences between patients and controls w

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00528.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY