摘要:

The lymphocytotoxic activity of 144 rhesus alloantisera was evaluated in 112 unrelated rhesus monkeys and 33 pedigreed rhesus families. This study was conducted using a standard complement‐dependent microcytotoxicity assay. A computer‐assisted X2analysis of the reactivity of these sera in the unrelated monkeys generated 23 groups of highly correlated antisera. The two‐locus model of the mammalian major histocompatibility complex was assumed for the monkey, and genetic criteria for RhLA antigens were determined prior to study. Seventeen groups of antisera met these predetermined criteria. Six were products of the B locus and 11 were products of the A locus. Sixteen were similar or identical to antigens previously described by us or by Balner and coworkers in The Netherlands. One has not been previously described. A frequency analysis indicated that these 17 antigens represented approximately 74% of the total expression of these two

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01217.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The appearance of activated lymphocytes and antibodies in the circulation of rats was monitored following allogeneic kidney, skin, or combined skin‐spleen transplants. Lymphocyte activation was measured by3H‐thymidine incorporation, and antibody by a hemolytic assay. These assays have been developed so that small samples of blood could be used, thus maintaining recipient survival and allowing for daily correlation between the response observed and the fate of the graft. These responses were detected after allogeneic transplantation in two recipient strains, but not following isogeneic renal or skin transplantation in either strain. The relative levels, time of onset and persistence of lymphocyte proliferation and of hemolytic antibody were found to differ substantially for the three different kinds of allografts. In general, these studies have demonstrated the validity of using the lymphocyte proliferative and humoral responses together as indicators of a current immune response against allogeneic renal transpla

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01218.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Six functionally HLA‐D homozygous typing cells were identified by a restricted investigation into the Hungarian inbred population of Ivad. These putative HLA‐D homozygous typing cells were then tested against a highly selected Scandinavian population sample of 60 individuals previously typed by histocompatibility reference reagents. Three different HLA‐D specificities could thus be identified: one closely matching HLA‐Dw5, another resembling the Oslo LDoH specificity, while the last seems to be unique.Only one of the typing cells thus ascertained were HLA‐B homozygous and were selected on the basis of the Ivád family structure and not on the basis of serological

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01219.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Available lymphocytotoxic antisera permitted the clear partition of the Bw21 antigen into two distinct components, Bw21.1 and Bw21.2. Bw21.1 is associated with W4 and is approximately twofold more frequent than the W6‐associated Bw21.2. Cells of either Bw21 subtype were capable of absorbing specific anti‐Bw21.1, anti‐Bw21,2, and anti‐Bw21 (21.1 + 21.2) antibodies. Further, an F(ab')2fragment prepared from an anti‐Bw21.1 serum blocked cytotoxicity of anti‐Bw21.1, anti‐Bw21.2 and anti‐Bw21 (21.1+21.2) sera. Based on the crossreactivity (by absorption) and blocking data, a model is proposed relating the Bw21 subtypes and the W4

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01220.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Antibody production to the liver‐specific F antigen was tested in recombinant strains of mice of different H‐2 types to determine whether a histocompatibility‐linked immune response (Ir) gene controlled responsiveness to this antigen. Responsiveness was found to be controlled by an Ir gene located in the K end (K and/or I‐A subregions) of the H‐

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01221.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Balkan endemic nephropathy, a fatal family disease with unknown aetiology and pathogenesis is typical for three neighbouring regions in Bulgaria, Yugoslavia and Rumania. HLA typing of 180 patients from the endemic area in Bulgaria was done and the antigen frequencies were compared with 1264 healthy controls. An increased frequency (P<0.001) of the antigen HLA‐B18 in the patients was demonstrate

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01222.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The comparative study of a control group made up of 340 healthy subjects, a group of 100 unrelated patients, all showing signs of type II hyperlipoproteinemia and a family of 15 members covering three successive generations, brings to light the highly significant increase of the recurrence of HLA Bw17 antigen and the increase in frequency of HLA Bw35 antigen.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01223.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01224.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A total of 60 leprosy patients, 28 of lepromatous and 32 of tuberculoid form, and 70 active tuberculosis patients was compared with a control of 184 for 34 HLA specificities. The most interesting finding was an increased frequency (10.0%) for HLA‐B8 (correctedP= 0.062, relative risk = 20.3) in the leprosy patients as compared with the control group, despite the fact that the frequency of HLA‐B8 was extremely low in Japanese. Furthermore, all leprosy patients with B8 had leprous member(s) in their fam

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01225.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01226.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY