摘要:

H‐2 alloantisera contain Ia antibodies whose detection is obscured by the presence of serodominant K, D specificities. A method is described whereby Ia antisera can be prepared by absorbing conventional H‐2 sera with donor‐strain erythrocytes. The analysis of such absorbed antisera has led to the identification of the new specificity Ia. 16, and the redefinition of the specificities H‐2.34 and H‐2.46 as complex Ia specificities which map in the I‐A region of the H‐2 complex. A number of other so‐called H‐2 specificities also appear to have I

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01023.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A family with high prevalence of ankylosing spondylitis (A.S.) was investigated for the presence of HL‐A27. In this family, classical A.S. occurred in five subjects and possible A.S. in two out of 64 members examined. In all seven cases, HL‐A27 was present. The study of the segregation of A.S. and HL‐A27 in this kindred demonstrates that more than one gene is responsible for the expression of A.S., that the homozygous state for the HL‐A27 gene may lead to the occurrence of A.S., and that possibly a simple genetic explanation accounts for the simultaneous transmission of HL‐A2

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01024.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A panel of over 100 individuals was tested against several 4a and 4b antisera. A 4a/4b type was assigned to each individual on the basis of overall reactions with each group of sera. It was felt that because 4a and 4b antisera rarely give identical reaction patterns the use of several sera in each group gave a better definition of the specificities.The relationship between each second locus HL‐A specificity and 4a or 4b was assessed. Most of the “narrower” antigens showed complete inclusion within one group but there were some anomalies. Associations of these specificities were analysed further by absorption experiments.4a and 4b antisera were able to define differences in some second locus specificities which were not picked up by the narrower antisera. It seems likely that 4a and 4b represent a separate public site on the HL‐A gene product which is multifactorial. For a full description of the antigens all factors should be stated as there is not an invariant association between com

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01025.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01026.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The frequency of HL‐A8 in myasthenia gravis is markedly increased in women (60–80%) but not in men. The MLC determinant, LD–8a, is frequently associated with HL–A8. Of the 37 female MS patients, 15 were LD–8a positive (41%), whereas of the males only one of seven was LD–8a positive. The frequency of HL–A8 was 68% in women and 29% in men with the disease. We therefore conclude that the gene which is responsible for the increased susceptibility to myasthenia gravis in women and which is present in the MHS region, is more closely linked to the SD–2 than to

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01027.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

HL‐A phenotype frequencies were studied in 36 patients with Sjögren's syndrome and compared with those of 350 healthy individuals from the same geographical area. Patients suffering from Sjögren's syndrome had a significantly higher frequency of HL‐A8 (Pcorrected<0.01). The relative risk of developing Sjögren's syndrome is 3.96 for HL‐A8 positive ind

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01028.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01029.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01030.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01031.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb01032.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY