摘要:

HLA‐A, B and C antigens tested in 97 patients treated for congenital hypothyroidism, and in members of their families, are compared with normal frequencies from 635 controls. After adjustment for the number of tests, there remains in the patients only a negative association with A11, with a relative risk of 190, and no significant association in the relatives. Patients show no excess homozygosity and no deviations in haplotype frequency. Congenital hypothyroidism thus appears to show a different relationship with HLA from other thyroid disorder

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01409.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

In fifty‐seven patients with alcoholic cirrhosis the frequency of HLA—DR2 was found to be 47.4%, in contrast to 26.1% in 1 19 normal subjects and 14.0% in 43 cases of autoimmune‐type chronic active hepatitis (CAH). The frequencies of HLA—DR3 in the three respective groups also differed, being 24.6%, 31.9% and 74.4%. The greatly differing HLA—DR profiles in alcoholic cirrhosis and CAH point to immunogenetic differences in predisposition to these two liver

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01410.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The expression of HLA—A and—B antigens on peripheral blood lymphocytes and blood platelets was measured using monoclonal antibodies in a semi‐quantitative ELISA technique. Reactively of monoclonal anti‐HLA—A2 and anti‐HLA—B7, with lymphocytes as well as platelets, was in agreement with the presence of these antigens as detected by conventional HLA typing of lymphocytes. When the actual amount of HLA antigens was measured, a gene‐dose effect was seen: cells from HLA—B7‐homozygous individuals bound more monoclonal anti‐HLA—B7 antibodies compared to their HLA—B7‐heterozygous siblings. At the same time, cells of different donors showed only very small differences in binding of monoclonal antibody against an HLA‐“backbone” determinant. Relative to total HLA‐A,—B and—C expression, the amounts of HLA—A2 on lymphocytes and platelets were similar. On the other hand, the expression of HLA—B7 on platelets was diminished compa

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01411.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Serum levels of immunoglobulins (Ig) IgA, IgG and IgM were measured in 96 HLA—typed patients with Graves'disease and an equal number of sex and age matched controls.Patients showed significantly increased serum immunoglobulin levels compared to controls. HLA DR3‐positive patients had larger elevations of IgG concentration than their HLA—DR3‐negative counterparts. Variation in serum immunoglobulin levels was not associated with sex, treatment or ophthalmopathy. It is suggested that the hypergammaglobulinemia of Graves'disease is related to defective suppressor cells triggered by Ig or Ig‐linked genes. HLA‐related gene(s) must, in addition, be involved to account for hypergammaglobulinemia G in the HLA—DR3‐positive sub

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01412.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The frequency of HLA—Dw1—8 and DH was determined in 389 unrelated healthy Danes and in 257 kidney patients. All individuals were HLA—A, B, C typed, 168 of the normal individuals and all kidney patients were typed for HLA‐DR.The frequency of Dw1—8 in the normal material and kidney patient material was quite similar except for Dw6, which showed an increased frequency among the kidney patients, but as the patients are not prospectively ascertained, the significance of this finding is unclear. The frequency of the blank allele is 0.19 which is comparable to other Seandinavian materials but much lower than that seen in the joint report of the 8th International Histocompatibility Workshop. The D frequencies correlate quite well with the HLA—DR frequencies, the biggest discrepancy between D and DR exists for D/DR4, where DR4 is much “broader”. The DR4 positives can be divided into the Dw4 positives, strongly associated with B15 and the Dw4 negatives, not associated with B15 but with B40. Primed lymphocyte typing in some cases followed HLA—DR, in other cases HLA—D assignment. For HLA—D/DR2 the DR assignment also seemed to be broader, the DR2 positive, Dw2 negative group not being associated with B7, but possibly with B5.In the assignment of HLA—D determinants, “false negatives” have caused problems in many materials, but the inclusion of a number of known control responders in our experiments has made it possible to increase the accuracy of assignment by adjusting the cut‐off level for typing responses according t

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01413.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Class II molecules of 17 B10.W lines (i.e., congenic lines carryingH‐2haplotypes of wild mice on C57BL/10Sn or B10 strain background) were analyzed by immunochemical methods of precipitation and co‐precipitation. The analysis included typing for previously defined antigenic determinants, as well as determinants defined by new reagents, and mapping of the genes controlling these determinants. Using this approach, an Ia chart of the typed B10.W lines could be constructed. Genes controlling determinants Ia.38, 102, 103, 104, 105, and 106 were mapped intoA(AβorAα) locus; genes controlling determinants Ia.41, 107, 108, and 109 were mapped in theE(EβorEα) locus. The study suggests that the polymorphism of at least some of the class II loci could be as high as that of the class

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01414.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A Black American family of four generations with 29 members was studied. Six family members spanning two generations were affected with myotonic dystrophy. HLA A, B, C and DR antigen specificities were determined for each family member using local typing trays. Twelve HLA haplotypes were identified in the family. No significant association was found between the disease and any HLA antigenic type or haplotype. This finding suggests that the involvement of the major histocompatibility complex in the etiology of myotonic dystrophy is unlikely.The cellular responses of twenty‐eight family members and 20 unrelated Black Americans to phytohemagglutinin (PHA), Concanavalin A (Con A) and pokeweed mitogen (PWM), each in three concentrations, were tested with mononuclear cells prepared from peripheral blood. There was a significant difference in responses of the affected family members as compared to the unaffected family members and the unrelated Black Americans. The PHA and PWM responses of the unaffected family members are not significantly different from those of the unrelated Black American controls; however, the Con A responses of the unaffected family members are significantly higher than those of the control group at the lowest Con A dosage. The possible systemic defects of cytoskeletal structures of the affected family members are discusse

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01415.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Certain characteristics of 38 homozygous typing cells (TC's) of rhesus monkeys were determined. These TC's define ten RhLA—D locus specificities. Eight of them are associated with established RhLA—DR antigens. Two other groups of typing cells, D9 and D10, were previously considered to be associated with “blank” antigens of the DR series; they now appear to be associated with B‐cell antigens which are also likely to be controlled by the DR locus. No influence of RhLA—A or B antigens of MLC reactivity was observed. It was shown, however, that products of at least one locus other than D/DR is responsible for MLC stimulation. Whether those MLC antigens are associated with serologically identifiable B‐cell antigens which are not controlled by the DR locus, is

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01416.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A population of 94 unrelated rhesus monkeys was typed for MLC antigens using 38 homozygous typing cells which define ten RhLA—D specificities. A genetic analysis showed that the ten D specificities are alleles of a single locus, the gene frequencies of which are in Hardy‐Weinberg equilibrium. The association between the cellularly defined D and the serologically defined DR antigens in the population was usually high, confirming the close relationship between D and DR antigens. Two new associations were found, i.e. between the D‐locus antigens 9 and 10 and the serologically defined B‐cell antigens 109 and 101, respectively. This observation confirms prior speculations that the latter two antigens may belong to the DR

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01417.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

C2 hemolytic activity has been measured in serum and C.S.F. of 67 multiple sclerosis (M.S.) patients classified in three evolutionary groups according to the index of progression of the disease and tested in HLA‐A, B, C, DR and Bf. The median level of serum C2 is normal whether it is of the evolution or the HLA type. The average level of C.S.F. C2 is the same in the evolutionary groups and is low in patients bearing B18 allele or B18, DR2 haplotype. It seems that the median level of C.S.F. C2 is linked to the HLA types associated to the susceptibility gene(s) of the diseas

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01418.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY