摘要:

Five hundred patients with cancer were tested for 32 HLA antigens and the antigen frequencies compared with those of 500 control subjects matched for race, sex and age. Although the overall frequencies showed no significant differences, detailed analysis with regard to site of cancer, age and the number of antigens detected at each locus revealed significant differences. Phenotype tables and haplotype frequencies have been included.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01072.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The increased frequency of HLA‐B8 in Sjögren's syndrome was recently reported independently by Gershwin et al. (1975) and Iványi et al. (1976).The association of HLA‐B8 antigen with other diseases, characterized generally by impaired immunologic reactivity, has been shown (see Svejgaard et al. 1975, Dausset&Hors 1975), and in some of these diseases MLC typing has revealed the strong association also with the Dw3 determinant. The degree of association with each of the two, B8 and Dw3, varied between different diseases, in some of them having been reported to be higher for antigen B8 (Möller et al. 1976) and in the others for the determinant Dw3 (Thomsen et al. 1975, 1976). In some of the diseases, the association was found to be equally strong for both determinants (Solheim et al. 1976, Thorsby et al. 1975).In this communication, we describe the typing of HLA—Dw3 in 29 patients with Sjögren's syndrome (Ss). They represent part of the experimental group reported in a previous study (Iványi et

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01073.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Lymphoblastoid cell lines of homozygous typing cells were used as the sensitizing cells in MLC to prepare PLT cells. Results obtained using such cells against a panel of restimulating cells were compared to those obtained using regular PLT cells in which priming had been accomplished with normal peripheral blood lymphocytes. It appears that lymphoblastoid cell lines can be used for this purpose; the advantages of such an approach are given.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01074.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Five new serologically defined (SD) tissue antigens of rhesus monkeys are described. Results of a population study and a segregation analysis in families were consistent with their control by the major histocompatibility complex (MHC), as alleles of the two previously established SD loci of RhL‐A. The number of identifiable SD specificities of the rhesus monkeys'MHC is now twenty‐five, thirteen controlled by the SD1locus and twelve by SD2. The recombination frequency between SD1and SD2is estimated to be 0.3%. No evidence of a third SD series, as analogue of the human HLA—C locus, has yet been

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01075.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Where it is possible to ascertain a number of families each having two or more siblings with a particular disease, data from such families can be used to test for the presence or otherwise of important genes in the HLA chromosomal region causing susceptibility to the disease. The method for analyzing such data is detailed.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01076.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Thirty‐eight patients with severe chronic active liver disease (CALD) were found to have a significantly higher frequency of HLA‐Dw3 (68%) than 91 healthy controls (24%) (P<0.0001). The association of CALD was statistically significantly stronger with the D locus than with the B locus of HLA. The response to treatment was significantly worse in patients with HLA‐Dw3 than in patients who lacked this an

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01077.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01078.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01079.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Reported associations of HLA antigens with MS have varied considerably. In this study we have examined 330 clinically definite MS patients from the United States. The frequency of DW2 (52%) was highly statistically significant in MS patients as compared to controls (p<0.00001). Neither A3 nor B7 was significantly increased in MS; however, the joint occurrences of A3‐DW2 (20% vs 7%, p<0.001) and B7‐DW2 (30% vs 13%, p<0.0002) are highly associated with

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01080.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

In the study of disease correlations with specific antigens, the current expression for “relative risks” is computationally convenient. However, a more exact expression has been devised which is also more easily interpretable as the relative probability of contracting a disease for individuals carrying a specific antigen as compared to the probability for those not carrying that anti

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01081.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY