摘要:

SUMMARYA multicentre clinical trial has been conducted to assess the efficacy and safety of tretinoin 0.05% cream (Retin‐A®) in the treatment of photodamaged Australian skin. Subjects with cutaneous facial photodamage were randomised to treatment with tretinoin (62) or vehicle (63) cream. After an initial two week run‐in, all subjects applied the cream to the face, neck and left forearm/hand, once nightly for 24 weeks. Changes in clinical signs of photodamage and parameters of cutaneous irritation were assessed by investigators using a 7 point scale, whilst changes in signs of photodamage were rated by subjects using a 5 point scale. Changes in skin biopsies and silicone skin surface replicas were also assessed. Significant improvements in skin wrinkles, mottled hyperpigmentation, laxity, lentigines and roughness of tretinoin treated subjects were noted by investigators. Subjects receiving tretinoin noted significant improvements in skin wrinkles, tightness, colour and pores. Improvement in overall severity of photodamage was significantly greater for tretinoin treated subjects and was progressive over the study period. Histological findings included a significant increase in mean epidermal thickness. Significant topographical changes were not detected in skin surface replica sets. Cutaneous irritation, the most common side effect, was usually mild and transient. We conclude that tretinoin 0.05% cream significantly improved the appearance of photodamaged

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01790.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01791.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SUMMARYGlucagonoma Syndrome is a rare syndrome comprising hyperglucagonemia, diabetes mellitus, necrolytic migratory erythema and hypoaminoacidemia in the setting of a glucagon producing, alpha cell tumour of the pancreas. We report a case of Glucagonoma Syndrome palliatively treated successfully with octreotide. In addition to classical clinical and biochemical findings, this patient also had a Glomus Jugulars tumour, and Empty Sella Syndrome and demonstrated an unusual pattern of plasma lactate dehydrogenase isoenzymes, features not previously reported in this syndrome.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01792.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SUMMARYA markedly obese 54 year old woman with seropositive rheumatoid arthritis, anaemia, dyspepsia, controlled hypothroidism and depression presented with a seven month history of large pyoderma gangenosum ulcers on the shins. Routine dressings for the ulcers had been ineffective. Her arthritis was being treated with azathioprine and NSAID's. Initial treatment with clobestasol proprionate and disodium cromoglycate under occlusion produced only partial healing. Introduction of Cyclosporin A and continuation of topical therapy, with the addition of triamcinolone acetonide injections, led to progressive healing which was complete after seven months. There has been no relapse to date. Cyclosporine can be combined with azathioprine and local therapy for successful treatment of pyoderma gangrenosum.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01793.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SUMMARYA male infant with the features of Adams‐Oliver syndrome is described. These features included severe aplasia cutis congenita (ACC) of the scalp involving both skin and cranium, a shortened right foot with talipes equinovarus, extensive cutis marmorata telangiectatica congenita and also haemangiomas and ulceration of the abdominal skin. Exposure of the dural membrane was associated with infection, hyponatraemia and finally localised necrosis with herniation of brain and fatal cerebral haemorrhag

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01794.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SUMMARYObjective: To present a case which demonstrates the unusual clinical features of secondary syphilis that may be encountered in tropical Australia.Clinical Features: A syphilitic aetiology was initially missed in a Caucasian female presenting with a rare form of syphilis, “lues maligna”, characterised by nodulo‐ulcerative skin lesions, fever, meningism and a relapsing course.Conclusion: Secondary syphilis is usually manifest in the Northern Territory by a characteristic palmo‐plantar psoriasiform eruption with variable involvement of skin in other body areas. The disease is most commonly seen in the young adult Aboriginal population. However, atypical presentations can occur and vigilance must be maintained for a syphilitic aetiology in unusual skin lesions. The disease may produce significant individual morbidity and may be transmitted non‐venereally to close contacts in the secondary stage. Genital lesions facilitate the transmission of HIV, making early diagnosis and treatment even more

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01795.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Book reviewed in this article:Connective Tissue Diseases Of The Skin. Charles M Lapriere and Thomas Krieg (Editors). Marcell Dekker, Inc, New York. 1993. RRP $150.Itch. Mechanisms and Management of Pruritis. 1st Ed. Jeffrey D. Bernhard. (Ed). McGraw‐Hill Inc. New York. 454 pages. RRP $96 (Australia); $144.95 (New Zealand

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01796.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SUMMARYAlpha Hydroxy Acids are a group of organic acids which have recently become popular in the treatment of several skin conditions.This article explores some of the clinical uses of these products in the treatment ofichthyosis, acne, hyperpigmentation and photo‐damage. Specific recommendations are given for the treatment of each conditio

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01797.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

15th ANNUAL CONFERENCE 5–7th August 19

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01798.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SUMMARYProteolytic enzymes are a family of proteins that serve to degrade necrotic debris derived from cell breakdown. They are produced endogenously often as precursor proteins whose activation is precisely regulated. These activated enzymes serve many functions in normal as well as pathological situations. In particular they are involved in the regulation of cell maturation and multiplication; collagen synthesis and turnover; the development and removal of the perivascular fibrin cuffs found in venous insufficiency and leg ulceration as well as the removal of dead tissues following inflammation. As a limited number of enzymes perform all these functions, it is difficult to predict the effects of applying synthetic proteolytic enzymes to a wound. Many such enzymes are currently commercially available and being promoted as alternatives to surgical wound debridement. It is important for their use to be considered in the context of their interaction with endogenous proteases, their physiological role in tissue, their ability to reach a desired target and the stage of wound healing at the time they are applied.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1994.tb01799.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY