摘要:

SummaryA study of 121 melanoma patients and 139 control subjects was conducted among whites to examine and compare the distribution of non‐dysplastic and dysplastic naevi and other pigmented lesions in each group. Melanoma patients had a mean of 97 melanocytic naevi which were greater than 2 mm in diameter and controls had a mean of 36 such naevi, while the medians were 58 and 22 respectively (p<0.0001). 55% of melanoma patients and 17% of controls had at least one clinically determined dysplastic naevus, and 26% of melanoma patients and 6% of controls had at least 5 dysplastic naevi. Men were found to have more naevi on the trunk than women in both melanoma cases (p=0.01), and controls (p=0.005). Dysplastic naevi were most often found on the trunk and were present at this location in 51% of cases and 77% of controls. Melanoma patients and control subjects with dysplastic naevi, when compared to those without these lesions, had larger number of non‐dysplastic naevi. Lentigines were more common among melanoma patients that among control subjects (p = 0.02). There were no differences in the number of non‐dysplastic naevi among cases with light and dark hair and eyes, or among controls with these characteristics. There also was little variation in the number of naevi according to number of blistering sun

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00399.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryThree cases are presented with a rash due to captopril which, on histology, showed a lichenoid pattern of bandlike upper dermal infiltrate of lymphocytes and histiocytes, together with hydropic degeneration of the basal layer of the epidermis producing Civatte bodies and pigmentary incontinence.The rash presented either as a pityriasis rosea‐like picture which appeared about three to six months after the onset of treatment in patients taking tow doses, or alternatively, as lichenoid plaques which appeared three to six months after commencement of medication in patients taking high doses.Although both clinical patterns produced a “saw tooth” pattern of the epidermal rete ridges, hypergranulosis and acanthosis were seen only with the lichenoid pl

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00400.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryThe case is reported of an 82‐year old woman with a four month history of an erythematous indurated plaque on the left cheek. Light and electron microscopy demonstrated the presence of solar elastosis alone. We believe that this is a new clinical variant of solar elastosis.The spectrum of cutaneous actinic damage is reviewe

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00401.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryA 46 year old man with Crohn's disease developed a widespread pustular eruption associated with intermittent fever and arthritis. Histological examination demonstrated cutaneous vasculitis with leukocytoclasia, and IgM and C3 on direct immunofluorescence. This is characteristic of the bowel‐associated dermatosis‐arthritis syndrome, also known as the bowel bypass syndrome without bypass, a recently described complication of inflammatory bowel disease. This is the ninth case reported to d

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00402.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryA 21 year old man complained of pain and burning sensation on the helices of both ears, precipitated by cold weather. Examination showed tender erythematous nodules. Biopsies of both ears showed the characteristic vascular and inflammatory changes of pernio. In addition, in the left ear, there were foci of necrotic collagen surrounded by palisaded histiocytes. The presence of necrobiosis in pernio has not been reported previously. In this case, necrobiosis would appear to have a vascular basis.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00403.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Book reviewed in this articles:Textbook of Internal Medicine. 1st Edn.Editor‐in‐Chief: William N. Kel

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00404.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryIn a five year period 73 cases of pemphigus vulgaris (PV) and 94 of bullous pemphigoid (BP) were studied to investigate important parameters for these diseases. From the results it was found that the incidence of PV was higher in women whereas that of BP was almost equal in both sexes. The incidence of PV was highest in the sixth decade but was highest in the eighth decade for BP.Indirect immunofluorescence (IIF) was more sensitive in PV whereas direct immunofluorescence (DIF) was more sensitive in BP. The present study provides a basis for comparison with results of previous or future studies in Greek and other populations.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00405.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryPhaeohyphomycosis, an infection characterised by dematiaceous yeast‐like cells, hyphae and pseudohyphae in tissue, is an uncommon condition, often affecting immunosuppressed patients. A sixty four year old boat‐builder, receiving treatment with prednisone and azathioprine developed multiple cutaneous nodules on the extremities. Histology showed a mixed dermal inflammatory infiltrate with scattered spores and hyphae. Culture revealed two organisms, Phialophora richardsiae and Exophiala jeanselmei. Fluorocytosine was initially given but the organism was found to be resistant. Since side effects have been associated with long term ketoconazole therapy, a less toxic and more potent triazole compound, itraconazole, was used. After three months, the lesions had completely resolved without adverse clinical or biochemical chan

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00406.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryLichen nitidus is an unusual dermatosis which tends to involve the trunk, penis and forearms of children and young adults.1It is usually bilaterally symmetrical. We report a case of unilateral palmar lichen nitidus in an elderly man.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00407.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SummaryDrug eruptions are among the most common cutaneous disorders encountered by dermatologists. They occur in many forms and mimic many dermatoses. Fixed Drug Eruption (FDE) has its own characteristics and may be associated with ingestion of a number of agents. The incidence of FDE induced by a specific drug depends on the frequency with which the agent is used in a given part of the world. Recently we have encountered many cases of FDE due to Cotrimoxazole.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1989.tb00408.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY