摘要:

The human fetal thymus has been systematically studied by electron microscopy. The basic structure of the thymic parenchyma is a spongy meshwork, loose in cortex and dense in medulla, composed of two types of epithelial reticulum cell. The meshworks are packed predominantly with thymocytes of variable stages of maturation and partly with macrophages. type, found only in the medulla, is hypertrophic and has characteristic The first type of epithelial reticulum cells is slender and electron opaque, forming supporting element of meshwork(the slender type). The second type, found only in the medulla, is hypertrophic and has characteristic vesicles of two sorts (the hypertrophic type), the large one of which is provided with microvillous projections and contains fine granular substance of moderate electron density which corresponds to the PAS positive granule of METCALF1. SO it might be suggested that the hypertrophic ones have an endocrine activity. The HassaU's corpuscle is composed of cellular aggregation of the hypertrophic type. The function of the thymus in the human fetus is discussed laying stress on the epithelial reticulum cell.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00689.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

Electron microscopical analysis of endothelial linings of the aortic lumen and of the vasa vasorum was made in man, rhesus monkey, dog, rabbit, rat, chicken and pigeon with reference to permeability of the arterial wall, because cholesterol and other substances accumulating in atheromatous lesions have been known to be transported mainly by infiltration into the lesions from the blood stream across the endothelial lining. Porous capillaries were found in vasa vasorum of man, rabbit and pigeon and a well developed vacuole system in the endothelial cells of man and chicken. For the present experiment of atherosclerosis the rabbit has been chosen.In the succeeding experiments we found substances capable of inhibiting the edematous arterial reaction such as pyridinolcarbamate and its derivatives as well as estrogens and glucocorticoids. We have tested these substances for the prevention of atherosclerosis of cholesterol‐fed rabbits and also for the treatment of established atherosclerosis of the animals.The first important finding was the correlation between their inhibiting potency against the edematous arterial reaction and their property of preventing atherosclerosis. The second Important finding was appearance of atrophy, necrosis and calcification of arterial wall along with the atheroma‐preventive effect of estrogen and prednisolone and the absence of such effects in pyridinolcarbamate, while the latter substance enhances the regeneration of smooth muscles in the lesions. Dosages of 10 to 30 mg per kg of pyridinolcarbamate given by mouth daily have shown the atheromatous mass with foam cells, necrosis and degenerative foci being replaced by regenerated smooth‐muscle, collagen and elastic fibers, and the cholesterol content of arterial wall was definitely reduced in the course of 6 to 30 weeks of the treatment, without any untoward effect.Histoenzymatic analysis revealed the increased enzymatic activity of glycolytic enzymes Including glucose‐6‐phosphate dehydrogenase in the arterial wall of animals treated with pyridinolcarbamate and the decreased enzymatic activity of glycolytic enzymes in that of animals treated by estrogen.The results reported in this paper show that the author's edematous arterial reaction has opened a way toward finding antiatherosclerotic agents which may prove to be useful in the prevention and treatment of human atherosclerosis. ACTA PATH. JAP. 19: 15

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00690.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

An autopsy case of bilateral cortical necrosis of the kidneys in a 38‐year‐old unipara is presented. She underwent premature separation of the placenta at the 33rd gestational week which was followed by oliguria and anuria, and terminated in uremia on the 13th hospital day. Spasm of the renal arterial wall was highly suspected as the cause of the bilateral cortical necrosis of the kidneys, and the circumscribed intlmal thickening was thought to be due to the organization of microthrombi which had been produced at the time of the previous attacks of vascular spasm. Participation of predisposition in which the renal arterial tree is susceptible to vascular spasm was suspec

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00691.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

A case of colistln nephrotoxicity without history of previous renal disease was studied by light and electron microscopy of a renal biopsy specimen obtained 11 days after discontinuation of the drug. The histologic picture showed variation from early acute necrosis to regeneration of the damaged renal epithelium. There appeared to be difference of susceptibility among individual tubular epithelial cells to sodium colistinmethanesulfonate in the development of nephrotoxicity. Morphological changes were essentially similar in both the proximal and distal tubules. Indentation of the nuclear membranes was conspicuous and appeared to be demonstrable earlier than the cytoplasmic alterations. ACTA PATH. JAP. 19: 55˜67, 1969

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00692.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

The first case of multiple intrapulmonary artery aneurysms with systemic thrombophlebitis in Japan was reported.This case belongs to the category of the “Hughes‐Stovin syndrome” proposed by Kopp and Green. The clinical and pathological findings of this syndrome was briefly summarized. The main pathological change in the present case was systemic angitis, which appeared to be an underlying cause of the “Hughes‐Stovin

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00693.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

A case of a 6‐year‐old girl with primary osteomyelosclerosis was reported. Clinically she had general fatigue, anemia and hepato‐splenomegaly. The peripheral blood showed anemia with leuco‐erythroblastic picture, anisocytosis and tear‐drop poikilocytosis of the red cells, and marked thrombocytosis. Diagnosis of osteomyelosclerosis was established by biopsies of the liver and bone marrow which showed dry tap aspiration. The patient died 1 year and 2 months after the onset of symptoms.Autospy findings revealed marked flbrillosis, proliferation of all 3 hematopoietic systems and moderate new formation of bone in the bone marrow. Extramedullary hematopoiesis associated with flbrillosis was found in the liver, spleen, lymph nodes, thymus, adrenal glands, lungs and kidneys. There were multiple thrombi in the inferior vena cava, left renal vein, pulmonary vessels, both suprarenal arteries with infarcts in the adrenal glands. It is considered that osteomyelosclerosis is not a reactive or reparative process in nature but a systemic autonomous progressive blood disease. A possible relationship between abnormality of the thymus and primary osteomyelosclerosis was

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00694.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

This report consists of two cases who died after a neurological disorder of the central nervous system consistent with Behcet's disease clinically and pathologically. Post‐mortem examination of the central nervous system revealed mild diffuse meningo‐ encephalitis with multiple foci of softening, demyelination and glial cell accumulation in the pons, midbrain, cerebral peduncle and internal capsule. The significance of these morphological findings has been discussed from an etiological viewpoint of Neuro‐Behcet's syn

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00695.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

A case of a 6‐year‐old girl with unilateral retinoblastoma with widespread dissemination into the subarachnoid space through the optic nerve is reported. The enucleated right eye showed advanced tumor growth characterized by exo‐ and endophytic invasion. The growth infiltrated through the lamina cribrosa and directly into the substance of the optic nerve. Extension into the central nervous system was through the optic nerve. The tumor consisted of only anaplastic cells and showed no tendency of rosette formation. Electron micrographs of the surgical specimen and necropsy material fixed with formalin suggested that tumor cells may be of primitive and anaplastic without any differentiation to glial or neuronal cells. The tumor is consistent with udnifferentiated retinoblastoma previously reported by Reese

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00696.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1969.tb00697.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY