摘要:

Histological criteria of 8 pure and typical endodermal sinus tumor (EST) were compared with the morphological features of 8 human yolk sacs from 5 to 13 weeks of pregnancy. No common features were found with regard to endodermal sinus structure (ESS) and clear‐cell entoblastic pattern (CCEP), but magma reticulare (MR) and eosinophilic hyaline globules (EHG) were detected as common findings. As to the morphology and synthesis of a‐feto‐protein (AFP), some tumor cells with eosinophilic‐granular cytoplasm lining ESS had similarity to the endodermal cell of human yolk sac. Histological features of EST mimicked the morphological structure of endodermal sinus in rodent yolk sac. Pathological study on an ovarian and a gastric adenocarcinoma with high level of AFP concentration demonstrated two cell patterns with eosinophilic‐granular and clear cytoplasm showing analogousness to the endodermal cell of human yolk sac. It was suggested that these tumors showed a selective differentiation to the endodermal cell of human yolk sac and might be called ECT. Further study clarified that ovarian embryonal carcinoma or teratocarcinoma with higher AFP concentration had vitelline component of EST or EC

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02095.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Histiocytic cells with S100 protein compose a cell lineage independent of the monocyte‐macrophage system. Langerhans cells and indeterminate cells in the skin and oral mucosa, interdigitating cells in the T‐zone of the lymph node, and other lymphoid tissues belong to this cell lineage. In addition to these cells, small S100+cells showed morphological transition to large histiocytes. In human fetuses, a large number of S100+lysozyme‐NCA+cells first appeared in the thymic medulla by the end of the third month of gestation, and rapidly disseminated to the various lymphoid organs in accordance with the spread of T‐lymphocytes during the fourth month of gestation. S100+ small cells were more frequent than large cells and showed more rapid dissemination in the early stage. S100‐ lysozyme+NGA+immature macrophages appeared in the liver, spleen, lymph node anlage, and other tissues at the second month of gestation, and their distribution was completely different from S100+histiocytes. Fetal development of T‐zone histiocytes with S100 protein supported the hypothesis that there are two histiocytic cell lines; one is the monocyte‐macrophage system, another is the S100+T‐zone hi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02096.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

This clinicopathologic study concerns 42 cases of synovial sarcoma (13 biphasic and 29 monophasic), including electron‐microscopic examination of five cases, among 753 cases of soft tissue sarcomas. The age of the patients ranged from 9 to 70 years, with a median of 35 years. Tumors occurred most commonly on the extremities with 31 on the lower extremities. Histologically the monophasic type on this occasion included tumors with focal or minimal biphasic differentiation (9 cases) in addition to totally monophasic tumor (20 cases). A comparative light microscopy revealed otherwise inappreciable differences in histologic characteristics between the monophasic synovial sarcoma and certain other spindle cell sarcomas. Ultrastructurally, the cells composing the spindle‐cell area of the synovial sarcoma contained basically the same elements as did the cells forming epithelioid or gland‐like structures, and as the cells in the areas of gradual transitions of the two. One exception was that the cells lining the gland‐like lumina had microvillar projections. Characteristic secretory‐like granules, similar to those seen in the synovial type B cell of the normal human synovium, were evident in all five cases studied electron microscopically. In contrast to the findings of others, patients with monophasic tumors had a better prognosis, 58% surviving 5 years compared to 36% for those with biphas

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02097.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Fibromuscular intimal thickening was seen in the ascending and thoracic aorta of the swine fed 62,500 IU of vitamin D3/kg of diet for three months duration; and after 3 months of vitamin D3withdrawal, atherosclerotic lesions were found. In rabbits, pronounced aortic smooth muscle cell necrosis developed with the forced feeding of 10,000 IU vitamin D3dissolved in corn oil/kg body weight/day for 14 days. Serum analyses indicated that blood calcium did not differ from that of animals fed corn oil alone, but that the level of serum 25‐hydroxy‐ vitamin D3measured by HPLC was 30 times that in the control animals. These data suggest that choleclaciferol (the oxidized sterol with vitamin D3activity) has a very destructive influence on the integrity of arterial wall, and that smooth muscle cell necrosis could be caused by enhanced membrane permeability to Ca2+following 25‐hydroxy‐vitamin D3incorporation into smooth muscle cell me

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02098.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

An ultrastructural study was conducted on a total of 24 tumors selected from 70 tumors Induced by intramuscular injection of Ni3S2in Fischer and Hooded rats. Well differentiated rhabdomyosarcomas were predominantly composed of strap‐like cells containing numerous myofilaments occasionally forming S‐line‐like structures, whereas poorly differentiated rhabdomyosarcomas were made up mainly of round or oval cells with abundant cytoplasm. Embryonal rhabdomyosarcomas contained cells resembling the mast cells in myxomatous areas as well as spindle‐shaped myoblast‐like cells. Mesenchymal tumors exhibited morphological characteristics of the lymphoid cells. The tumor cells from leiomyosarcoma‐like tumors showed myoblast‐like appearance. Tumors diagnosed as fibrosarcoma‐like tumors at the light microscopic level demonstrated the ultrastructural characteristics of fibrosarcomas. The possibility of a multicentric origin of the tumor cells in Ni3S2‐induced tumors h

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02099.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

In order to distinguish endocervical adenocarcinoma from endometrial adenocarcinoma, an immunoperoxidase stain for carcinoembryonic antigen (CEA) was tried. All of 10 endocervical adenocarcinomas revealed CEA and an adenosquamous carcinoma in the uterine cervix also showed it, while a mesonephroid adenocarcinoma in the uterine cervix did not. The immunohistochemical reaction products for the antigen were not observed in the glandular structures of 20 endometrial adenocarcinomas, although CEA was detected in all foci of squamous epithelial metaplasia occurred within 7 endometrial adenocarcinomas. CEA was detected in the endocervical type of glandular epithelium within a special endometrial adenocarcinoma containing predominantly endocervical type glandular epithelium. The immunoperoxidase staining pattern for CEA in the endocervical adenocarcinoma was related to the degree of histological differentiation of tumors, as follows; in the well differentiated glandular structure CEA was located on the luminal surface, while it was detected in the whole cytoplasm of tumor cells within the moderately and poorly differentiated areas. In conclusion, the immunoperoxidase stain for CEA would be useful for estimating malignancy of glandular structures within the uterus, distinguishing endocervical adenocarcinoma from endometrial adenocarcinoma, and grading of histological differentiation of endocervical adenocarcinoma.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02100.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Ninety cases of node‐based non‐Hodgkin's lymphoma in northwestern Kyushu, Japan were classified according to the Japanese Lymphoma Study Group (LSG) and the immunological as well as clinicopathological studies were performed. There were 6 cases of small cell type, 23 of medium‐sized cell type, 25 of large cell type, 20 of pleomorphic type, 10 of lymphoblastic type and 6 cases of specific lymphomatous lesions (Lennert's lymphoma and T‐cell lymphoma with angioimmunoblastic lymphadenopathy‐Iike pattern). Immunologically, the T‐cell character was predominant in pleomorphic type (100%), specific lymphomatous lesions (100%), medium‐sized cell type (80%) and large cell type (60%). Clinically, leukemic manifestation was frequently encountered in all histological types except for large cell type. The leukemic cells in pleomorphic type and T‐medium‐sized cell type were polymorphic, similar to those of adult T‐cell leukemia. Skin lesions were found chiefly in leukemic cases of pleomorphic and T‐medium‐sized cell types, and non‐leuke‐mic cases of T‐large cell type. The worst prognosis was observed in the pleomorphic type, especially of leukemic form. These results support the proposal of pleomorphic type as a distinct entity in prospecting the immunological subtype, clinical manifestations, and survival. In addition, T‐medium‐sized cell and pleomorphic types, having common clinicopathological characteristics, may be categorized as one group. On the other hand, T‐large cell type seems to be composed of heterogenous groups of the peripheral T‐cell tumor, although som

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02101.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Of 180 autopsied cases in children, of which 85 infants were less than one month of age, seven cases of cytomegalovirus infection are described here. Two patients died of congenital cytomegalovirus infection with generalized cytomegalic inclusion disease and one of them was associated with leukemoid mononucleosis. Five cases, 2,8 per cent of 180 cases, were acquired cytomegalovirus infection with localized lesions of cytomegalic cells in the lungs, incidentally found at postmortem examination. The youngest case of acquired cytomegalovirus infection was one month of age. These spontaneous pulmonary infectious changes early in life, associated occasionally with cytomegalic cells in the vascular wall, may suggest that the lung is one of the initial sites of the acquired cytomegalovirus infection preceeding viruria or elevation of antibody titer at later period of life.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02102.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Intaductal papillomas, papillary carcinomas, and normal mammary large ducts were studied by electron microscopy. The intraductal papillomas were divided into two subtypes: fibrous and glandular. Comparative ultrastructural analysis of these two subtypes revealed definitive differences in the nucleus, chromatin, and presence of myoepithelial cells. An irregularly shaped nucleus, aggregated heterochromatin, and prominent myoepithelial cells were the conspicuous features of the fibrous type which appeared to be almost absent in the glandular type. Moreover, the fibrous type possessed intact basal laminae, various differentiations of the cell surface, desmosomes, terminal bar, intrastromal projections of crab‐finger‐like appearance of the myoepithelial cells, and a two cell layer arrangement of epithelial cells. In these features, the ultrastructural appearance of the fibrous type closely resembled that of the cells of the normal mammary large duct. The glandular type, on the other hand, more or less lacked myoepithelial cells, well‐developed organelles and showed a euchromatin pattern in the nucleus. This type resembled the papillary carcinoma in its histological characters. An absence of basal laminae (infiltrating carcinoma only) and the presence of intracytoplasmic lumina were characteristic of papillary carcinomas, and these two features were not found in the intraductal papil

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02103.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A study on the immunopathological similarities between IgA nephropathy and Henoch‐Schoenlein purpura (HSP) nephritis is described. Various examinations were performed as follows. (1) Pathological studies: light microscopic findings and immunofluorescent staining; (2) Measurement of the levels of IgA in pharyngeal washings and sera, and those of IgA quantitated by radial immunodiffusion; (3) Elution studies: renal biopsy specimens obtained from patients with IgA nephropathy and HSP nephritis were treated with citrate buffer (pH 3.2) and the “eluate” was neutralized by sodium hydroxide. The “eluate” was then applied to the acid‐treated sections obtained from the same and other patients with IgA nephropathy as well as sections from patients with HSP nephritis and other glomerular diseases. The sections were stained with FITC‐ conjugated heavy chain specific antihuman IgA antisera and then examined with a fluorescent microscope. There were no differences in pathological findings of IgA nephropathy and HSP nephritis in the light microscopic and immunofluorescent examinations. The levels of IgA in pharyngeal washings and sera were significantly increased in patients with both diseases. IgA antibodies deposited in kidneys from patients with HSP nephritis crossreacted with kidneys from some patients with IgA nephropathy, and vice versa. However, antibodies from patients with IgA nephropathy and HSP nephritis did not react with normal glomeruli or other nephritic glomeruli. It is concluded that there are some immunopathological similarities between IgA nephropathy and

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02104.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY