摘要:

In order to study the interaction between connective tissue and cancer cells, the effect of acid mucopolysaccharides on the subcutaneous growth of Ehrlich ascites tumor was investigated.Chondroitin sulfate was injected subcutaneously into the back of mice, followed immediately by tumor inoculation into the same site. Average tumor weights in chondroitin sulfate‐treated groups were greater than that in control groups, showing statistically significant difference. By means of the same procedure, the effect of chondroitin sulfate and its components on the tumor growth was surveyed quantitatively with various amounts and concentrations, and its activity under the influences of other interstitial components, hydrocortisone and rechallenge was also observed.Results from this experiment indicated that chondroitin sulfate promoted the tumor growth and appear to show that the proliferation of new connective tissue which produces acid mucopolysaccharides is favorable to the growth of cancer cells. Interaction between connective tissue and tumor growth was discussed from a view‐point of intercellular compone

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00107.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Histological and biological observations were carried out on pulmonary tumors in mice which arose in the following four series of experiments: 1) pulmonary tumors in A/Jax and DD strain of mice which developed spontaneously or were induced by a single injection of 3‐methylcholanthrene or 4‐nitroquinoline‐n‐oxide, 2) transplanted pulmonary tumors in the first and second transfer generations, 3) tumorous growth which developed in subcutaneously transplanted lung tissues, and 4) serially transplanted pulmonary tumors in five established lines.The pulmonary tumor in mice was considered as a progressive tumor and the varieties of histology were classified into five or eight types on the basis of relationship between the histological features and the biological activities. The idea of the progression from benign to malignant stage was presented in the pulmonary tumors in mice by the author for the fir

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00108.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Rabbit antiserum against purifled type B particles from spontaneous mouse mammary tumor tissue was conjugated with ferritin for immunoelectron microscopy in order to demonstrate a relationship between type A and B particles. Ferritin granules were found deposited on type B particles and on budding A particles; some were also found similarly deposited on the naked cytoplasmic A particles. These observations suggest that type A particles contain material which is common in antigenic property to that contained in type B particles. The flndings may support the view that the naked cytoplasmic A particles are a precursor of B particles.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00109.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

In this examination of 46 inflamed appendices, the relative proportions of mucosal cells containing IgG, IgM, IgA and light polypeptide chains of kappa and lambda immunoglobulins were determined by immunofluorescent staining and the direct counting of the cells.Immunocytes containing IgA predominated in the stroma of the appendix in all stages of inflammation. IgM‐containing cells were usually scattered and accounted for less than 2% of all fluorescent cells, but were slightly increased in the early stage of inflammation. In the hyperinfective stage of appendicitis, IgG‐containing cells in the mucosa rose to 20% or more. The mucosal columnar epithelium of the appendix was stained by anti‐IgA and anti‐IgM reagents, but no IgG was detected. The distribution and population of cells containing kappa and lambda chains were about 3:2, and showed no significant variation in all the appendices e

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00110.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The proportions of IgG‐, IgA‐, IgM‐ and their k and Λ light polypeptide chain‐containing cells were determined in non‐hypertrophied relatively normal and in recurrently inflamed hypertrophied tonsils by staining with two contrast‐labelled fluorochromes and directly counting such cells in a single tissue section. Their defence mechanisms were also discussed.Human palatine tonsils, like the lamina propria of the gastrointestinal tract, are very rich in plasma cells containing immunoglobulins. In the gastrointestinal tract such cells predominantly contain IgA and those IgA cells were counted above 80% of the population of all immunoglobulin containing cells. In the present study of palatine tonsils, the IgA‐con‐taining cells were fewer than in the lamina propria of the gastrointestinal tract but much more than in the spleen or lymph nodes.Fluorescent immunoglobulin‐containing cells under the submucosa of crypts and superficial portions of lymphoid tissues of non‐hypertrophied tonsils were fewer than 10 per high power field (×400) and relatively rich in IgA. In recurrently inflamed hypertrophied tonsils such immuno‐globulin‐containing cells increased to 20 or more cells per high power field (×400) and migrating IgG‐ and IgA‐ containing cells were present among the non‐reactive epithelial cells. In the areas of severe inflammation with superficial exudate, IgG‐ containing cells predomi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00111.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The fine structures of vascular endothelial surface with linear endothelial folds, were clearly shown by scanning and transmission electron microscopes in large arteries and veins of man and other mammals and the nuclear parts of endothelial cells were shown in the gullies in scanning electron microscopical observation.The effects of substances promoting or inhibiting transendothelial leakage were studied in relation to these structures. Immediately after the challenge their nuclear parts were transiently enlarged and prolonged and the linear endothelial folds became irregular by edematous swelling of endothelial cells and subendothelial structures. Pyridinolcarbamate pretreatment prevented these changes.Administration of cholesterol for 2 weeks induced edematous and spherical change of endothelial cells of aorta; and then localized flat lesions of endothelial cells with flattening of their degenerated nuclear parts in localized areas exposed to mechanical stress from the arterial blood stream. After 3 to 4 weeks the flat lesions changed into elevated lesions, fatty spots or streaks. These endothelial changes were significantly inhibited by pyridinolcarbamate.At the margin of the elevated lesions, nuclear parts of the endothelial cells were exposed on the endothelial fold by elevation of gullies. The exposed nuclear part exhibited a highly deformed and swollen shape and such changes may be followed by an increase in local transendothelial infiltration resulting in expansion of elevated lesions. Chemical inJuries induce weakness of the resistance of endothelial cells and the mechanical stress from the arterial blood stream may aggravate the injury in a special area facing the strong mechanical stress from the blood stream. Summation of such injuries may initiate atherosclerosis in such a special area followed by expansion of atherosclerotic lesion to all directions.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00112.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Renal tumor in Bourneville‐Pringle's tuberous sclerosis complex was examined electron microscopically. It was demonstrated that the cells which have been histologically assumed as smooth muscle origin were not myogenic in ultrastructure but quite similar to that of blastic Schwann cells. It seems to support Inglis's previous view that the tuberous sclerosis complex is essentially the result of dissemination of immature Schwann cells throughout the bod

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00113.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

An autopsy case of non‐specific ulcerative colitis and similar ulceration with so‐called polyps of stomach in a 36‐year‐old female is presented. Her clinical course started with sudden bloody and watery stool which was followed by anemia and hypoproteinemia with gangrenous pyoderma. The patient died 7 months after the onset of symptoms. Autopsy revealed diffuse ulceration with pseudopolyposis from the transverse colon to the rectal region and skip lesions in both the cecum and the ascending colon. Furthermore, a shallow ulcer and so‐called polyps with mucosal bridge were noted along the greater curvature of the stomach. Since histopathological findings and clinical history do not suggest that the ulcer formation of the stomach was caused by the effect of corticosteroid, a possible relationship between ulcerative colitis and gastric ulcer was

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00114.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The clinical history and pathological findings of a 68‐year‐old female with mycosis fungoides were described.Clinically she developed cutaneous eruptions, and plaques to nodules appearlng within the next 4 months. Histopathological examination at biopsy revealed mycosis fungoides. At autopsy, extensive visceral involvement was disclosed (lungs, liver, kidneys, spleen, esophagus, left adrenal gland, lumbar vertebral bone marrow, and lymph nodes). Acute exacerbation of pulmonary tuberculosis was thought to be a terminal ev

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00115.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

A new vital staining method with neutral red has been established where by cerebral ganglion cells can be stainedin vivo.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00116.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY