摘要:

A case of extremely deformed child with acerebellum, meningoencephalocele containing angiomatous mass, renal agenesis, defect of the postoccipital fossa, oesophagus and left part of the diaphragm, and other deformities is presented in this report. The literature hardly contains examples of acerebellum with bilateral renal agenesis.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01198.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

Utilizing trypsin and alkaline degradation methods the separation test of hepatoma islands was performed to evaluate mutual adhesiveness of ratascites hepatomas. The calcium contents of tumor cells were also studied by means of chemical analysis and microincineration method. Calcium contents were estimated in human cancer tissues and invasive omental tumors of ascites hepatomas by the microincineration method. It was found that intercellular adhesiveness was extremely important in determining the histologial architecture of the tumor and that it could be evaluated from their calcium contents. In addition, motility and permeability of tumor cells were studied, as they are possibly factors closely related with calcium contents or intercellular adhesiveness. The interrelationship between histological pattern and invasive growth, metastatic spread and drug susceptibility of tumor was also discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01199.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

In the course of repeated intrabronchial application of 20‐methylcholanthrene to the rabbits, many of them were found to die from uremia with nephrotic syndrome. Approximately 60 % of animals, 3 months or longer under the experiment, showed swollen kidneys with the glomerular tufts deposited with amyloid and tubules dilated with hyaline casts. These lesions in the kidneys as well as in the liver, spleen and adrenals seen in 24 rabbits were consistent with systemic amyloidosis. Autofluorescence similar to that of 20‐methylcholanthrene was observed in the unstained frozen sections of the kidney at the site of amyloid deposition. Amyloidosis developed only in one rabbit of each group which received either intrabronchial application of 4‐nitroquinoline N‐oxide or intravenous administration of 20‐methylcholanthrene. Experimental procedures for inducing amyloidosis and pathogenesis of experimental amyloidosis were

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01200.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

A case of annulo‐aortic ectasia was reported. The patient was a 44 year old Japanese female who expired shortly after the operative intervention against aortic aneurysm and aortic insufficiency. This is the first case of annulo‐aortic ectasia reported in Japan.Histological findings of the resected aneurysm revealed pronounced cystic medial necrosis. At autopsy, similar medial necrosis was found in the remaining aorta, pulmonary artery and some of the major branches of the aorta. The aortic valve cusps also showed myxomatous accumulation of acid mucopolysaccharides and hypoplasia of annular connective tissue. The aortic ring was dilated with evidence of regurgitation.Problems related to pathologic findings were discussed with special reference to a forme fruste manifestation of Marfan's syndrome. We believe cases, such as presented here, should not be considered as a forme fruste of Marfan's syndrome with the present knowledge of the disease, in spite of the morphologic similarity of lesions in our case with those described in classical Marfan's syndr

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01201.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

Five biopsy materials of human amyloidosis and experimental amyloidosis in mice induced by‐, casein injection were studied by an electron microscope, and the following results were obtained. 1. Amyloid consisted of amyloid fibrils with an approximate width of 100 Å. These fibrils were found in both biopsy materials of human cases and experimental amyloidosis in mice. Amyloid was produced by the reticulo‐endothelial cells which were functionally‐disturbed. 3. The process of amyloid production in the reticuro‐endothelial cells was essentially similar to that of collagen synthesis in the fibroblast. The protein synthesized in the granular reticulum was transported to the Golgi complex, and polymerization occurred in the lysosome, and finally complete amyloid fibrils were released from

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01202.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

Two cases of minute epidermoid carcinoma of bronchus were presented; one in situ carcinoma with incipient invasion developing on the basis of long‐standing tuberculous bronchitis and the other in situ carcinoma in association with non‐specific chronic bronchitis. The importance of the role of chronic inflammation in development of epidermoid epithelial metaplasia and epidermoid carcinoma was sugges

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01203.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

Histologic features characteristic for vorious diffuse and localized liver diseases were outlined and the diagnostic criteria for those lesions were described. A case, in which development of early cirrhosis from a stage of acute hepatitis was followed, was briefly described and histologically illustrated. Correlation of clinical and histological diagnosis was tabulated, frequency of diagnostic accordance was calculated and difficulty of diagnosis of chronic hepatitis was emphasized.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01204.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

Clinical and autopsy findings of a rare condition, carcinoma arising in the wall of an idiopathic choledochus cyst, are reported. Endogeneous carcinogen which is likely to be present in the bile, and coexisting chronic inflammation in the wall of the cyst are assumed to be significant causative factors for the development of carcinoma. The possibility of dysontogenetic development of carcinoma was also discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01205.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

A study of the cytological and ultrastructural characteristics, chromosomal value and tumorigenesis of a cultivated golden hamster (Mesocricetus auratus) malignant melanoma was made. Four kinds of cells were observed in the cultures: melanocytes, fusiform cells and two forms of macrophages. Electron microscope observations showed very irregular nuclei with intranuclear lesions, in a type of ring‐like bodies. Vast Golgi zones with melanin formation were seen in the cytoplasm. The melanosomes presented a laminar formation. Extracellular virus‐like particles, 80 mμ in diameter, were observed occasionally. The modal value of chromosome numbers was 44 and they ranged from 42 to 270. When inoculated in hamsters, as small as 500 cells/ml developed tumors in 44–60 days with metastases which retained the property to produce melanin. The significance of the nuclear lesions and virus‐like particles in the golden hamster melanoma cells remain open for di

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1967.tb01206.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY