摘要:

Es ist mir eine hohe Ehre, im Rahmen Ihrer Tagung hier in Tokyo sprechen zu dürfen. Ich danke aufrichtig für alle Freundlichkeit und Förderung, die ich in Japan habe finden dürfen. Ich komme aus Heidelberg; Heidelberg ist die älteste Universität im engeren deutschen Sprachgebiet. Heidelberg und Freiburg sind die beiden Universitäten im Südwesten unserer deutschen Heimat. Die wissenschaftlichen Beziehungen, welche die japanische Pathologie zu Fkeiburg hatte, sind an die Namen Ludwig Aschoffund Franz Büchnergeknüpft. In Heidelberg lehrte zu deren Zeit Prof. Alexander Schmincke. Rie kennen seinen Name von den “Schmincke‐Tumoren”, den lymphoepithelialen Carcinomen Schmincke‐Regaud. Ich bin Schüler von A. Schminckeund verdanke ihm die Bekanntschaft mit dem Problem

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01246.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Cell‐to‐cell interaction was investigated in various malignant tumor cells (human ovarial tumor, lung cancer, carcinoma of larynx and hamster melanoma cell) and in human lymphoblastoid cells (T‐cell (MOLT‐4 cell), thymoma cells and B‐cells (Burkitt lymphoma cell)). Live lymphoblastoid cells did not adhere to the cell surfaces of tumor cells nor the lymphoblastoid cells were ingested by tumor cells wihout immunologic and specific treatment. Tumor cells as well as T‐cells and B‐cells had receptors to concanavalin A on their surfaces, and they showed marked cell binding of tumor cells and lymphoblastoid cells. Moreover, tumor cells that phagocytized lymphoblasts underwent marked cell destruction within 4 hours of cell binding. The cytolytic mechanism of the target tumor cell was probably related to contact with the lymphoblastoid cells and was increased by ingestive activity, and metabolic disturbance by lymphotoxin i

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01247.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Various kinds of epithelial and non‐epithelial tumors, and tumor‐like lesions spontaeously developed in long‐lived mice of strains A/St, C57BL/6 and CBA, and of (C57BL/6 x CBA) F1, hybrids, all of which had been fed in the 2nd Department of Pathology, Gifu University School of Medicine.Some tumors were successfully transplanted into the same strain of mice. An interesting tumor line showing phagocytic activity and growing only in the liver even when inoculated subcutaneously, which was obtained from a reticulum cell neoplasm, Type A by Dunn, originated in the liver of a (C57BL/6 X CBA) F1hybrid male

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01248.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Childhood coronary sclerosis was studied histologically, histochemically immunohistochemically and biochemically on 60 autopsy cases aged from new‐born to 20 years. Intimal thickening often started even in the newborn babies particularly at branching or bending points of the arteries, where fibrocellular proliferation with acid mucopolysaccharide accumulation was the main histological feature. Microthrombi were occasionally demonstrated even in infants, and fatty streaks appeared generally in the second decade. Microthrombi were usually smaller and fewer than fatty streaks. Betalipoprotein and fibrinogen infiltrations into intima were proven in some cases. Mural vascularization was occasionally observed especially in the areas beneath intimal thickening. Pressure effect of the blood stream and anatomically specific points in the arteries seemed to be important as initial factors of coronary sclerosis, where plasma constituents might pass in an easier manner into intimas by increased permeability. Secondarily mural capillaries might play some role in developing atheromas which would produce an eccentrically located luminal obstruction later in adulthood, by local circulatory disturbances within the arterial wall

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01249.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Localization of IgG, IgA and IgM in human palatine tonsils, especially in germinal centers, was studied with the electron microscopical enzyme‐labeled antibody method. The large germinal center cells differentiate into two kinds of cells within the germinal center; one was the medium‐sized germinal center cells not engaging in intracytoplasmic production of immunoglobulins and another was the immature cells producing at least one of the three classes of immunoglobulins, especially IgM. The latter continued to maturate and developed into the intermediate‐matured cells and probably into the plasmocytes. The three classes of immunoglobulins were also deposited in the form of admixtures in the intercellular spaces among the constituent cells of the germinal centers, mainly attaching on the cell membrane of desmo‐dendric cells. In addition, some of the deposits were found freely in the intercellular spaces. Some demureness between the immunoglobulin‐containing cells outside and within the germinal centers were po

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01250.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Postmortem examination of a 26 week old (postmenstrual) human fetus delivered by Cesarean section revealed meconium ileus and many swollen mucus‐secreting cells in the gastro‐intestinal mucosa. The pancreas showed extensive fibrosis, acinar destruction and dilatation of ducts containing eosinophilic casts. Mucous glands of the lungs also revealed mucous cells swollen and distended with their secretary products. The patient is believed to have cystic fibrosis of the pancreas, suggesting that the pathologic manifestations of the disease may begin early in fetal l

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01251.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Pigmented neuroectodermal tumor of infancy originating from the anterior maxilla in a two‐month‐old male has been studied by light and electron microscopy. The tumor is characterized histologically by two types of neoplastic cells embedded in considerable amounts of fibrous stromal tissue. The first type of cell is cuboidal to columnar in shape with an epithelial appearance having abundant cytoplasm; either scanty or a heavy accumulation of melanin pigment is observed in the cytoplasm. These cells are aligned along the cleft‐like space or arranged in small ductal structures. Electron microscopy shows the characteristic features of melanocytic cells having a varying degree of asynchronous maturation of melanosomes. The second type of cells is small and round in shape and has a hyperchromatic nucleus and scanty cytoplasm, resembling neuroblastic cells or lymphocytes. Electron microscopy reveals cytoplasmic processes resembling immature neurits which protrude into the intracellular space; a small number of secretory granules having a central core surrounded by a single limiting membrane are observed in the cytoplasm and cytoplasmic proc

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01252.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An osteolytic bone tumor was found in a 12‐month‐old male NZB mouse. Macroscopically and histologically this tumor was angiosarcoma originating in bone with distant metastasis present in the spleen. The primary tumor was successfully transplanted in the back subcutaneous tissue of syngeneic mice, and the characteristics of the transplants, were found to be similar to those of the primary tumor. The ultrastructure of tumor is descri

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01253.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An autopsy case of systemic histiocytosis with excessive deposition of K‐type light chain crystals was reported in a 58 year‐old man who had consistently showed K‐type light chain paraproteinemia, Bence Jones proteinuria and hypogammaglobulinemia for about 10 years until his death. However, no bony destruction was found by repeated X‐ray examinations. At autopsy, extensive hyperplasia of crystal‐storing histiocytes was observed in the bone marrow, spleen, liver, lymph nodes, interstitial tissues of visceral organs and loose connective tissues. In the bone marrow and some other tissues, mild proliferation of plasmocytoid cells containing small crystals were found, Histochemically the crystals positively stained with various methods for amino acids and proteins, especially with Weigerts’method for fibrin Ultra‐structurally intralysosomal crystal deposition was confirmed in the storage histiocytes and derivation of the crystals from Golgi's sacculi in the plasmocytoid cells was suggested. Biochemically the crystals were regarded as mainly consisting of dimers of a variable half of light chain immunoglobulin and immunochemically and immunohistochemically reacted to anti‐ type light chain serum. Such a generalized storage histiocytosis may be secondarily induced by immunoglobulin synthesized in pla

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01254.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A 7‐year‐old boy, who was diagnosed as typical SSPE by clinical data and laboratory findings, was autopsied and observed by immunofluorescent techniques, light and electron microscope. The morphological characteristics in the brain were perivascular cuffings with plasma cells, lymphocytes and mononuclear cells, gliosis and a large number of intranuclear and intracytoplasmk inclusions in the neuroglias and nerve cells. Various kinds of intranuclear inclusions were elucidated by electron microscopy and the fine structures of these inclusions were described in detail. At least five types of intranuclear inclusions were regarded as specific in SSPE. The presence of intranuclear inclusions of mononuclear cells in the lungs resembling the inclusions in the neuroglias suggested that the disease was not localized in the brain but could be disseminated throughout the b

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb01255.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY