摘要:

The significance of electro kinetic properties of tumor cells can not be accurately assessed without also considering cytogenetic variations between cells and differences In their rates of proliferation. The original assumption that elevated charge densities and increased susceptibility to neuraminidase characterizing tumor cells in general, was confirmed mainly by observations of malignant hepatoma cells in the present study. It was also found that the only property common to both leukemic cells and other malignant cells was an increased susceptibility to neuraminidase. The immunological effects of host animals to the electrophoretic mobility in the transplantable tumor cells were also analysed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01828.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Analysis of approximately 2,000 cases of gastric carcinoma which survived for more than 5 years after gastrectomy revealed that the histopathological classification system proposed by the Japanese Society for Gastric Cancer Research had fair prognostic value and can be recommended for general use.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01829.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The invasive growth of Yoshida sarcoma and Yoshida ascites hepatoma into the rat articular cartilage was examined by light and electron microscopy.The tumor cells were inoculated into the articular spaces of Donryu strain rats and the animals were killed at various intervals ranging from one to seven days.The cells which appeared on the growing fringes of the tumors in the cartilage were mostly tumor cells, yet neutrophils, macrophages, red blood cells, chondrocytes and a closed capillary were also found. In a rare case in which invasion of the cartilage took place from the bone marrow side, osteoclasts could be seen. Phagolysosomes were prominent in the macrophages, while few of them were found in the tumor cells and other cells except for neutrophils. It was suggested that mesenchymal reaction of host induced by tumor cells played an important role in the invasive growth of malignant tumors into the cartilage.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01830.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

C3Hf/Bi mice inoculated intracranially with human adenovirus type 12 were studied by fluorescent antibody technique and light microscopy.The cells with fluorescent T antigens were present in the wall of the ventricles and in the epithelium of the choroid plexuses. Tumors were induced in 21 of 45 mice and the predilection sites were the olfactory bulb, the floor of the fourth ventricle and the tapetum which was in contact with the hippocampus.The relationship between production of the T antigen and tumor development as well as histological features of the tumors was discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01831.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Spontaneous pulmonary tumors (PT3 and PT4) originating in A strain of mice were serially transplanted and their hosts were examined biologically and morphologically.Hyperestrogenism in the hosts was observed by vaginal smear method during some period of serial transplantation, and changes of the visceral organs related to the hyperestrogenism (atrophy of the male sex organs, feminization of the salivary glands and kidneys of males) were observed in the host animals.Morphological findings of the tumors changed from tubular adenocarcinoma to anaplastic carcinoma with increase of transfer generations, and also the survival period of mice was shortened. Hyperestrogenism was observed when the tumors were partially undifferentiated histologically.Extraction of gonadotropin from the tumors was performed with negative result. The mechanism of hyperestrogenism might be a production of estrogen by the tumors.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01832.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

In order to obtain a correlation of adrenal cortex with biochemical function, ultrastructure was closely studied statistically and morphometrically. For the purpose of evoking fluctuations in the function of the adrenal cortex, whole body X‐irradiation (1,000 R), ligation and reopening of the adrenal artery and vein, Metopiron administration, hypophysectomy and ACTH administration were carried out. Whole body X‐irradiation caused hyperfunction of the adrenal. Ligation of adrenal artery and vein caused adrenal hypofunction with a tendency to recovery after release. Metopiron administration and hypophysectomy caused hypofunction of the adrenal cortex. In the mitochondria, ferricyanide reduction by dehydrogenase systems was found in the inner vesicles. The results of morphometrical studies on the correlation of biosynthetic function of the cortlcoids and morphological changes revealed an increase in volume of the crlstae, an increase in number and enlargement of mitochondria, and an increase and dilatation of smooth‐surfaced endoplasmic reticulum at the time of hyperfunction of the adrenal cortex. At the time of hypofunction of the adrenal cortex, the volume increase of mitochondria accompanied by shrinkage of the crlstae were noted. The smooth‐surfaced endoplasmic reticulum showed a tendency to narrowing and d

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01833.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The morphogenesis of massive cerebral hemorrhagic lesions was studied in 6 experimental hypertensive rats. Hemorrhage due to rupture of arteries caused by hypertensive arterial lesions (plasmatic arterionecrosis) was found in the middle cerebral arteries in the subarachnoid space and immediately after their penetrating into the cerebral parenchyma. This primary hemorrhage induced, through circulatory disturbances, secondary bleedings of small vessels and veins, which were all combined to give rise to a massive hemorrhagic lesion. The hypertensive arterial lesions, which were the direct cause of the cerebral hemorrhage, were constituted by necrosis and disappearance of smooth muscle cells and blood plasma infiltration in the media, blood plasma infiltration, especially deposition of fibrin, having periodic cross striation of about 200 Å (fibrinoid degeneration) in the intima, and dissolution and disappearance of the internal elastic lamina

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01834.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Lymph nodes surgically removed from patients with various diseases were histochemically investigated. Enzymes examined were alkaline phosphatase (A1P), acid phosphatase (AcP), β‐glucuronidase (β‐G), and N‐acetyl‐/3‐glucosaminidase (NGa). On the other hand, adult albino rabbits and Wistar rats were immunized by horseradish peroxidase (HrP) mixed with Freund's complete adjuvant and the localizations of these enzymes, antigen HrP and its antibody in their regional lymph nodes at various stages of the immunization were investigated.AIP in the human lymph nodes was mainly localized in the reticulum cells of the paracortical areas in a characteristic network pattern. This pattern was most prominent in the lymph nodes of SLE patients with elevated serum y‐globulin. In the regional lymph nodes of the albino rabbits immunized with HrP, both A1P and anti‐HrP antibody were localized along the processes of reticulum cells in the paracortical areas showing a similar network pattern.Theβ‐Gactivity in the human lymph nodes was very intense and particulated in plasma cells and lymphocytes In the medullary cords and paracortical areas. The proliferation of these β‐G positive plasma cells and lymphocytes in the medullary cords and paracortical areas was most remarkable In SLE patients. In addition, the β‐G activity in these cell types responded most readily and steadily to the antigenic stimulation of HrP to both albino

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01835.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A high incidence of amyloidosis was induced in mice by repeated subcutaneous injection of trypan blue which lead to a disturbance of the reticulo‐ endothelial system.In this series, the mode of amyloid deposition almost coincided with casein‐induced amyloidosis and differed from senile amyloidosis in mice.As a possible mechanism of the occurrence of amyloidosis in this experiment, it was considered that dysfunction of reticulo‐endothelial cells was provoked by trypan blue‐injection and then amyloid was produced in these cells.Our experiment provided an indirect evidence of cellular secretion of amyloid depending on reticulo‐endothel

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01836.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Thirty‐four cases of generalized amyloidosis were studied by the Congo red‐fluorescent method. In the majority of cases (32 cases) amyloid deposition was found more or less in the lung. The initial deposition in the alveolar wall was observed to start along fibrous structures of the alveolar wall, such as basement membrane, and also from smooth muscle of the alveolar wall, of interalveolar septa, and from small nodular mass appearing beneath the endothelium. Amyloid was deposited variably in the alveolar wall, and it was particularly marked in the subpleural and hilar regions, around the fibrosed lesions, especially on the atelectatic side. In a few cases marked or slight deposition was found in medium‐sized and small blood vessels. The pattern of deposition in such cases was, together with their X‐ray findings, designated as the vascular type. In the other type deposition was found in the alveolar wall and partly in the vascular wall and called as the diffuse type. In this type, with the increase of deposition, X‐ray shadows suggestive of pulmonary fibrosis may appear, and with still more marked deposition, symptoms of alveolar capillary block

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01837.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY