ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02906.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

In 1979, a new mechanism of gastric defense named cytoprotection was followed by numerous reports elucidating this interesting and important phenomenon. During this decade, however, the concept and definition of gastric cytoprotection have been modified from the morphological and ultrastructural viewpoints. This review attempts to describe the concept and mechanisms of cytoprotection as well as its pathophysiological features. Specifically,in vitrostudies using isolated cells or monolayer cultured cells as well as molecular investigations of signal transduction system have been documented.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02907.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

In order to clarify the histological and immunohistochemical characteristics of suppurative granuloma in abscess‐forming granulomatous lymphadenitis (AGL), and the relation between AGL and cat scratch disease (CSD), 36 cases of AGL were studied. The combined results showed that there were two types of suppurative granulomas. The suppurative granulomas histologically revealed small lymphocytes of predominantly T cell phenotype distributed among the epithelioid histiocytes bordering central necrotic areas in the suppurative granulomas. These suppurative granulomas could be further subdivided into two groups, mainly those with and without the intermingling of large transformed cells of B‐cell phenotypes: Type B granuloma with large transformed B cells and Type A without large transformed B cells. Both types of granulomas were observed in a varying degree in most cases. According to the predominant type of granulomas, 36 patients with AGL were further classified into two groups: Group I of Type A dominance and Group II of Type B dominance. Warthin‐Starry (WS) silver stain positive bacteria, which are said to be a causative agent of CSD, were present in about 50% of both groups. No Brown‐Hopps' Gram‐positive bacteria, fungus, toxoplasma,ChlamydiaorBacillusCalmette‐Guerin antigen were found in any case. Clinically, there was no significant difference between these two groups. On the other hand, the detection of WS‐positive bacteria seemed to have some relationship with the duration of disease and the history of exposure to cats, and 70% of AGL cases occurred in autumn without a single concur

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02908.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

A silver colloid technique for nucleolar organizer regions (AgNOR) was applied to paraffin sections of maxillary sinus squamous cell carcinomas (MSSCC) of 25 patients. The patients were divided into two groups, one with MSSCC recurring in the primary lesion after treatment with radiotherapy, chemotherapy and for surgery and one without recurrence. Notable differences between the numbers of NOR in neoplastic epithelia and the normal mucosa were observed (P =0.0001), but there were no differences between the numbers of NOR in the recurrent and non‐recurrent carcinomas. This investigation found no prognostic importance in the number of AgNOR in MSSC

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02909.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

The prognostic value of flow cytometry for thyroid papillary carcinoma in aged patients was studied and compared with that of tumor histology. Seventy‐five surgically removed primary papillary thyroid carcinomas larger than 30 mm in diameter were obtained from patients over 60 years of age. A subtotal thyroidectomy with modified radical neck dissection was performed in all patients. Sixteen female patients died of the carcinoma (non‐survivors) and 18 survived longer than 12 years without recurrence (survivors). Histologically, papillary carcinoma was subclassified into poorly and well differentiated types, and the presence of stromal bone formation was noted. Flow cytometry was performed using paraffin‐embedded materials. The incidence of the poorly differentiated type was 2/18 among the tumors of survivors and 6/16 among the tumors of non‐survivors (P =0.08). Stromal bone formation was only found in the tumors of the survivors (6/18 and 0/16;P= 0.014). In flow cytometry, tumors of the survivors showed a DNA diploid pattern (14/14), whereas half of the tumors of non‐survivors (6/12) showed an aneuploid pattern (P = 0.004). Moreover, in the remaining six tumors of the non‐survivors, two showed a third peak at 6C and one showed a higher S fraction. Therefore, only three showed a DNA diploid pattern that was indistinguishable from that of the survivors. These results suggest that flow cytometry is useful for estimating the prognosis of thyroid papillar

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02910.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

The pulmonary vascular alterations of seven patients with idiopathic dilated cardiomyopathy (IDC) were morphometri‐cally examined, and the relation between the vascular alterations and morphological status of the hearts was studied. Most patients with IDC showed not only fibrous thickening of small pulmonary veins but also intimal circumferential fibrosis and medial hypertrophy of small pulmonary muscular arteries to various degrees. The histo‐logical features of the pulmonary vessels were compatible with hypertensive vascular changes observed in patients with mitral stenosis. There was a significant correlation between medial hypertrophy of the pulmonary muscular arteries and right ventricular hypertrophy. The pulmonary vascular changes in IDC were always associated with left atrioventricular dilatation, but were only found in patients with prominent hypertrophy of the left ventricles. Medial hypertrophy of the pulmonary muscular arteries was related more to left ventricular hypertrophy than to left ventricular dilatation. These findings suggest that the pulmonary vascular changes in IDC are caused by venous pulmonary hypertension, which may be developed at the late stage when left ventricular hypertrophy predomina

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02911.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Silver‐binding nucleolar organizer regions (AgNOR) were investigated and compared in 43 cases of gall‐bladder cancers and 10 normal gall‐bladder samples using an image analyzer. The mean numbers of AgNOR per nucleus (AgNOR number) were 3.28 ± 1.38 in the gall‐bladder cancers and 1.86±0.20 in the normal gall‐bladder cases. The respective mean areas of AgNOR per nucleus (AgNOR area) were 6.96±3.78 μm2and 1.89±0.21 μm2. The differences were statistically significant (P<0.0001) for both parameters. In addition, increased frequency and enlargement were both apparently correlated with poor prognosis (P<0.011 andP<0.046, respectively), with AgNOR number and AgNOR area showing tendencies for increase in cases of histologi‐cally high grade malignancy, advanced cancer and regional lymph node involvement.In conclusion, AgNOR number and AgNOR area appear to be useful indicators for the grading of malignancies and for the prediction of gall‐bladd

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02912.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

We studied the morphologic, immunologic and clinical features of 14 cases of primary non‐lymphoblastic non‐Hodgkin's lymphomas of the mediastinum. The patients ranged in age from 3 to 76 years, with a median age of 28 years. According to the Ann Arbor classification, 71 % of our cases were in an early stage. Three cases were in Stage I, eight in Stage II, one in Stage III and two in Stage IV (one with multiple hepatic lesions and another with bone marrow involvement). The patients were heterogeneous in terms of the disease and were therefore histologically classified into three categories: diffuse large B cell lymphoma with sclerosis (DLS;n= 8); large cell anaplastic lymphoma (LC‐Ana; n = 5); and low grade B cell lymphoma of mucosa‐associated lym‐phoid tissue (MALT lymphoma;n= 1). DLS was the most common group and was characterized as CD5, CD10–, CD19+, CD20+, CD21‐ and CD22+. Imprint smears showed azurophilic granules in the cytoplasm of the tumor cells of three of four DLS cases. All of the six cases examined were negative when tested for Epstein‐Bart virus (EBV) sequences after hybridization with the EBV internal repeat probe. DLS and MALT lymphoma cases were of a B‐lineage lymphoma of the thymus, while most of the LC‐Ana cases were of a T‐lineage lymphoma. Patients with non‐lymphoblastic non‐Hodgkis'n lymphomas had a relatively favorable prognosis compared with lymphoblastic lymphoma (P0.05 by t

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02913.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

We report a rare case of cerebellar degeneration that was diagnosed at autopsy in a patient who developed lithium intoxication accompanied by neuroleptic malignant syndrome. This 63 year old female, who suffered from manic depressive psychosis, had received lithium bicarbonate at a daily dose of about 1000 mg for 4 years. She developed a high fever and extrapyramidal symptoms resembling a neuroleptic type of malignant syndrome and died 1 month later. Autopsy revealed an almost complete loss of Purkinje cells with a mild reduction of granule cells in most areas of the cerebellar hemisphere and vermis, except for the tonsil and flocculus, and mild gliosis in the dentate nucleus. In cases of suspected lithium intoxication, one must be alert to the possibility of neuroleptic malignant syndrome and to prevent cerebellar degeneration.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02914.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

An autopsy case of multiple penetrated colonic ulcers with secondary amyloidosis caused by rheumatoid arthritis in a 61 year old woman is reported. Amyloid deposition was conspicuous in the transverse colon with numerous penetrating ulcers that were circumferentially scattered. Deposition was mainly in the small vessel walls of the submucosal layers. In the quantitative comparison of the histological components between the colonic segments affected by severe and mild ulcer formation, occlusive vascular amyloid deposition was revealed more frequently in the severe involved portion than in the mild involved portion. In addition, submucosal fibrosis that tended to appear around ulcers was more extensive and thicker in the former than in the latter. The complete vascular occlusion caused by amyloid deposition was particularly concentrated in the submucosal layer adjacent to the ulcer. These findings indicate that peripheral circulatory disturbance by amyloid deposition in the small vascular walls leads to ulcer formation in the colon.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02915.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY