摘要:

During metamorphosis, the collagen layer (basement lamella) of the resorbing tail fin of bullfrog tadpole was markedly disintegrated, and was invaded by mesenchymal cells from below, which contained cytoplasmic vacuoles enclosing collagen fibrils. Participation of the locally produced collagenase in the process was discussed.By use of the tissue incubation method, collagenolytlc activity was found In the wound tissues of the rabbit dorsal skin, and its significance In the wound healing process was discussed. Some of the repairing tissues after incubation were histologically examined.In the human stomach, high degree of collagenolytlc activity was observed in the mucosa affected by gastritis after Incubation, and there were several evidences that some kinds of cancerous tissues possessed a certain degree of the activity. The collagenolytlc enzyme from the mucosa of gastritis was proved to have the characteristics of animal collagenase, previously obtained from tadpoles or other mammalian tissues.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00805.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

It has been well established that Increase of elastic fibers Is a prominent feature In chronic liver diseases, especially in liver cirrhosis. Little is known, however, about the mechanism of the elastogenesis in liver tissue. As a result of histological examination of the pattern of elastic fiber formation in various kinds of liver diseases, it was concluded that elastogenesis in the liver tissue can be divided into two stages: first stage is proliferation of thin elastic fibers and second step Is remodeling of newly formed and preexistent elastic fibers. It seemed reasonable to conclude that the formation of thin elastic fibers was mainly related to proliferation of arteries and arterioles, from the observation of specimens, which were injected dye from the A. hepatlca. On the other hand, thick elastic fibers found in advanced liver cirrhosis, were supposed as the result of fusion and deformation of preexistent or newly formed thin elastic fibers. Chemical analysis of collagen and elastin of the liver tissues of various conditions showed that the ratio of elastin to collagen increased with the progress of liver fibrosis. These results suggested that elastic fibers in chronic liver diseases were not teleologlcally formed to some pathological condition, but were formed and accumulated as the result of some process.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00806.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

In order to clarify the mechanism of the formation of epithelioid cells (“EG”) some morphological experiments have been done using the rabbits inoculated with several fractions of tubercle bacilli. By fractionation and purification of Mycobacterium tuberculosis H37RV, phosphatide, wax‐A, wax‐B, wax‐C, wax‐D and residual component were obtained. Albino rabbits were inoculated with these tubercle bacillary constituents into the lymph nodes and light and electron microscopic observations of popliteal lymph nodes have been made. EC could be classified into three groups and their subgroups in accordance with the ultrastructural features of the phagocytes and of digestion bodies contained in them. Thus “the pre‐ or non‐typical EG” seemed to be derived chiefly from the preexisting mature phagocytes and “the digestosome type EC” from immature phagocytes. “The phago‐digestosome type EC” had the intermediate characteristics. Among many mycobacterial fractions only phosphatide and wax‐D had the ability to form EC.In comparison with the case of non‐ sensitized animals, emergence of EC was generally more prompt and massive in animals which had been slightly or moderately sensi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00807.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Four of 15 rabbits, injected with hen's egg albumin (EA) intramuscularly once a week for a period in excess of 12 weeks, developed membranous glomerulonephritis (MGN). It was demonstrated that the quantities and qualities of antibodies produced in the MGN rabbits were different than those of non‐membranous glomerulonephritis (non‐MGN) rabbits. MGN rabbits produced small to moderate amounts of total antibodies and precipitating antibodies as measured by antigen‐binding capacity (ABC‐33) of Farr's method and precipitation with radioactive antigen (P‐80), particularly after 12 weeks of immunization. The precipitating efficiencies of the antibodies in their sera declines remarkably and their avidity were lower than those of non‐MGN rabbits late in the course of immunization. MGN rabbits formed relatively small antigen‐antibody complexes after intravenous injection of antigen, which were slowly removed from their circulation. From these results, it was concluded that the properties of antibodies correlated closely with the devel

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00808.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Five cases of von Recklinghausen's neurofibromatosis were examined electron‐microscopically. The tumors were composed of Schwann cells, myelinated and non‐myelinated axons, fibroblasts, collagenous fibers, endothelial cells and mast cells. From our observation, the Schwann cells as well as the fibroblasts were capable of producing collagenous fibers. This observation was strengthened by the following findings: (a) collagenous fibers were just adjacent to Schwann cell surface, occasionally showing a banded structure; (b) the vesicular elements similar to those of the fibroblasts were observed within the cytoplasm of Schwann cells. Each Schwann cell was invariably surrounded by a basement membrane, and in the area of the collagenous fibers formed, the basement membrane became a hazy homogeneous substance extending irregularly into the connective tissue space. The membrane bounded vesicular elements appeared to discharge their content into the extracellular space after fusion with the cell membrane, and here the basement membrane as well as the cell membrane became obscure and looked homogenous. The tumors of von Recklinghausen's neurofibromatosis were basically composed of both Schwann cells and fibroblasts. The name “neurofibroma” seemed suitable for these types of

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00809.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Haematopoietic cells of the rat bone marrow were killed almost completely by using hydroxyurea (OHU), cytoslne arabinoslde (ara‐C),60Co irradiation and busulfan. The relation between the regeneration of haematopoietic cells of the bone marrow and the behavior of the bone marrow lymphocytes and related cells was investigated quantitatively.Bone marrow lymphocytes and related cells were cytologlcally classified Into lymphocytes, transitional cells and blastic cells on the smeared preparation.Comparing the results of the experiment using OHU 2.5 g/kg with those using whole body irradiation of60Co 700R, the absolute number of nucleated cells In the bone marrow was reduced more prominently in the former case than in the latter. Nevertheless, regeneration of haematopoietic cells began earlier In the former case than in the latter.In the experiment using OHU 2.5 g/kg, haematopoietic cells in the bone marrow almost completely disappeared promptly after the treatment. On the contrary, the bone marrow lymphocytes were rather well preserved, making up 59% of control on the 1st day and 54% on the 2nd day. Moreover, it was evident that the decrease in number of bone marrow lymphocytes and the increase in number of transitional and blastic cells occurred simultaneously around the 4th day after the last dosage, just prior to the haematopoietic regeneration.On the 8th day after whole body irradiation with60Co 700R, in parallel with the appearance of haematopoietic regeneration, the bone marrow lymphocytes, transitional cells and blastic cells were the predominant populations In the regenerating bone marrow.In the experiment using ara‐G 600 mg/kg, the number of transitional cells increased evidently prior to haematopoietic regeneration.The author concluded that regeneration of bone marrow haemato‐poiesis can take place earlier and more rapidly, when the bone marrow lymphocytes are provided In sufficient nu

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00810.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

On a consecutive series of 100 cases of gastric carcinoma, htstochemi‐cal investigation of mucous material and 7 kinds of enzymes, including dehydrogenases, phosphatases, and lysosomal enzymes was performed. Mucous membrane of twenty stomachs resected for ulcer served as control. Histologically, thirty of the carcinomas were well‐differentiated, 47 moderately differentiated, and 23 undifferentiated adenocarcinomas. A combination of histochemical reaction of two enzymes, alkaline phosphatase and aminopeptidase was found to be characteristic for the intestinal epithelium, both benign and malignant. Thus, carcinomas consisting of malignant epithelium fulfilling these characteristics could be classified as of intestinal epithelial type, and the others as of non‐intestinal epithelial type. Correlation of tubular structural differentiation of carcinoma and this histochemical differentiation was examined: 14 of 30 (46.7%) morphologically well differentiated, 20 of 47 (42.6%) moderately differentiated, and 10 of 23 (43.5%) undifferentiated adenocarcinomas were classified histochemically in the intestinal epithelial type. There is, apparently, no direct correlation between the enzymatic characteristics and the morphological tubular “differentiation”. It is apparent that the diffuse type of LAUREN16is not “non

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00811.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Primary malignant hemangioendothelioma of the liver of a 21‐year‐old male, was reported. Microscopically the formation of vascular lumen was indistinct.From the findings of silver impregnation stain which showed delicate reticulum fibers intimately encircling the tumor cells, it was suggested that the tumor cells had the nature of the endothelium.A review of the literatures was made on intraabdominal malignant hemangioendotheliomas from 1960 to 1971 in Japan which showed the liver to be the most frequently invol

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00812.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The present case deals with a patient who was suffering concurrently from malignant lymphoma of the nasal cavities and Behcet disease accompanied with colitis ulcerosa.A possibility that Behçet syndrome might be accompanied with malignant tumor is discussed. Moreover, it may be possible to point out the presence of such a type of Behçet syndrome as a “tumoral Behc

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00813.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

An autopsy case of characterltic and severe enteritis with remarkable hypoproteinemla and extensive ulceration having numerous cytomegalic inclusion cells In the mucosal and submucosal capillary endothelia was reported.The pathological findings of this case proved the previous author's opinion that the ulcerative lesions in the digestive tract of the cytomegalic inclusion disease were caused by the cytomegalovirus and the systemic cytomegaloviral infection in the body occurred from the ulcerative lesions.The author advocates that this case be termed as “primary cytomegalic inclusion enteritis”, because this case has no serious basic diseases or pathologically severe extensive lesions in the small intestinal tract, and has received no immunosuppressive treatm

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00814.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY