摘要:

Electron microscopic study was made on precancerous and cancerous lesions in glandular stomach of rats induced by MNNG. Three types of lesions, were found; regenerative glandular hyperplasia, adenomatous hyperplasia and adenocarcinoma. These were compared with the fine structure of similar lesions produced by X‐irradiation in the glandular stomach of mice. The precancerous lesion in the present study demonstrated formation of adenomatous hyperplasia by epithelial cells which included mucoid cells characterized by sparce surface microvilli, a few erratic terminal webs, small number of mucous granules, many small mitochondria, and a bizarre nucleus. The development of these mucoid cells seems to be related with the growth of gastric carcinoma. The ultrastructure of adenocarcinomas revealed many structural variations or abnormalities of cellular differentiation. They were classified into 1) surface and pit mucous cell type, 2) pyloric gland cell type, 3) goblet cell type, 4) paneth cell type, 5) intestinal epithelial cell type, 6) endocrine cell type, 7) oncocyte type, 8) filament‐rich cell type, and 9) anaplastic cell type involving intracellular microcyst cells. Filament‐rich cells were found in poorly differentiated adenocarcinoma or scirrhous carcinoma and may be derived from metaplasia of tumor

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03289.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The relationship between metastatic lesions and the degree of appearance of plasma cells In regional lymph nodes affected by carcinoma of the stomach was observed In this study. At the initial stage of metastasis to a lymph node, numerous plasma cells were found In the lymphatic parenchyma adjacent to the metastatic lesion. As the metastatic lesions Increased, the number of plasma cells decreased. Few plasma cells appeared in the intact lymph node distant from the primary lesion of carcinoma. It Is suspected that this phenomenon may be tentatively explicable from the antigen‐antibody reaction at the Initial stage of metastasis in a lymph nod

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03290.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In the present study, 13 cases of a peculiar gall‐bladder granuloma characterized by marked proliferation of ceroid‐fllled brown histiocytes were pathomorphologically, histochemically and ultrastructurally examined to define the pathologic features of such a lesion previously undescribed in the literature. The lesion grossly showed a granulomatous appearance of yellow brown to dark brown color developing in the wall of gall‐bladder. Histologically, there was proliferation of histiocytes containing abundant brown pigment granules In their cytoplasm. The pigment granules proved to have staining characteristics closely resembling those of lipogenic ceroid‐like pigment. Ultrastructurally, these granules showed membrane‐bound, pleomorphic osmiophilic inclusions of heterogenous materials. With regard to the pathogenesis of this granuloma, it may be suggested that lipid components of bile juice, particularly unsaturated fatty acids and phospholipids, play an Important role as a source of ceroidogenesis In the proliferating hi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03291.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A historical review and the present author's study on diabetic nephropathy have been presented.Three characteristic lesions in KW‐lesion, namely nodular, exudative and doughnut lesion may all be regarded as to be caused by severe circulatory disturbance occurring in intraglomerular branches of the afferent artery. This circulatory disturbance is considered to be brought about by sudden spasm of the peripheral portion of the afferent branches. The diffuse form of Bell may be regarded as to be a slighter type without severe mesangiolysis. Arteriolar hyalinosis and arteriosclerosis and/or atherosclerosis may be caused by intraglomerular circulatory disturbances. The most important problem in diabetic nephropathy, including KW‐lesion and Bell's diffuse form, is to elucidate the mechanism leading to the occurrence of spasm of the peripheral portion of intraglomerular afferent branches. Becker4found fixation of antiactomyosin‐antibody in the mesangial tissue by the immunofluorescent method. Many studies along this line have been made, but none are adequate in fully explaining the mechanism inv

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03292.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A mouse strain, ICR/SLC, was involved In spontaneous amyloidosis with high incidence. The amyloid deposition in this strain was seen mainly in the mucosal propria of duodenum and terminal ileum, liver, spleen, adrenal cortices, and renal glomeruli.The mice, orally administered more than 300 mg/kg of organic germanium for 22 months since 5 weeks old, did not develop amyloidosis. Half of the mice, given 30 mg/kg of organic germanium for 22 months developed amyloidosis. The mice given 5% carboxymethylcellulose, the solvent of organic germanium, were affected with systemic amyloidosis with high frequency. The results showed that the organic germanium successfully inhibited the occurrence of senile amyloidosis with dose response. The agent did not have any apparent relation to the incidence of hepatic cell carcinoma or pulmonary adenoma which is frequently combined with aged mice. Although the actual mechanism involved is not clear, the evidence of the inhibition of senile amyloidosis by organic germanium may give a light to elucidate the pathogenesis of amyloidosis.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03293.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A correlated light microscopical, histochemical and ultrastructural study‐was made on bone lesions repeatedly biopsied from three patients with Hand‐Scbüller‐Christian disease. The histiocytic cells proliferating in the early lesions had a markedly indented nucleus and contained In their cytoplasm varying numbers of Langerhans cell granules and round or irregular‐shaped lipid droplets. Histochemically, the lipid droplets were verified to be lipoprotein rich In fatty acids. Such histiocytic cells differ from highly phagocytic histiocytes or macrophages because of indistinct phagocytotlc activity, and are regarded as a metabolic type of histiocytes. The late lesions were mostly dominated by a xanthogranulomatous tissue chiefly comprised of xanthoma cells and collagen fibers. The xanthoma cells were usually filled with numerous lipid vacuoles which were histochemically proved to mainly contain cholesterol. Almost all the xanthoma cells were closely attached to collagen fibers and often had well‐developed rough endoplasmic reticula. Ultrastructurally, It is suggested that the xanthoma cells are originated from fibroblasts or flbrocytes.As an Important factor to induce proliferation and xanthoma cell transformation of fibroblasts in the late phase, the presence of such a lipoprotein produced in the histiocytic cells of the early phase is

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03294.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An autopsy case of Intracranial malignant teratoma, In an 8 years old female, is presented in this reprot. Clinically, pregnancy test was positive and human chorionic gonadotropins of high titer were found in the urine but precocious puberty was not seen. The tumor was composed of differentiated teratomatous components and embryonal carcinoma with small foci of choriocarcinoma. Embryonal carcinoma seemed to undergo trophoblastic differentiation. These histological findings have been discussed from the viewpoint of its histogenesis and differentiation.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03295.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An autopsy case of abnormal Intracranial vascular networks at the base of the brain corresponding to so‐called rete mirabile, associated with occlusion of bilateral internal carotid arteries was reported. This patient was a 62 year‐old female who died about two months after sudden onset of subarachnoid hemorrhage. At autopsy, abnormal vascular networks termed as rete mirabile were observed to be collateral blood supplies among the cerebral regions with flow of the anterior, middle, and posterior cerebral arteries, caused by long‐stading obstruction of bilateral internal carotid arteries at the syphon level. Morphometrical analysis was done by measuring the length of internal elastic membrane of the internal carotid arteries in cross section, and comparing it with those of controlled persons of the same sex and age without any intracranial disorders and hypertensive histories. The result that no significant difference was observed between the former and the latter values suggested that the unusual cerebro‐vascular disorder of this case developed not on the base of congenital anomaly including hypoplasia of internal carotid arteries or arteriovenous malformation but as an acquired lesion established for a lo

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03296.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An autopsy case of a 19‐year‐old boy who had shown typical gargoyle features, strictly consistent with mucopolysaccharidosis type II (Hunter's syndrome) was reported. Histologically, cytoplasmic vacuolar change was found In hepatocytes, sinusoidal epithelium of spleen, follicular cells of thyroid, Sertoli cells of testis, chromophobe cell of pituitary and generalized fibroblast‐like cells including meninges, cardiac valve and periosteum. The vacuoles consisting of membrane‐bound structures with flocculus protein‐like material and occasional electron dense bodies on electron microscopy, were considered to be the site of mucopolysaccharide deposition by histochemical analysis. Deposition of lipid material consistent with so‐called membranous cytoplasmic body was observed in the neurons of central, peripheral and autonomic nervous system. Hepatosplenomegaly could be explained by cytoplasmic deposition, but the cause of cardiomegaly remained further to be studied. Biochemically hepatic mucopolysaccharide was identified as heparan sulfate, while in the kidney dermatan sulfate and heparan sulfate were detected. The correlation between morphology and biochemistry, and between deposition and degeneration wa

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03297.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb03298.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY