摘要:

Serial renal biopsies were performed to observe in detail the age‐related glomerular IgA deposition in ddY mice. Moreover, lymphocytes from spleens and Peyer's patches (PP) were immunologically examined in the mice at 10 months of age. The incidence of IgA deposition in the glomeruli was 0% at 3 months, 33% at 7 months, 60% at 10 months and 100% at 13 months, but IgA deposits were less intense than IgG and IgM deposits. Serum levels of IgA and polyclonal IgA responses of PP cells were significantly higher in the mice with glomerular IgA deposits. However, neither the Lyt‐l+/Lyt‐2+ cell ratio nor the polyclonal IgA responses of spleen cells were related to IgA deposition. Therefore, gut‐associated lymphoreticular tissue (GALT) probably plays an important role in the pathogenesis of the high IgA response and glomerular IgA deposition observed in this strain. These results suggest that ddY mice would be valuable as a model of spontaneous glomerular IgA deposition, as well as being useful for studying the possible relationship between the mucosal immune system and glomerular IgA deposition. ACTA PATHOL JPN38: 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01067.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The suppressive effect of cyclosporin A (CyA) on the development of antibody‐induced glomerulonephritis was analyzed in rats with serum sickness nephritis. The induction of serum sickness was established by preimmunization and subsequent continuous administration of the same antigen starting 1 month later. When CyA was given in the preimmunization stage, neither induction of glomerulonephritis nor specific antibody response was observed. In contrast, when CyA was administered in the stage of continuous sensitization, mild glomerulonephritis as well as specific antibody response developed. This phenomenon implles that the significant inhibition of the occurrence of immune complex nephritis results from the suppression by CyA of its primary response to the sensitizing antigen. ACTA PATHOL JPN 38: 11–19, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01068.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The correlation between the histology and biologic behavior of phyllodes tumor was studied in order to establish the histologic criteria of this tumor, particularly its malignant counterpart. A preliminary analysis of five tumors with metastases revealed that a single essential indicator of malignant potential was the presence of a disproportionate overgrowth of the stromal elements at the expense of the ductal element. The presence or absence of such stromal overgrowth in the tumor showed a positive correlation with the degree of stromal atypism and the rate of mitoses. Seventeen out of 45 tumors were determined to be malignant, on the basis of our criteria. The arrangement of the stromal component in malignant phyllodes tumors was usually one of the particular sarcomatous types, with or without the focal areas of one of the specified types of sarcoma. On the other hand, 24 tumors recurred locally but never metastasized, and were preferentially interpreted to be benign phyllodes tumor. Histologically, these tumors had a general architecture resembling that of fibroadenoma but were characterized by high cellularity expressed by the distinct formation of bundles or fascicles of stromal tumor cells. The remaining four tumors seemed to form a borderline phyllodes tumor subset. A follow‐up study revealed that, irrespective of the mode of therapy, the outcome of patients with phyllodes tumor was well correlated with the histologic criteria we proposed. ACTA PATHOL JPN 38: 21–33, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01069.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

An immunohistochemical study of keratin, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), vimentin, desmin, myoglobin and S‐100 protein in 15 cases of uterine mixed Müllerian tumor was performed in order to analyze the expression of various antigens in different elements of this tumor. In general, the epithelial and mesenchymal components were separated easily by the presence of keratin/EMA or vimentin, respectively. However, in eight cases vimentin was expressed by epithelial cells and in four cases keratin by solid “sarcomatous” element. EMA was also identified in the “sarcomatous” areas of two cases. Specific differentiation was much easier to identify by immunohistochemical staining than by routine histologic examination. Areas with muscle differentiation were positive for desmin; myoglobin was identified in rhabdomyoblasts. 5–100 protein was present in chondrosarcomatous and liposarcomatous areas. S‐100 protein was also widely distributed in other elements. Quite diverse expression of various antigens revealed by immunohistochemistry reflects the histologic multiplicity

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01070.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Twenty‐eight cases of B cell lymphoma were studied immunohistochemically utilizing a panel of monoclonal antibodies. Of 27 cases tested, 26 were B‐1‐positive and 22 of 24 cases were HLA‐DR positive. There were eight BA‐1‐positive cases, including one follicular lymphoma, and 10 J‐5‐positive cases including five diffuse large cell lymphomas. Some of the J‐5‐positive diffuse large cell lymphomas were considered to be of follicular center cell origin. Infiltration and distribution of non‐neoplastic T cell subsets, BA‐1‐positive B cells, dendritic reticulum cells, Langerhans cells and HNK cells showed close similarity between the structure of follicular lymphomas and that of the reactive follicles. Such similarity to the normal counterpart structure was less apparent in diffuse lymphomas, especially in the large cell type. These findings were interpreted to be an expression of different degrees of neoplastic deviation. There was evidence to suggest that, regardless of the histological classification, a large number of infiltrating non‐neoplastic T cells was related to good prognosis. ACT A

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01071.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Quantitative light microscopical and immunohistochemical analyses, and electron microscopical studies including routine and uranaffin procedures were carried out on specimens of human embryonic and fetal lung to establish the ontogeny and function of neuroendocrine cells (NECs) and neuroepithelial bodies (NEBs). Light microscopically, NEC and NEB were first observed at 8 and 9 weeks of gestation, respectively. The average numbers of both per 100 bronchial trees rapidly increased from the late second trimester. Electron microscopically, a few dispersed dense granules with uranaffln positivity first appeared in immature glycogen‐rich epithelial cells at 7 weeks, and differentiated NECs were observed at 8 weeks. The possibility that these glycogen‐rich epithelial cells might be NEC precursors was therefore proposed. Immunohistochemically, bombesin and serotonin‐immunoreactive (IR) NECs were first demonstrated at 8 and 9 weeks, respectively, and calcitonin‐IR NECs first appeared at 20 weeks. The average numbers of these IR NECs and NEBs increased from the late second to third trimester. Adrenocorticotropic hormone (ACTH)‐IR NECs and NEBs were found only in extrauterine fetal lungs. Bombesin was a cardinal peptide in fetal lungs, and was assumed to play a pulmonary maturation‐promoting or trophic role. ACTA PATHOL JPN 38:

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01072.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

An unusual case of solid hepatic hamartoma, which could not be correctly categorized under the WHO classification, is reported. The well defined, solid nodular lesion, arising in the anterior edge of the left hepatic lobe, was found in a 15‐month‐old female infant. The lesion was composed of irregularly shaped yellow islands of parenchyma and white‐gray nodules of fibrous stroma of various sizes, which were intermingled revealing a mosaic pattern. Prominent bile ductal proliferation was observed histologically in the fibrous stroma, associated in parts with dense or loose periductal bundles and vascular proliferation. The stromal proliferation seemed to result in erosion of the islands of differentiated parenchymal cells with no regeneration. Alpha‐fetoprotein was demonstrated immunohistologically in the parenchymal cells of the lesion. From these findings, the essential component of this solid hamartoma was thought to be markedly proliferating bile ducts associated with periductal fibrosis, resulting in a fibroadenomatous pattern. ACTA PATHOL JPN 38: 75

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01073.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

An unusual nodular transformation of the liver was found in a 53‐year‐old man with meningoencephalitis who died of brain stem herniation. Postmortem examination revealed marked neuronal ischemic changes and bronchopneumonia as well as meningoencephalitis. The liver showed no significant lesions macroscopically. Histologically, there were many small nodules, less than 1 mm in diameter and composed of clear hepatocytes, throughout the liver. The liver cells in these nodules showed mild hyperplastic changes. Many fine granules, stained by orcein and Victoria blue, were found exclusively in the hepatocytes of these nodules. We describe the peculiar histopathology of this case with reference to some related lesions. ACTA PATHOL JPN38: 83–88,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01074.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A massive hepatic infarction was found in a 44‐year‐old man who had suffered from polyarteritis nodosa for two years. The polyarteritis had been well controlled by administration of corticosteroids, but he died due to an opportunistic fungal infection. At autopsy, a massive hepatic infarct and a fresh thrombus occluding the right portal vein trunk were found. In addition, occlusion of the heptic arterial branch with fibrosis and dissociation of elastic fibers due to polyarteritis was noted. Massive hepatic infarction is uncommon. The clinicopathologic features of this case are described, and the pathogenesis of hepatic infarcts is discussed. ACTA PATHOL JPN38: 89–93,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01075.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

An autopsy case of cardiac rhabdomyoma in a male infant is reported. Many nodules of rhabdomyoma were present in all four cardiac chambers and were microscopically composed of ovoid, glycogen‐laden cells and typical “spider cells”. Atrial natriuretic peptide (ANP) was immunohistochemically demonstrated in both normal myocytes and rhabdomyoma cells of both atria, but not in normal myocytes and rhabdomyoma cells of both ventricles. Ultrastructurally, atrial specific granules were present in atrial rhabdomyoma cells and normal atrial cardiocytes, and these showed ANP immunoreactivity with protein A‐gold technique. It could be said that the localization and intracel‐Mar distribution of ANP in this cardiac rhabdomyoma were closely similar to those of normal human heart. With regard to the presence of ANP, cardiac rhabdomyoma cells arising in atria seemed to differ from those in ventricles, although many tumor nodules occurred in both atria and ventricles. Furthermore, it seemed that cardiac rhabdomyomas could also be divided into two parts: 1) an atrial part with ANP, and 2) a ventricular part without ANP. Therefore, this study confirms the hypothesis that cardiac rhabdomyoma is a hamartoma rather than a true neoplasm. ACTA PATHOL JPN38: 95

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1988.tb01076.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY