摘要:

The effectiveness and practicality of low sodium diets are tested in groups of in- and outpatients. The data indicate that roughly one-fourth with severe essential hypertension can respond favorably to prolonged restriction of sodium intake to less than 0.5 Gm. daily. The rice diet is found to be in effect a simple low sodium diet. Under the conditions of outpatient practice, low sodium dietotherapy is usually impractical and must be controlled by frequent analyses of urinary sodium.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Basic hemodynamic studies on experimental coarctation of the aorta just beyond the left subclavian artery have revealed that hitherto unsuspected physical and physiologic factors are involved in creation of hypertension above a coarctation and in changes of pressure pulses below such a lesion. The effects are by no means explained by an increased resistance at the coarctation, as is generally believed. This communication analyzes the roles that changes in capacity and distensibility of the aortic compression chamber and increase in systolic discharge of the left ventricle play in the production of aortic hypertension, and discusses the physiologic compensations in blood flow by which an adequate return to the right heart is maintained despite extreme reduction in flow through the inferior cava. This communication also deals with the ways in which the pressure relations in the lower aorta and femoral artery are altered from the normal, emphasizing the relative shares that damping of the pulse wave and reduced input into the lower aorta play with different degrees of coarctation. The changing characteristics of the murmurs with progressive aortic constriction are also analyzed. The conclusion is reached that all the dynamic changes found in experimental and human coarctation are adequately explained without the assumption of accessory vasoconstriction through reflex or humoral agencies.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

This communication deals with the manner in which collateral arterial channels and a persistent ductus arteriosus affect the dynamics of an uncomplicated aortic coarctation which was studied experimentally by means of artificial shunts and registration of pressure pulses. The conclusion is reached that effective collaterals or a surgical subclavian-aortic shunt can be effective dynamically in reducing hypertension and left ventricular strain and in providing an adequate flow through tissues despite the fact that the femoral pressure pulse does not revert to a normal form. The presence of an aortic-pulmonary shunt affects aortic pressure both through reduction in aortic resistance and augmentation of systolic discharge until very severe degrees of coarctation exist. The right ventricle of the normal heart can function as a systemic ventricle only when the aorta is almost completely occluded.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Studies were carried out in dogs and rabbits subjected to hemorrhagic and tourniquet shock to determine the tissue origins of two newly described vasotropic principles, VEM and VDM. The vasoexcitor principle, VEM, predominates in the blood during the initial compensatory stage and was traced to the kidney. The vasodepressor principle, VDM, prevails during the decompensatory phase and was found to originate in the liver, skeletal muscle and spleen. During the decompensatory phase, there was a progressive deterioration of the hepatic mechanisms for inactivating VDM. Sequential tissue hypoxia during shock is probably responsible for the formation of these vasotropic principles and for the deterioration of the hepatic VDM inactivation system. Special emphasis is placed on the effects of local concentrations of VDM within the liver and on the resultant diversion of blood from the general circulation into the splanchnic viscera.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Of 20 carefully studied patients with angina pectoris given oral visammin, 4 had a significant reduction in number of pains. Eleven stated that their pains were less severe and less easily precipitated while taking visammin. There was questionable improvement in the exercise tolerance test in 2 of 9 patients after oral visammin therapy. The daily oral dose ranged from 40 mg. to 240 mg. Undesirable side effects were encountered in 17 of the 20 patients. Parenteral administration of visammin was evaluated by means of the ballistocardiograph, the exercise tolerance test, and by tilting.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Coronary flow per minute per 100 Gm. of heart with venous drainage into the coronary sinus as measured by the nitrous oxide procedure was compared in the dog with left coronary artery inflow per 100 Gm. of heart perfused by this artery as measured by the rotameter. The error arising from epicardial leak of nitrous oxide was prevented or quantitated by appropriate coverage of the heart. Extremes of the comparisons were +21 and -22 per cent, with an average variation of ±12.4 per cent. The nitrous oxide method is regarded as giving semiquantitative coronary flow values per 100 Gm. of left heart in the dog.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Intracavitary potentials of the human left ventricle were studied in 8 patients by the technic of retrograde ulnar artery or, in one case, pulmonary vein catheterization. The intracavitary potentials from the left ventricle were of the QS variety and confirm Wilson's concept of the earlier depolarization of the intraventricular septum from left to right.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Compression of the neck of the sitting subject caused increase in urinary sodium output without change in glomerular filtration (creatinine clearance) or apparent cardiac output (electrokymograph). The possible existence of an intracranial mechanism sensitive to alterations in volume of extracellular fluid and regulating the volume of extracellular fluid is suggested.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

In this study cockerels were fed varying diets supplemented with lard, vegetable oil, and cholesterol. The degree of atherosclerosis was compared in serial autopsies and only the cholesterol-fed group showed a significant difference. During a period of two years there was no apparent change in the degree of atheroma when the diet was supplemented with cottonseed oil or lard. Reversibility of the cholesterol-induced atheroma was also studied in a few chickens, and it appears that the early lesions may undergo considerable regression after cholesterol feeding is stopped. Older lesions, on the other hand, appear to be quite fixed.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Within a few minutes after its onset, intense pain of acute myocardial infarction was abolished by briefly spraying the precordium with ethyl chloride. Prompt relief of pain did not prevent tissue necrosis, but may have ameliorated the clinical course. We infer that the stimulus for pain in acute infarction is of extremely short duration but gives rise to a secondary, self-sustaining pain cycle which may be terminated by altering the flow of nerve impulses from the skin. The case also illustrates the increased susceptibility to digitalis which develops some days after myocardial infarction.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID