摘要:

Large amounts of dextran were administered to human subjects under standardized metabolic conditions, with the following results: Dextran is a potent osmotic substance which produces marked salt and water retention and rapid plasma volume expansion. About 50 per cent of the amount given is excreted in the urine during the injection period. Nitrogen and phosphorus sparing and an antiketogenic effect are produced during the period of administration. A fraction of the dextran remains circulating for a prolonged period of time and is associated with a sustained depression of venous hematocrit. Metabolism of this fraction cannot be demonstrated, and its ultimate fate in the body is unknown.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

The ultimate fate of the incised commissure following surgery for mitral stenosis will remain unknown for years to come. A clinical appraisal of patients living five years after commissurotomy and a review of available autopsy material from patients surviving surgery for periods up to four years indicates that valvular restenosis does not occur within the first half decade provided the commissurotomy has been properly performed.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

A method of producing experimental cardiac arrest is described, and the characteristics of arrest are reported. The efficacy of epinephrine, norepinephrine, phenylephrine and acetyl strophanthidin is compared in the resuscitation of hearts stopped by this method.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

Newer methods of microscopy promise to provide a better insight into the physicochemical aspects of tissue structure than has been attained by conventional technics. An exploratory investigation is reported of the ultraviolet absorptive behavior of renal arterioles and arteries, employing the Polaroid color-translating ultraviolet microscope. In the arteriolar necrosis accompanying malignant hypertension and renal periarteritis nodosa changes of particular interest were observed.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

Potassium has been rapidly removed from the circulating blood of dogs in 22 experiments in which other extracellular electrolytes were maintained constant. In these experiments potassium extraction occurred in an acute phase accompanied by a reduction in serum level and a second phase of continued extraction with little change in the extracellular concentration. In the first phase the P wave increased markedly in amplitude and width. The A-V conduction time became prolonged. The QRS complex widened, the T wave became broadened and rounded, and the S-T segment depressed, the latter change occurring in the second phase of dialysis. In these experiments, acute depletion of potassium in dogs consistently reflects the electrocardiographic changes ascribed to hypokalemia.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

The significance of the Wilson variety of right bundle-branch block was investigated on the basis of serial electrocardiographic changes seen in almost half of the series. Wilson block may originate from both anteroseptal and posterior infarction; in the former it may form a solitary relic without prognostic significance; in the latter it denotes extensive septal involvement. It may modify the injury pattern of anterior infarction and may abolish the signs of posterior infarction; cardiac infarction may approximate it to the classic form of right bundle-branch block. Except in two patients, less than 4 per cent of the series, it was related to pathologic causes; it should therefore be regarded as a sign of organic heart disease.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

Seven clinical cases with electrocardiographic patterns of constant or variable short P-R interval are reported. The QRS complex was either normal or aberrant. These abnormalities were reproduced experimentally in dogs by the injection of various drugs into the region of the A-V node. The theories advanced to explain these phenomena are discussed. The results indicate that accelerated A-V nodal conduction is responsible for the short P-R interval. The form of the ventricular complex may be dependent upon synchronous or asynchronous activity of the A-V node. A classification of A-V nodal dysfunction is presented.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

The current electrocardiographic criteria for the diagnosis of left ventricular hypertrophy have been analyzed in 100 cases of pure left ventricular hypertrophy proved at autopsy. Only those cases were used in which the greatest thickness of the left ventricle was 13 mm. or more, the right ventricle did not exceed 4 mm. in thickness, and the heart weight exceeded the upper limit of the expected normal. Also, only those cases were studied on whom multiple lead electrocardiograms were available. Conclusions are presented as to which sets of electrocardiographic criteria give the greatest accuracy in the diagnosis of left ventricular hypertrophy.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

The P wave and PsÊ-loop were derived from coplanar outlines of the contour of seven human atria, including left atrial enlargement, in which it was assumed that the process of depolarization spread in a radial fashion from the sinoatrial node. The "derived" planar projections of the P waves of the standard leads and PsÊ-loops were similar in relative amplitude and general contour to those recorded electrocardiographically and vectorcardiographically prior to death.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID

摘要:

In 13 patients with grade III or grade IV hypertensive retinopathy the effect of intramuscular hexamethonium bromide on cerebral circulation and metabolism has been studied. The results have been compared with Dewar's study of hexamethonium in less severe hypertensive patients and with Kety's results following differential spinal sympathetic block. Sixty minutes after intramuscular hexamethonium, mean arterial blood pressure fell 39 per cent, cerebral vascular resistance was reduced 29 per cent, and cerebral blood flow decreased 16 per cent. Cerebral oxygen consumption was maintained at the expense of a reduction in cerebral venous oxygen saturation.

ISSN:0009-7322    

出版商:OVID    

年代:1955

数据来源: OVID