摘要:

The hemodynamic and metabolic effects of a total sympathetic block and of the infusion ofl-epinephrine orl-norepinephrine were studied in 27 euthyroid dogs and in 31 thyroid-fed dogs. The physiologic changes produced by increased concentrations of the thyroid hormones were abolished by preventing the reflex release of epinephrine and norepinephrine with a total sympathetic block. The inotropic, chronotropic and calorigenic effects ofl-epinephrine and ofl-norepinephrine were found to be increased by thyroid feeding. It is concluded that there is a dynamic interrelationship between the thyroid hormones and those of the adrenal medulla and sympathetic nerve endings. The hemodynamic and metabolic changes of thyrotoxicosis are not the result of the isolated activity of the thyroid hormones, but rather are due to the physiologic effects of epinephrine and norepinephrine, as augmented by the thyroid hormones. Studies indicate thatl-norepinephrine is the predominant mediator of the changes produced by thyroid feeding.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

An analysis of the electrocardiograms from 25 patients during reduction of body temperature and total occlusion of circulation reveals marked abnormalities in conduction and rhythmicity. Hypothermia thermia was accompanied by slowing of the heart rate, depression of intracardiac conductivity, and by inhibition of the normal centers of impulse formation with resultant atrial arrhythmias. Circulatory occlusion during hypothermia was associated with a high incidence of ventricular arrhythmias. Changes noted in electric activity of the myocardium tended to return to normal with release of occlusion and warming of the patient.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

A byproduct of experience with the artificial kidney was the detection of reversible electrocardiographic "currents of injury" in patients with electrolyte imbalance. These changes occurred irrespective of anatomic alterations and resembled the changes of acute pericarditis or myocardial infarction. The electrolyte basis for the "current of injury" was established by the prompt abolition of the RS-T segment elevations, when the electrolyte imbalance was corrected by means of artificial hemodialysis.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

This paper presents three cases and the summary of a fourth case, in which occlusion of a renal artery was the cause of hypertension. Three patients were relieved of hypertension by nephrectomy. The literature on nonembolic renal artery occlusion with hypertension is reviewed, including 21 autopsy reports and 16 cases in which the patients were relieved of hypertension by nephrectomy or thromboendarterectomy. When a patient is found to have renal hypertension, the possibility of renal artery occlusion should be considered. Translumbar aortography currently is the best means of demonstrating renal artery occlusion.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

A method is described for recording heart sounds and murmurs on the surface of the heart chambers and great vessels. Studies were performed on normal dogs and in those with murmurs of known origin, chiefly pulmonic and aortic stenosis. In addition, the reappearance of the murmurs in such cases was studied, following the release of caval occlusion. It was found that the systolic murmur of pulmonic stenosis returned almost immediately after release of caval occlusion, whereas the aortic murmurs did not return until usually from six to 10 beats after release. This may provide a basis for the differentiation of right heart and left heart murmurs by a carefully controlled Valsalva maneuver.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

Two cases of aortic septal defect, diagnosed in life by means of cardiac catheterization, are described. An explanation is given of a method, used in these cases, whereby a correct diagnosis could be made before operation. Other methods for diagnosis and differential diagnosis are discussed.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

If given by the intra-arterial route, the immediate effect of the hydrogenated alkaloids of ergot is unpredictable. Vasodilation is obtained in some patients only. However, it was found that in those cases who do not react, the vessels respond more easily to the release of sympathetic tone, proving that, nevertheless, the drug has had an (potential) effect, probably on the neurovascular apparatus. This effect could be demonstrated for many hours and is, therefore, of considerable therapeutic interest. Even with the higher local concentrations possible by the intra-arterial route, the hydrogenated alkaloids of ergot still did not exhibit any adrenolytic action on the peripheral blood vessels in man.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

Cardiac catheterization and angiocardiography studies are reported in two patients with syphilitic aortic aneurysms, both of which compromised the pulmonary circulation. In the first instance the right main pulmonary artery was compressed and pulmonary hypertension proximal to the compression resulted. In the second patient the aneurysm ruptured into the pulmonary artery producing an aortic-pulmonary fistula. This patient also had pulmonary hypertension and evidence at cardiac catheterization of a large left-to-right shunt. The difficulty of making the clinical diagnosis of pulmonary artery compression by an aortic aneurysm is discussed. Cardiac catheterization and angiocardiography were essential for establishing this diagnosis in life.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

The administration of ethinyl estradiol to 100 survivors of myocardial infarction resulted in uniform correction of the abnormal circulating lipid and lipoprotein concentrations. Gynecomastia and depression of libido were well tolerated by the patients but were not ameliorated by an androgen preparation nor by a progesterone analogue. Methyl testosterone, which partly inhibited the estrogen effect, increased the concentration of cholesterol on the beta lipoprotein fraction. Progesterone had no significant effect on the circulating lipids and lipoproteins. Assessment of the effect of ethinyl estradiol on human atherogenesis must depend on long-term evaluation of its influence on morbidity and mortality rates.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID

摘要:

The induction of spinal anesthesia resulted in hypotension and decreased coronary blood flow and myocardial oxygen consumption. At the same time the myocardial extraction coefficient of oxygen was not increased, indicating myocardial oxygenation to be adequate for the lower work load. This does not imply that local ischemia might not occur in the presence of coronary artery sclerosis. The coronary arteriovenous differences of glucose, lactate and pyruvate were not changed during the period of hypotension.

ISSN:0009-7322    

出版商:OVID    

年代:1956

数据来源: OVID