摘要:

An exact test is proposed for the hypothesis stating that the ABO blood group distribution follows the Hardy-Weinberg law. The test is based on the conditional distribution of the observed phenotypic frequencies, given the estimated gene frequencies. For sample sizes of 20 or less, the exact test can be carried out with the aid of a table that lists the significant outcomes.

ISSN:0001-5652    

DOI:10.1159/000153338

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Isoelectric focusing was used to determine the frequencies of Gc subtypes in Icelanders. The gene frequencies observed were Gc1F = 0.107, Gc1S = 0.631 and Gc2 = 0.262. An Icelandic Gc variant allele (Gc Iceland) is shown to have a different isoelectric point from the variant allele Gc-Norway. Gc-Iceland has been detected in 3 unrelated individuals giving the allelic frequency of 0.004 in the Icelandic population. Studies of 65 mother-child pairs confirm the assumed three-allelic mode of inheritance.

ISSN:0001-5652    

DOI:10.1159/000153339

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A sample of 350 families from paternity cases, analyzed for the P blood group system, was studied in order to confirm a previously found tendency to positive assortative mating. No significant deviations from random mating were found. However, when combined with materials from previously published reports, a significant deviation in favour of matings between likes was obtained.

ISSN:0001-5652    

DOI:10.1159/000153340

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Algebraic expressions for the average exclusion frequency and the paternity index are derived for two linked loci, each with two alleles segregating in a population. The effects of recombination and gametic disequilibrium on these two statistics are discussed. As long as recombination is known to exist, the average exclusion frequency is similar for different recombination fractions. The paternity index, on the other hand, depends very much on both the recombination fraction and gametic disequilibrium. The effects of multiple alleles and dominance on these statistics are also briefly discussed.

ISSN:0001-5652    

DOI:10.1159/000153341

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A stable polymorphism of the Pi alleles M1, M2 and M3 close to their observed frequencies has been predicted, simply by relating fitness to the proportion of each genotype having α1-antitrypsin (α1-AT) levels greater than 100 mg/100 ml. By further specifying that the rare S and Z genotypes with low α1-AT levels have enhanced fertility, equilibria of the M, S and Z alleles have also been predicted close to their observed frequencies; however, none of these latter equilibria is stable, mainly because the predicted fitness of the SS genotype is too gre

ISSN:0001-5652    

DOI:10.1159/000153342

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

To see the efficiency of the statistical methods for positive identification of fathers using genetic markers, the statistical properties of the paternity index are studied algebraically and numerically. It is found that the currently used statistical methods are not powerful enough to discriminate between true fathers and non-excluded non-fathers, and, more often than not, may lead to false attributions of paternity. It is, therefore, suggested that exclusion of paternity is the only conclusive evidence that can be accepted by courts of law until better methods are devised.

ISSN:0001-5652    

DOI:10.1159/000153343

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The distribution of C3 and Bf in a Chinese population sample has been investigated. In a total of 388 individuals, 385 SS and 3 FS C3 phenotypes were observed and the following gene frequencies calculated: C3F = 0.0039, C3S = 0.9961. In 200 unrelated individuals, 155 S, 38 FS, 6 F and 1 FS 0.7 Bf phenotypes were found. The gene frequencies calculated from these were BfS = 0.8700, BfF = 0.1275, BfS07 = 0.0025.

ISSN:0001-5652    

DOI:10.1159/000153344

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

1,416 males and 564 female subjects from four Negroid and five Arab tribes and a group of mixed tribes of the Sudan were investigated for the phenotypic distribution of red cell glucose-6-phosphate dehydrogenase by starch gel electrophoresis. In general, the tribes of Negroid origin had higher frequency of GdA compared to the tribes of Arab ancestry. However, the Nilotes showed a lower frequency of GdA allele and the Mahass tribe claiming an Arab origin had a higher frequency of GdA. The immigrant groups from the neighbouring African countries also had a higher frequency of GdA. GdB (Khartoum) was present in low frequencies in both the Arab and Negroid tribes. A great deal of intratribal variation in the phenotypic distribution of G6PD was observed in the Nuba and Gáali tribes from different localitie

ISSN:0001-5652    

DOI:10.1159/000153345

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Blood samples from 156 Jat Sikhs were examined for the ABO, MNS, Rhesus, Duffy and Kell blood groups. Serum and lysate samples were prepared and electrophoretically tested for haptoglobin, esterase D, adenylate kinase, phosphoglucomutase and the acid phosphatase systems. Comparisons were made with other populations of the Indian sub-continent and of contiguous regions.

ISSN:0001-5652    

DOI:10.1159/000153346

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Plasma antigen concentration of plasminogen was approximately 11-13 mg/100 ml in all phenotypes. Specific activities of common PLG 1-1 and second common PLG 2-1 were 16.52 ± 1.43 U/mg (caseinolytic activity/milligram antigen concentration, mean ± SD) and 17.22 ± 2.14 U/mg, respectively. Caseinolytic activity, antigen concentration and specific activity of PLG 1-B were 0.80 ± 0.23 U/ml, 11.39 ± 2.44 mg/100 ml and 6.95 ± 0.96 U/mg. Plasma plasminogen levels of three rare phenotypes (PLG 3-1, PLG 1-C and PLG 1-M) were at least in the normal ranges by immunological and biological

ISSN:0001-5652    

DOI:10.1159/000153347

出版商:S. Karger AG    

年代:1983

数据来源: Karger