摘要:

Identification of the blood group A subtypes, i.e. A1, A2, and A1-A2 intermediate (Aint), by agglutination test, particularly in AB red cells, is ambiguous. The expressions of A subtypes in red blood cells are the consequences of diverse formations of the A substances by the action of three types of blood group N-acetyl-galactosaminyl-transferases controlled by A1, A2, and Aint genes. Therefore, the A subtypes are more directly identified by examining the kinetic characters of A-enzymes existing in plasma. Several Black AB subjects classified as non-A1 by the agglutination test were identified as A1B and AintB on the enzyme basis. A subject serologically classified as A1 had A2-enzyme in her plasma, i.e. she is genetically A2O or A2A2. The present and previous studies indicate that red cell A2 status is occasionally expressed as a result of the combination of Aint and B, and of A1 and superactive B. The imbalance between A1/A2 and A1B/ A2B observed in some Black populations could be attributed to high frequencies of the Aint and B. sup. genes in Blacks.

ISSN:0001-5652    

DOI:10.1159/000153505

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A total of about 4,500 individuals from Northern, Central and Southern Italy have been analyzed for red cell NADH diaphorase. The results show that the Italians differ significantly (p& < 0.005) from the other examined populations of European origin by showing a higher frequency of the Dia2 allele (6.4 ‰) and a lower frequency of other Dia variants (0.6

ISSN:0001-5652    

DOI:10.1159/000153506

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Gc subtypes were studied by isoelectric focusing in schizophrenic patients and controls. No significant differences between patients and controls were found. The results so far on Gc groups and schizophrenia show no consistent pattern and the significant associations reported have not been confirmed.

ISSN:0001-5652    

DOI:10.1159/000153507

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

We have extended our study of an incomplete variant of multiple endocrine neoplasia Type I (MEN IBurin). In this syndrome, primary hyperparathyroidism and prolactin-secreting adenoma are common, with hormone-secreting pancreatic tumors being rarely seen. The recent localization of the prolactin structural gene to chromosome 6 made further investigation of linkage to HLA of particular interest. Results in 2 multigeneration families exclude close linkage to HLA. We cannot at this time draw any inference regarding linkage of MEN IBurin to the prolactin structural gene.

ISSN:0001-5652    

DOI:10.1159/000153508

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The distribution of △-aminolevulinate dehydrase and phosphoglycolate phosphatase phenotypes was analyzed in 500 autochthonous individuals from the Galician population (north-west Spain). The gene frequencies for PGP2 and ALADH2 obtained in Galicia have proved to be the lowest of all the European populations so far examined. Comparisons with other world populations were also mad

ISSN:0001-5652    

DOI:10.1159/000153509

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Haptoglobin (Hp) groups were determined in 65 patients with dementia of Alzheimer type (DAT) and 74 with multi-infarct dementia (MID). The increased Hp1 gene frequency among patients with DAT described by other investigators could not be confirmed in this study. The patients showed no significant difference from the controls with respect to phenotype and gene frequencies, and there were no significant differences between early and late onset cases of DAT.

ISSN:0001-5652    

DOI:10.1159/000153510

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Agarose gel isoelectric focusing was used to investigate the genetic polymorphism of the sixth component of complement (C6) in Japanese. C6 patterns were visualized by the immunofixation procedure. The allele frequencies calculated from 135 individuals were as follows: C6*A = 0.467, C6*B = 0.481, C6*B2 = 0.037, and C6*B3 = 0.015. It is suggested that C6*B3 is the fourth common allele characterizing the Japanese population.

ISSN:0001-5652    

DOI:10.1159/000153511

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

10 rare albumin variants found in Brazil have been compared with 6 others, discovered elsewhere, through horizontal starch gel electrophoresis in four buffer systems. Belém V can be clearly distinguished from Naskapi but shows the same mobility as Máku (= Belém III) in two different pHs. Coari II, Manaus I and Porto Alegre II can be separated from all others in three buffer systems. Belém II (= Mexico) and Belém I also show unique patterns, but Coari I, Porto Alegre I and Belém IV could not be distinguished from Santa Ana. The possibly synonymous Belém III Belém V-Máku should have originated from an Amerindian gene pool, but Coari I-Porto Alegre I-Belém IV-Santa Ana may have a Caucaso

ISSN:0001-5652    

DOI:10.1159/000153512

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A sample of 539 Polish families and 2,500 individuals were analysed to determine whether there was any evidence of linkage between the dermatoglyphic pattern elements on fingertips and blood groups. The results of the present study did not show any indication of linkage between dermatoglyphic patterns on fingertips (ulnar loops, radial loops, whorls and arches) and the ABO, MN, Rh, Kell and Xg blood groups.

ISSN:0001-5652    

DOI:10.1159/000153513

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Data on 72 families with multiple cases of leprosy were analyzed for a susceptibility gene linked to the HLA loci. We conducted segregation analysis with the program POINTER and identity of HLA types by descent analysis to determine the most likely mode of inheritance. We then conducted linkage analysis with the program LINKAS, first assuming linkage equilibrium and then allowing for linkage disequilibrium and etiological heterogeneity. Segregation results suggest a recessive mode of inheritance, especially for the tuberculoid forms of leprosy. The linkage results, limited to tuberculoid forms and assuming a recessive model, suggest a hypothesis of loose linkage with no unlinked locus. When an additive model is assumed, the best fit is obtained with a hypothesis of complete linkage (θ = 0.0) with heterogeneity. We currently favor the additive model as the more plausible one.

ISSN:0001-5652    

DOI:10.1159/000153514

出版商:S. Karger AG    

年代:1985

数据来源: Karger