ISSN:0001-5652    

DOI:10.1159/000153007

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Acid α-glucosidase from the placenta was electrophoretically surveyed in a total of 633 Malaysians, 236 of Malay, 261 of Chinese and 136 of Indian ancestries. A new variant, α-glucosidase 3-1 was observed in 1 Malay and 3 Indians. A polymorphism for this enzyme was observed among Indians, but in Chinese and Malays variants are rare. Phenotype 2-1 was observed once in a Chinese and once in a Mala

ISSN:0001-5652    

DOI:10.1159/000153008

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Four red cell enzyme systems were studied in Malaysian mothers and their newborn belonging to three racial groups, the Malays, Indians and Chinese. No significant heterogeneity was observed in the distribution of phosphoglucomutase (PGM1), adenosine deaminase (ADA), 6-phosphogluconate dehydrogenase (6PGD) and acid phosphatase (AP) phenotypes between mothers and their newborn of the three groups. Pooled mother and child acid phosphatase data show a significant heterogeneity between the Malays and Chinese, and between the Malays and Indians. This is comparable to previous studies conducted. For the placental phosphoglucomutase (PGM3) system, a significant heterogeneity was observed between the Chinese and Malays only. No significant heterogeneity was detected in the distribution of PGM, ADA and 6PGD phenotypes among Malays, Chinese and Indians.

ISSN:0001-5652    

DOI:10.1159/000153009

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The frequency of serum alkaline phosphatase phenotypes and secretor trait is determined for Israeli Jews originating from three distinct geographical regions: Eastern and Central Europe (group I), North Africa (group II) and the Middle East (group III). The frequency of the Pp 2 serum alkaline phospatase phenotype in each of the three groups were 33.56% (group I), 29.79% (group II) and 24.07% (group III). The average frequency for the three groups combined was 30.58%. The corresponding frequencies of the se gene in the three groups were 0.4765, 0.5149 and 0.5468, respectively, and the average frequency for the total number examined was 0.4978.

ISSN:0001-5652    

DOI:10.1159/000153010

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Nepalese blood samples were tested for two plasma proteins and seven red cell enzyme systems. Polymorphic variation was present for the haptoglobin protein system and for the acid phosphatase, phosphoglucomutase locus 1, adenylate kinase and 6-phosphogluconate dehydrogenase loci controlling red cell enzyme systems. Gene frequencies are compared between the eastern and western Nepalese tribes, and with the distribution pattern known in other South and South-East Asian population groups. The possible interpretations of these observations are discussed.

ISSN:0001-5652    

DOI:10.1159/000153011

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The likelihoods of observing 25 four-generational families of schizophrenics comprising 1,333 individuals have been calculated on the basis of 12 different genetic models and one control ‘sporadic’ model. The control model gave a log10 likelihood (L), of –240.92. Five of the genetic models were definitely excluded as incompatible with certain pedigrees. The three models with the highest likelihoods were: one locus, the heterozygote having a 10% probability of being classified schizophrenic (L: –220.05); two interacting loci (L: –219.46); and four polygenes (L:

ISSN:0001-5652    

DOI:10.1159/000153012

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Using a realistic model of meiotic crossing over the variability in full sib genetic identity is estimated by simulating 200 independent pairs of sibs. The standard deviation of the percentage of the autosomal genome identical by descent (IBD) was found to be about 0.056. Simulations of sibships larger than size two revealed that the average within sibship standard deviation is between 0.054 and 0.056, thus indicating that sib pair variability is insensitive to the nonindependence structure present when considering all possible sib pairs contained in a large sibship.

ISSN:0001-5652    

DOI:10.1159/000153013

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

It has not been possible to demonstrate significant sero-genetic differences between lowland and highland Sotho populations; the differences which do exist may well be attributable to random genetic drift. The study shows that the Sotho have received an appreciable genetic contribution from the San they have absorbed but their sero-genetic profile remains eminently Negro. A low frequency of the PTC non-taster allele was found (t = 0.142 ± 0.029) as was the overall frequency for colour blindness (cb = 0.013 ± 0.009

ISSN:0001-5652    

DOI:10.1159/000153014

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In two African communities, inhabitants of a Western Sahara oasis and Bi-Aka Pygmies (Central Africa), a genetic study of the distribution of G6PD phenotypes has been undertaken. Obtained data show the existence in both groups of slow electrophoretic variants with no enzyme deficiency or moderately reduced activity. Biochemical characterization of G6PD types was performed. In the Saharian family in which inheritance pattern of mutant G6PD was investigated, two alleles were found, the Negroid marker GdA- and Gd+Madrona, segregating among the different members. In the Pygmy family the Gd+ Ibadan-Austin gene was detected. The incidence of these mutations in the groups studied, a comparison with similar G6PD variants observed in other African populations and the geographic distribution of these slow molecules are discussed in this paper.

ISSN:0001-5652    

DOI:10.1159/000153015

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The genetic polymorphism of red blood cell glyoxalase I (GLO) has been investigated in 9 population groups in Israel: Ashkenazi Jews, non-Ashkenazi Jews from Iran, Iraq, Balkan, North Africa, Yemen, Turkey and Egypt as well as Arabs living in Israel. The distribution of GLO1 and GLO2 genes in the 9 communities was not homogeneous (x2 = 14.48; d. f. = 8; p < 0.0005). Jews from Iran were found to have the lowest GLO1 frequency (0.2294), while those from Egypt had the highest gene frequency (0.3968). The other investigated communities were shown to have intermediate values for this gene frequency. No significant difference has been found between Ashkenazi and non-Ashkenazi Jews (with the exception of those from Egypt) or Arabs living in Israel.

ISSN:0001-5652    

DOI:10.1159/000153016

出版商:S. Karger AG    

年代:1979

数据来源: Karger