| 1. |
Generation of MHC Class II Diversity by Intra‐ and Intergenic Recombination |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 5-12
LEIF ANDERSSON,
SOFIA MIKKO,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00667.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 2. |
Evolution of Mhc Class II Polymorphism: The Rise and Fall of Class II Gene Function in Primates |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 13-31
Tomas Bergström,
Ulf Gyllensten,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00668.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 3. |
Evolution of Major Histocompatibility Complex Polymorphisms and T‐Cell Receptor Diversity in Primates |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 33-62
RONALD E. BONTROP,
NEL OTTING,
BAS L. SLIERENDREGT,
JERRY S. LANCHBURY,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00669.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 4. |
A “Minimal Essential Mhc” and an “Unrecognized Mhc”: Two Extremes in Selection for Polymorphism |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 63-88
JIM KAUFMAN,
HEINER VÖLK,
HANS‐JOACHIM WALLNY,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00670.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 5. |
Class IIB MhcMotifs in an Evolutionary Perspective |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 89-111
JAN KLEIN,
COLM O'HUIGIN,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00671.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 6. |
Evolution of MHC Class II Allelic Diversity |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 113-122
Hugh McDevitt,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00672.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 7. |
Quantifying the Degree of Convergence in Primate Mhc‐DRB Genes |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 123-140
Colm O'Huigin,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00673.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 8. |
The Origins of HLA‐A,B,C Polymorphism |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 141-180
Peter Parham,
Erin J. Adams,
Kelly L. Arnett,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00674.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 9. |
Pathogen‐Based Models Favoring MHC Genetic Diversity |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 181-197
Wayne K. Potts,
Patricia R. Slev,
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ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00675.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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| 10. |
ExonicMHC‐DRBPolymorphisms and Intronic Simple Repeat Sequenees:Janus’Faces of DNA Sequence Evolution |
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Immunological Reviews,
Volume 143,
Issue 1,
1995,
Page 199-224
FRANZ‐WERNER SCHWAIGER,
JöRG T. EPPLEN,
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摘要:
SUMMARYThe evolution of highly polymorphic gene loci is following routes that cannot be extrapolated from the existing knowledge of single copy genes. In addition, interpreting the evolution of the most polymorphic loci in vertebrates requires a plethora of data from different taxa. We evaluate here the rules for the evolution of Major Histocompatibility Complex (MHC‐)DRBgenes recently established in humans and other primates on the basis of sequences from several artiodactyl species.MHCgenes encode essential molecules for self/altered‐self/non‐self discrimination in the interaction of the organism with its environment. The necessity to effectively present various different antigens to immunocompetent cells causes positive selection pressure on the variability of these genes in the population. Artiodactyls represent the third mammalian order in which this phenomenon was evidenced independently. A further incentive to investigate also the surroundings of MHC‐DRB loci was the presence of a particular repetitive sequence stretch in the vicinity of the polymorphic exon ‐ in addition to the evolutionarily old alleles, ancient polymorphisms and the mechanisms for their generation and/or maintenance. Besides their utility for indirect gene diagnosis (MHC‐DRB typing), the closely linked stretches of simple repetitive DNA in the neighborhood of the highly polymorphic MHC‐DRB genes are also interesting remains of the evolutionary history. Evolutionary developmenl is different in genetically inert intron‐ic DNA compared to the exonic counterparts, despite their close vicinity. The persistence of these simple repeats over nearly 100 million years in one location preserving the same basic motif structure is startling. Indirect evidence is weighed that biological meaning should be considered for these elements. The combined analysis of the polymorphic DRB genes and the (highly variable but persistent) simple repeat stretches deepen our understanding of the complexities within a unique genomic compartment encoding essential molecules for self/non‐self dif‐ferentiation in the interaction of the organism w
ISSN:0105-2896
DOI:10.1111/j.1600-065X.1995.tb00676.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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