ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Patients with stage II reflex sympathetic dystrophy syndrome (algodystrophy) often describe a sensation of beneficial warmth in the affected limb when receiving acupuncture treatment. In a case control study of 10 patients with unilateral algodystrophy stage II, and 10 healthy sex and age-matched controls, we investigated whether acupuncture has an effect in blood volume flow and correlated this with a clinical assessment. Blood volume flow was measured by duplex sonography before, during, and after acupuncture.During acupuncture, blood volume flow increased significantly (+31.1%,p(one-tailed) = 0.024) in the patients’ effected limbs (by algodystrophy) compared with the patients’ untreated limbs (contralateral). It was also elevated compared with the controls’ treated limbs (+23.9%,p= 0.046). The corresponding data after acupuncture were +29.5%,p= 0.057 and +38.3%p= 0.014. All but one patient reported improved symptoms. However, only subjective improvement in function, not pain, was positively correlated to the increase in blood volume flow.In patients with algodystrophy stage II, a significant increase of blood volume flow was attributed to acupuncture and was correlated to functional improvement.

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Synovium and synovial fluid findings in SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome have not been well characterized, and only a few patients have been described in the Americas. We describe clinical, pathologic, and synovial fluid findings in 12 patients with the SAPHO syndrome: hidradenitis suppurativa (7), acne fulminans or conglobata (3), acneiform folliculitis (1) and palmoplantar pustulosis (1). Routine synovial fluid studies were performed in 6 patients, and light and transmission electron microscopic studies were performed in synovium in 2 patients and in bone in 1.The most common musculoskeletal manifestations included erosive or nonerosive oligoarthritis involving metacarpal phalangeal (MCP) and metatarsal phalangeal (MTP) joints as seen in 9 patients, sclerosis of the sacroiliac joints as seen in 5 patients, and osteitis pubis as seen in 1. Three patients had signs of skeletal hyperostosis. The patients with acne fulminans and acneiform folliculitis had chronic aseptic multifocal osteomyelitis. Synovial fluid was sterile in 7, mildly inflammatory in 5, and highly inflammatory in 2. Electron microscopic studies of synovium in 2 patients and of bone in 1 were not useful to detect microorganisms. Three African-American patients with hidradenitis suppurativa presented with pyoderma gangrenosum, and 2 of them had leukocytoclastic vasculitis, and a life threatening course unresponsive to antibiotics, corticosteroids and immunosuppressive therapy.SAPHO in the Americas is most severe in African-Americans with hidradenitis suppurativa, and it presents with heterogeneous musculoskeletal and cutaneous manifestations including erosive polyarthritis or oligoarthritis with nonspecific mild inflammatory fluid. Leukocytoclastic vasculitis and recalcitrant pyoderma gangrenosum were seen in 2 of our patients with the most severe hidradenitis suppurativa. SAPHO syndrome may present with clinical manifestations similar to those seen with seronegative spondyloarthropathies, but it has distinctive cutaneous, radiographic articular, and bone manifestations. Sites of chronic infection need aggressive antibiotic therapy and may need surgical resection.

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Cervical spondylitis has been reported in 35%–75% of patients with psoriatic arthritis (PsA), and this likely represents the highest frequency of cervical involvement among the spondyloarthropathies. Although 2 patterns of cervical spondylitis have been recognized in PsA, this may reflect a lack of a satisfactory definition of cervical spondylitis in PsA. In a retrospective cross-sectional study, we analyzed the clinical records of 100 consecutive patients recruited at a single university hospital who were diagnosed as having psoriatic spondyloarthropathy on the basis of radiographic sacroiliitis. All patients were involved in a clinicoradiologic study of the cervical column to evaluate the frequency and the predictors of this involvement. Forty-one patients showed radiographic signs of cervical involvement and 24 of them (58.5%) complained of cervical pain and stiffness, whereas 17 (41.5%) had radiologic disease with no symptoms. Arthritis duration (odds ratio, 1.08; 95% confidence interval, 0.99–1.19;p< 0.05) and peripheral erosive disease (odds ratio, 2.5; 95% confidence interval, 1.91–6.92;p< 0.05) were found to be associated with cervical spondylitis development. This study showed a high frequency of cervical spondylitis among patients with psoriatic spondyloarthropathy, confirming previous reports. Although none of our patients developed neurologic sequelae, this report also showed that clinical symptoms of cervical pain and stiffness are not a universal predictor of involvement of the cervical spine, and therefore, patients with PsA with longer disease duration and erosive disease should be screened radiologically to detect those cervical lesions (i.e., atlantoaxial subluxation) with potential catastrophic complications.

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

We report a case of a healthy, young, female soccer player who developed progressive pain in her right hip. A bone cystic lesion was found in the right femoral neck and proximal femur. The lesion was considered a benign bone cyst and the patient was treated with injections of autologous bone marrow and grafting into the femoral neck. However, the cystic lesion did not heal. Subsequently, the patient fell and developed a fracture of the femoral neck that required internal fixation. The bone biopsy showed characteristic histologic features of fibrous dysplasia. A bone scan showed other areas of suspected dysplasia. Pamidronate therapy was given, and a reduction of the increased uptake was seen on bone scans. Fibrous dysplasia must be considered in the differential diagnosis of any cystic bone lesion.

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Musculoskeletal tuberculosis (TB) is a rare manifestation of TB comprising 1%–3% of all cases. We describe a patient who had multiple manifestations of skeletal TB, including spondylitis, dactylitis, and Poncet’s disease. The unusual features include multifocal dactylitis, widespread disease in the absence of any risk factor like HIV infection or immunosuppressive treatment, and absence of pulmonary lesion. Treatment with appropriate drugs, using 4 agents for the first 2 months, led to complete recovery. TB can rarely present in an unusual way but is very important to recognize, as with treatment it still carries a good prognosis.

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

The successful treatment of rheumatoid arthritis often requires the use of immunosuppressive medications. Although these agents have different potential toxicities, they share in common the potential for permitting the development of opportunistic infections. We describe 2 patients with chronic rheumatoid arthritis treated with immunosuppressive agents who developed progressive neutropenia with documented splenomegaly. The differential diagnosis included Felty’s syndrome versus bone marrow suppression from their immunosuppressive medication. Although both patients had the triad of Felty’s syndrome, high titer seropositive rheumatoid arthritis with splenomegaly and neutropenia, the diagnosis of this syndrome relies on excluding other potential causative factors. Further investigation revealed that both patients had disseminated histoplasmosis with bone marrow involvement, which most likely represented reactivation from prior exposure toHistoplasma capsulatum. Opportunistic infections such as disseminated histoplasmosis can mimic other disease processes, including Felty’s syndrome, and are important to consider when there is a change in the clinical status of patients with rheumatic disease who are immunocompromised.

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

We describe the clinical findings, laboratory and ancillary studies, and histopathologic findings of 2 patients with hepatitis C virus infection who developed inflammatory myopathy and interstitial lung disease. A review of pertinent literature revealed several other patients with a similar cluster of clinical manifestations. The inflammatory myopathy in the cases reported here was atypical and distinct from that found in the antisynthetase syndrome because it was characterized by mild or intermittent elevation of creatine phosphokinase, absence of anti-JO1 antibodies, and excellent response to oral corticosteroids. Thus, this report supports the hypothesis that hepatitis C virus infection may cause both inflammatory myopathy and pulmonary fibrosis. We suggest that evaluation for hepatitis C virus infection should be pursued in all patients with inflammatory myopathy and pulmonary fibrosis irrespective of anti-JO1 status. We further suggest that hepatitis C should be considered as another cause of myositis and interstitial lung disease in addition to the antisynthetase syndrome.

ISSN:1076-1608    

出版商:OVID    

年代:2002

数据来源: OVID