摘要:

This study was carried out on two groups of healthy young subjects. One group (n = 8) was given a single oral dose of galactose (0.5 g/kg body weight), and a single measurement of blood galactose was made 40 min later. A second group (n = 16) was given a daily supplement of 0.5 g/kg galactose for 15 days, and blood galactose and galactitol were measured. On the first day of the test period, some subjects seemed to tolerate galactose less well than others: galactitol appeared in their plasmas and could be related to a significantly higher galactosaemia than that of subjects without detectable galactitol in the plasma. However, after 15 days of galactose intake, the less galactose-tolerant subjects appeared to have adapted, as indicated by the significant decrease in the blood galactose and the disappearance of galactitol. No change was found in the galactose-tolerant subjects. No significant difference was found between males and females.

ISSN:0250-6807    

DOI:10.1159/000177563

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

To elucidate the possible role of thyroid hormone in somatomedin-C (SmC)/ insulin-like growth factor I regulation in diabetes mellitus and starvation, plasma SmC, liver SmC, and kidney SmC concentrations were measured in streptozotocin-induced (60 mg/kg) diabetic and starved (for 72 h) rats. Triiodothyronine (T3, 5.0 µg/kg every 24 h) was subcu-taneously injected into diabetic rats for 7 days and into starved rats at 12, 36, and 60 h after starvation. Plasma T3, plasma SmC, liver SmC, and kidney SmC concentrations were significantly decreased in diabetic and starved rats. T3 administration restored plasma T3 levels to the normal value in diabetic and starved rats. Plasma SmC and kidney SmC concentrations were significantly increased in T3-treated starved rats, while they were not increased in T3-treated diabetic rats. These results suggest that thyroid hormone may have some role in SmC regulation during starvation, but may have no role in diabetes mellitus in the rat

ISSN:0250-6807    

DOI:10.1159/000177564

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Clofibrate treatment was found to increase by a factor of two the activity of malonyl-CoA-dependent palmitic acid chain elongation in crude ‘microsomal’ fractions isolated from rat small intestine. A slight stimulation was indicated also after feeding a high fat diet containing partially hydrogenated fish oil (PHFO). This effect was, however, not statistically significant. Subcellular localization of this chain elongation activity was studied by Nycodenz gradient centrifugation. Chain elongation of palmitic acid was observed only in fractions containing high esterase activity, suggesting a microsomal localization. Similar distributions were seen after feeding the peroxisomal proliferators clofibrate and PHFO. Chain-shortening activity was found in the fractions containing high catalase activity, confirming our earlier studies suggesting a peroxisomal localization of this activity also in rat small intest

ISSN:0250-6807    

DOI:10.1159/000177565

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The effect of moderate and severe undernutrition on the immune response to EDIM rotavirus was studied in mice. A moderate state of undernutrition was produced by feeding weanling mice either 15 or 30% less diet than the control group had eaten on the previous day, for 7 weeks. After 6 weeks, mice were given 30 µl/mouse of EDIM rotavirus orally and the antibody production was measured 1 week later. The delayed-type hypersensitivity (DTH) response to picryl chloride (PC) was measured as an index of cell-mediated immunity. For severe undernutrition, weanling mice were fed either 30 or 50% less diet than the control group had eaten on the previous day, for 12 weeks. After 11 weeks of feeding, animals were given 30 µl/mouse of EDIM rotavirus either orally or intramuscularly and the antibody production was measured 1 week later. In moderate undernutrition, the serum antibody levels specific to rotavirus and the DTH response to PC were normal in all dietary groups compared with the control group. In severe undernutrition, the antibody levels following oral challenge of rotavirus were similar in all dietary groups. There was a significant impairment of serum antibody levels following intramuscular challenge in the group fed 50% less than the control group. It is concluded (1) that a balanced reduction in food intake does not impair the immune response, unless severe restriction is maintained for a long period of time, and (2) that the antibody response varies with the route of immunizatio

ISSN:0250-6807    

DOI:10.1159/000177566

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Haematological response and ascorbic acid (AA) status were evaluated in 32 young adult females (age 20–34 years) 8 weeks after supplementation with two levels of AA (50 and 100 mg). Both levels of AA intake produced a similar response marked by significant elevation (p < 0.01) in Hb concentration, Hct level, RBC count, serum and leucocyte ascorbate concentrations. Ten weeks after withdrawal of the supplements, values for all parameters evaluated decreased significantly (p < 0.01) to presupplementation levels. Haemoglobin concentration and leucocyte ascorbate remained relatively higher (p < 0.01) than initial values in subjects who received lOOmg AA. This study showed that AA supplementation improved erythropoietic activity and AA status of our female population. However, the higher dose of AA (100 mg) sustained Hb concentration and tissue ascorbate longer after withdrawal of supplementatio

ISSN:0250-6807    

DOI:10.1159/000177567

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The effect of sampling site and closeness of malignant tumor on the retinoid, carotenoid, tocopherol, and tocotrienol concentration of adipose tissue of human breast was studied in 10 cases of breast cancer. The four anatomic quadrants of breast did not differ from each other statistically significantly in relation to adipose tissue concentrations of the vitamins studied. Proximity of malignant tumor did not affect the vitamin concentrations when compared to the more distant sampling sites. Representative sample of breast adipose tissue for vitamin concentration analysis can be obtained from tissue adjacent to the tumor.

ISSN:0250-6807    

DOI:10.1159/000177568

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Five preruminant calves, fitted with chronically indwelling catethers in the hepatic and portal veins and hepatic artery, were fed two kinds of diet (a conventional clotting milk diet and an incurdled milk diet) or fasted for 24 h. The statistical analysis of the plasma growth hormone (GH; nmol/l) or IGFl (nmol/l) daily secretory profiles indicated that hormonal levels were very high in fed calves (GH mean values: 0.40 ± 0.11 and 0.36 ± 0.10, respectively; IGFl mean values: 6.65 ± 0.57 and 7.54 ± 0.33, respectively). The GH secretory profile observed over a 24-hour period showed 7 secretory spikes without periodicity in both diets. In fasting animals, plasma GH and IGFl concentrations were very low (0.17 ± 0.08 and 3.08 ± 0.36, respectively) and stable, they increased with refeeding (1.51 ± 0.05 and 7.36 ± 0.55, respectively). Hepatic IGFl production (µg/kg body weight/day) was 195 ± 7 in standard milk fed calves and -255 ± 30 in others. Our results demonstrated that nutritional factors, such as different kinetics of gastric emptying or fasting, may influence hepatic IGFl production in the conscious ne

ISSN:0250-6807    

DOI:10.1159/000177569

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000177570

出版商:S. Karger AG    

年代:1990

数据来源: Karger