1. |
PREFACE |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 5-5
Arne Geisler,
René Klysner,
Arne Mørk,
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02492.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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2. |
CONTRIBUTORS |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 7-10
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PDF (128KB)
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02493.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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3. |
INTRODUCTION |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 11-14
MOGENS SCHOU,
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02494.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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4. |
A COMPARISON OF LITHIUM EFFECTS ON HUMAN BRAIN AND RAT BRAIN NORADRENALINE‐SENSITIVE ADENYLATE CYCLASE |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 15-20
Ehud Klein,
R.H. Belmaker,
Michael Newman,
Jan Gruszkiewicz,
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摘要:
Abstract:Lithium (Li) is a drug with numerous biochemical effects. Many of these biochemical effects occur only at high Li concentrations, or disappear after chronic Li treatment. Such effects are probably not related to Li's mechanism of therapeutic action. Inhibition of noradrenaline (NE)‐sensitive adenylate cyclase has been proposed as a possible therapeutic mechanism of action for Li. Tolerance does not develop to this effect, which has been reported to occur reliably beginning at 2mM Li in rat cortex. Since 2mM Li is at the upper limit of therapeutic levels in humans, controversy has continued as to whether Li inhibition of NE‐sensitive adenylate cyclase is a mechanism of Li's therapeutic action or a mechanism of Li toxicity. We hypothesized that human brain NE‐sensitive adenylate cyclase may be more sensitive to Li inhibition than rat brain NE‐sensitive adenylate cyclase. Fresh cortical human grey matter was obtained from the edges of surgically removed brain tumors in seven patients. Results showed significant inhibition of NE‐sensitive adenylate cyclase at 1mM Li. These results support the possibility that inhibition of NE‐sensitive adenylate cyclase is a mechanism of Li's therape
ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02495.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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5. |
ALTERATIONS IN MONOAMINE‐CONTAINING NEURONAL FUNCTION DUE TO ADMINISTRATION OF ANTIDEPRESSANTS REPEATEDLY TO RATS. |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 21-34
Alan Frazer,
Irwin Lucki,
Matthew Sills,
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02496.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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6. |
COMPARISON OF THE INFLUENCE OF VARIOUS ANTIDEPRESSANT TREATMENTS ON BETA‐ADRENERGIC RECEPTORS |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 35-42
R. Klysner,
A. Geisler,
P.H. Andersen,
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PDF (360KB)
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02497.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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7. |
EFFECTS OF LITHIUM AND ANTIDEPRESSANTS ON ELECTROPHYSIOLOGICAL AND BIOCHEMICAL PROCESSES IN THE CNS. |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 43-54
Joachim E. Schultz,
Christoph Kopanski,
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02498.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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8. |
ALPHA‐ADRENERGIC RECEPTOR CHANGES DURING ANTIDEPRESSANT TREATMENT |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 55-65
J. Vetulani,
L. Antkiewicz‐Michaluk,
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02499.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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9. |
BETA ADRENERGIC RECEPTOR FUNCTION IN DEPRESSION AND THE EFFECT OF ANTIDEPRESSANT DRUGS |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 66-79
Ghanshyam N. Pandey,
Puppala Sudershan,
John M. Davis,
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摘要:
Abstract:It has been suggested that alterations of monoamine receptor sensitivity in the central nervous system may be associated with some forms of affective illness. It has been observed by several investigators that chronic treatment with antidepressant drugs causes down regulation of NE receptor coupled adenylate cyclase and beta adrenergic receptor binding in rat brain. This observation has led to the suggestion that the therapeutic effects of antidepressant drugs may be related to the changes in the responsivity of beta adrenergic receptors. In order to examine if depressive illness may be associated with altered beta adrenergic function, we studied adenylate cyclase and its responsiveness to norepinephrine and isoproterenol in the leukocytes obtained from patients with psychiatric illness and normal controls as an index of beta adrenergic receptor function. We also studied the effects of antidepressant drugs, in vitro, on isoproterenol sensitive leukocyte adenylate cyclase. We observed that norepinephrine and isoproterenol sensitive leukocyte adenylate cyclase in depressed patients are significantly decreased as compared to normal controls. Our results appear to have been replicated by another group of investigators. We also observed that certain antidepressnt drugs potentiate isoproterenol stimulated accumulation of cyclic AMP in human leukocytes. This potentiation was most pronounced in the case of iprindole. These results thus indicated a decreased beta adrenergic receptor function in patients with depressive illness. Whether or not such decreased receptor function is associated with depressive illness or is a manifestation of some other changes unrelated to the illness is not clear. Our results also indicate that some antidepressant drugs may enhance adrenergic transmission by potentiating the effects of neurotransmitters on beta adrenergic receptors.
ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02500.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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10. |
INFLUENCE OF LITHIUM IN VITRO AND IN VIVO ON THE CATECHOLAMINE‐SENSITIVE CEREBRAL ADENYLATE CYCLASE SYSTEMS |
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Acta Pharmacologica et Toxicologica,
Volume 56,
Issue S1,
1985,
Page 80-97
A. Geisler,
R. Klysner,
P.H. Andersen,
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PDF (697KB)
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ISSN:0001-6683
DOI:10.1111/j.1600-0773.1985.tb02501.x
出版商:Blackwell Publishing Ltd
年代:1985
数据来源: WILEY
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