摘要:

&NA;This bibliography is compiled from over 250 journals (listed after the bibliography in this issue). Each issue ofAIDShereafter will list papers relevant to AIDS and HIV entered into the database over a one‐month period. A cumulative bibliography covering 12 months is published in the first issue (January) each year.This issue contains papers entered into the database between 1 November 1987 and 31 October 1988.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

摘要:

&NA;Placental isoferritins (PLF), known to be immunosuppressive in Hodgkin's disease and other states, were found to be increased in sera of subjects infected with HIV. We assayed for PLF using a ‘sandwich’ antigen capture enzyme‐linked immunosorbent assay (ELISA) employing two monoclonal antibodies. Individuals with lymphadenopathy, with or without symptoms suggestive of AIDS‐related complex, had the highest serum levels, which declined with progressive immunodeficiency. Total (normal) ferritins, in contrast, increased progressively with stage of disease. PLF was found on a subset of CD8 lymphocytes and appeared to block detection of the CD8 antigen by specific monoclonal antibodies. Elution of PLF by incubation with levamisole, but not by culture medium alone, led to the unblocking of the CD8 determinant on these cells. Profiles of isoferritins in HIV infection may provide clues to prognosis. PLF, a physiologic down‐regulator of hematopoiesis and cellular immunity, could play a role in the progressive immune deficiency, marrow suppression and HIV expression that lead to AIDS.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

摘要:

&NA;A 23‐amino‐acid‐long peptide (AIEKYLEDQAQLNAWGCAFRQVC) representing the transmembranous protein gp32 in SIVmacwas used in site‐directed enzyme‐linked immunosorbent assay (ELISA) for detection of HIV‐2‐specific antibodies in 567 sera from Bissau, Guinea Bissau. Ninety out of the 567 sera were identified to contain HIV‐2 antibodies by whole antigen ELISA and Western blot assays. The peptide ELISA correctly identified 89 out of these 90 seropositives (sensitivity 98.9%). Three sera falsely interpreted to be positive were encountered (specificity 99.4%). The HIV‐2 peptide was also used for testing of 93 HIV‐1‐positive Swedish sera. None of these sera reacted. Site‐directed serology employing synthetic peptides should be considered for application as a screening assay.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

摘要:

&NA;This study evaluates two AIDS risk‐reduction interventions targeted at homosexual and bisexual men. Participants were randomized into two peer‐led interventions: both involved a lecture on ‘safer sex’, and one provided a skills‐training component during which men could discuss and rehearse the negotiation of safer sexual encounters. Follow‐up data collection assessed self‐reported changes in sexual behavior at 6 and 12 months. Skills training increased condom use for insertive anal intercourse. In sessions providing skills training, condom use increased, on average, by 44% between pre‐test and second follow‐up compared with only 11% on average in sessions which did not provide such training.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

摘要:

&NA;Recombinant human interferon beta (rIFN‐&bgr;) reduces replication of HIV in cultured peripheral mononuclear cells. The effect is most pronounced when high levels of the drug are employed. Maintenance of the rIFN‐&bgr; in culture is required since removal of the agent generally leads to a return of virus production by the infected cells. Moreover, at low concentrations of the drug, a breakthrough in HIV replication is observed. High concentrations of the rIFN‐&bgr; (> 100 units/ml) were cytotoxic for transformed T cells. This latter observations suggests that rIFN‐&bgr; might be useful in human T‐cell malignancies. Beta interferon therefore might be useful for the treatment of HIV infection, particularly since side effects of the drug are limited in treated individuals.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

摘要:

&NA;In this study the effect of interferon (IFN) on uninfected cells (H9 −) and cells infected (H9 +) with HIV‐1 was investigated. In both H9 − and H9 +, IFN was unable to inhibit Sindbis virus replication. HIV‐1 replication was inhibited by a maximum of 22% at 1000 U/ml of IFN. In both H9 − and H9+ cells IFN exhibited a limited antiproliferative effect. There was activation of the 2′‐5′oligo‐A‐synthetase (E enzyme) and the protein kinase enzyme systems, but low activation of the ribonuclease F was seen in both H9− and H9+ cells. From these results it can be concluded that IFN produces a limited antiviral and antiproliferative effect in both H9− and H9+ cells, and a defective ribonuclease F pathway might be responsible for this limited activity.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

摘要:

&NA;Total immunoglobulin (Ig) and IgG subclass levels were measured in 72 patients with AIDS or AIDS‐related complex (ARC). IgG2subclass levels were found to be significantly decreased in the AIDS/ARC patients with pyogenic infections compared with both similar individuals without bacterial disease and the HIV‐negative control group.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

摘要:

&NA;A patient with HIV infection presented with multiple cutaneous Kaposi's sarcomata. Biopsy of one of these showed the presence of amastigotes within an otherwise typical Kaposi's sarcoma. Further investigations proved the patient to have visceral leishmaniasis (kala azar). Visceral leishmaniasis has been reported in HIV infection but it is rare and this presentation is unique. The patient made a good response to a prolonged course of treatment with sodium stibogluconate and allopurinol.

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID

ISSN:0269-9370    

出版商:OVID    

年代:1989

数据来源: OVID